ENZYME entry: EC 1.2.1.72

Accepted Name

erythrose-4-phosphate dehydrogenase

Alternative Name(s)

E4P dehydrogenase

E4PDH

erythrose 4-phosphate dehydrogenase

Reaction catalysed

D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH

Comment(s)

Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate.
Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.

Cross-references

BRENDA

1.2.1.72

EC2PDB

1.2.1.72

ExplorEnz

1.2.1.72

PRIAM enzyme-specific profiles

1.2.1.72

KEGG Ligand Database for Enzyme Nomenclature

1.2.1.72

IUBMB Enzyme Nomenclature

1.2.1.72

IntEnz

1.2.1.72

MEDLINE

Find literature relating to 1.2.1.72

MetaCyc

1.2.1.72

Rhea expert-curated reactions

1.2.1.72

UniProtKB/Swiss-Prot

A0KGD2, E4PD_AERHH	A4SRF2, E4PD_AERS4	Q5E7R0, E4PD_ALIF1
B5F9T4, E4PD_ALIFM	B6EMW1, E4PD_ALISL	B4RWC5, E4PD_ALTMD
A8APE1, E4PD_CITK8	Q47XD5, E4PD_COLP3	A7MJQ2, E4PD_CROS8
A7ZR35, E4PD_ECO24	B7UHW9, E4PD_ECO27	B7MMA9, E4PD_ECO45
B7LFI3, E4PD_ECO55	P0A9B8, E4PD_ECO57	B5YQB9, E4PD_ECO5E
B7NHY6, E4PD_ECO7I	B7MZM0, E4PD_ECO81	B7LYU4, E4PD_ECO8A
C5A0J7, E4PD_ECOBW	B1XEL0, E4PD_ECODH	A8A467, E4PD_ECOHS
A1AFB1, E4PD_ECOK1	Q0TDS9, E4PD_ECOL5	P0A9B7, E4PD_ECOL6
B1IT76, E4PD_ECOLC	P0A9B6, E4PD_ECOLI	B7N7H3, E4PD_ECOLU
B6I761, E4PD_ECOSE	B1LDD2, E4PD_ECOSM	Q1R7A6, E4PD_ECOUT
C5BAU7, E4PD_EDWI9	A4WE72, E4PD_ENT38	B2VF24, E4PD_ERWT9
B7LPD5, E4PD_ESCF3	Q5QVL6, E4PD_IDILO	B5XUB7, E4PD_KLEP3
A6TDT2, E4PD_KLEP7	Q6D086, E4PD_PECAS	C6DFH8, E4PD_PECCP
Q7N7Z6, E4PD_PHOLL	Q6LMN0, E4PD_PHOPR	B4EUH7, E4PD_PROMH
Q15QK3, E4PD_PSEA6	Q3ILL8, E4PD_PSET1	A1SVN9, E4PD_PSYIN
B5F5J5, E4PD_SALA4	A9MRF0, E4PD_SALAR	Q57K44, E4PD_SALCH
B5FUI3, E4PD_SALDC	B5QXJ7, E4PD_SALEP	B5RE31, E4PD_SALG2
B4THF4, E4PD_SALHS	B4T5H2, E4PD_SALNS	Q5PJI5, E4PD_SALPA
A9N3Q6, E4PD_SALPB	C0PY46, E4PD_SALPC	B5BFN5, E4PD_SALPK
B4TV39, E4PD_SALSV	Q8XGA4, E4PD_SALTI	Q7CPU5, E4PD_SALTY
A1S9A4, E4PD_SHEAM	B8E5U5, E4PD_SHEB2	Q12QA4, E4PD_SHEDO
Q087Q7, E4PD_SHEFN	B0TUC0, E4PD_SHEHH	A3QAX7, E4PD_SHELP
Q8EIB2, E4PD_SHEON	A8H0M9, E4PD_SHEPA	A4Y3R9, E4PD_SHEPC
B8CU41, E4PD_SHEPW	A0L0K7, E4PD_SHESA	Q0HM63, E4PD_SHESM
Q0HRM3, E4PD_SHESR	A1RN69, E4PD_SHESW	B2U0U3, E4PD_SHIB3
Q31WI6, E4PD_SHIBS	Q32BY7, E4PD_SHIDS	Q0T0X3, E4PD_SHIF8
P0A9B9, E4PD_SHIFL	Q3YXU5, E4PD_SHISS	C4L9J3, E4PD_TOLAT
A7MTQ2, E4PD_VIBC1	A5F9G1, E4PD_VIBC3	P0C6C2, E4PD_VIBCH
Q87LL0, E4PD_VIBPA	Q8DCA1, E4PD_VIBVU	Q7MHL0, E4PD_VIBVY
A1JPR1, E4PD_YERE8	Q1CB62, E4PD_YERPA	Q7CGS4, E4PD_YERPE
Q1CEY2, E4PD_YERPN	Q666Q0, E4PD_YERPS

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