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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Peptidyl-glutamate 4-carboxylase.
Alternative Name(s)
Gamma-glutamyl carboxylase.
Vitamin K-dependent carboxylase.
Reaction catalysed
[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O <=> [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol
  • The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron.
  • The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K.
  • It catalyzes the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system.
  • 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein.
  • The 4-pro-S hydrogen of the glutamate residue is removed and there is an inversion of stereochemistry at this position.
PRIAM enzyme-specific profiles4.1.1.90
KEGG Ligand Database for Enzyme Nomenclature4.1.1.90
IUBMB Enzyme Nomenclature4.1.1.90
MEDLINEFind literature relating to

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-