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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 220.127.116.11
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|Vitamin K-dependent carboxylase.|
|[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O <=> [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol|
- The enzyme can use various vitamin-K derivatives, including
menaquinol, but does not contain iron.
- The mechanism appears to involve the generation of a strong base by
oxygenation of vitamin K.
- It catalyzes the post-translational carboxylation of glutamate
residues of several proteins of the blood-clotting system.
- 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in
a specific domain of the target protein.
- The 4-pro-S hydrogen of the glutamate residue is removed and there is
an inversion of stereochemistry at this position.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-