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ENZYME

ENZYME entry: EC 4.1.1.90

PURL: https://purl.expasy.org/enzyme/EC/4.1.1.90
Accepted Name
peptidyl-glutamate 4-carboxylase
Alternative Name(s)
gamma-glutamyl carboxylase
vitamin K-dependent carboxylase
Reaction catalysed
4-carboxy-L-glutamyl-[protein] + 2,3-epoxyphylloquinone + H2O + H(+) = phylloquinol + L-glutamyl-[protein] + CO2 + O2
Comment(s)
  • The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron.
  • The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K.
  • It catalyzes the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system.
  • 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein.
  • The 4-pro-S hydrogen of the glutamate residue is removed and there is an inversion of stereochemistry at this position.
Cross-references
BRENDA4.1.1.90
EC2PDB4.1.1.90
ExplorEnz4.1.1.90
KEGG Ligand Database for Enzyme Nomenclature4.1.1.90
IUBMB Enzyme Nomenclature4.1.1.90
MEDLINEFind literature relating to 4.1.1.90
MetaCyc4.1.1.90
Rhea expert-curated reactions4.1.1.90
UniProtKB/Swiss-Prot
Q07175, VKGC_BOVINQ9MYY3, VKGC_DELLEP38435, VKGC_HUMAN
Q9QYC7, VKGC_MOUSEQ5RF50, VKGC_PONABO88496, VKGC_RAT
Q9GL59, VKGC_SHEEP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-