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ENZYME entry: EC 1.2.1.72

Accepted Name
erythrose-4-phosphate dehydrogenase.
Alternative Name(s)
E4P dehydrogenase.
E4PDH.
erythrose 4-phosphate dehydrogenase.
Reaction catalysed
D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH
Comment(s)
  • Was originally thought to be an EC 1.2.1.12, but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate.
  • Forms part of the pyridoxal-5'-phosphate coenzyme biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
Cross-references
BRENDA1.2.1.72
EC2PDB1.2.1.72
ExplorEnz1.2.1.72
PRIAM enzyme-specific profiles1.2.1.72
KEGG Ligand Database for Enzyme Nomenclature1.2.1.72
IUBMB Enzyme Nomenclature1.2.1.72
IntEnz1.2.1.72
MEDLINEFind literature relating to 1.2.1.72
MetaCyc1.2.1.72
Rhea expert-curated reactions1.2.1.72
UniProtKB/Swiss-Prot
A0KGD2, E4PD_AERHH;  A4SRF2, E4PD_AERS4;  Q5E7R0, E4PD_ALIF1;  
B5F9T4, E4PD_ALIFM;  B6EMW1, E4PD_ALISL;  B4RWC5, E4PD_ALTMD;  
A8APE1, E4PD_CITK8;  Q47XD5, E4PD_COLP3;  A7MJQ2, E4PD_CROS8;  
A7ZR35, E4PD_ECO24;  B7UHW9, E4PD_ECO27;  B7MMA9, E4PD_ECO45;  
B7LFI3, E4PD_ECO55;  P0A9B8, E4PD_ECO57;  B5YQB9, E4PD_ECO5E;  
B7NHY6, E4PD_ECO7I;  B7MZM0, E4PD_ECO81;  B7LYU4, E4PD_ECO8A;  
C5A0J7, E4PD_ECOBW;  B1XEL0, E4PD_ECODH;  A8A467, E4PD_ECOHS;  
A1AFB1, E4PD_ECOK1;  Q0TDS9, E4PD_ECOL5;  P0A9B7, E4PD_ECOL6;  
B1IT76, E4PD_ECOLC;  P0A9B6, E4PD_ECOLI;  B7N7H3, E4PD_ECOLU;  
B6I761, E4PD_ECOSE;  B1LDD2, E4PD_ECOSM;  Q1R7A6, E4PD_ECOUT;  
C5BAU7, E4PD_EDWI9;  A4WE72, E4PD_ENT38;  B2VF24, E4PD_ERWT9;  
B7LPD5, E4PD_ESCF3;  Q5QVL6, E4PD_IDILO;  B5XUB7, E4PD_KLEP3;  
A6TDT2, E4PD_KLEP7;  Q6D086, E4PD_PECAS;  C6DFH8, E4PD_PECCP;  
Q7N7Z6, E4PD_PHOLL;  Q6LMN0, E4PD_PHOPR;  B4EUH7, E4PD_PROMH;  
Q15QK3, E4PD_PSEA6;  Q3ILL8, E4PD_PSET1;  A1SVN9, E4PD_PSYIN;  
B5F5J5, E4PD_SALA4;  A9MRF0, E4PD_SALAR;  Q57K44, E4PD_SALCH;  
B5FUI3, E4PD_SALDC;  B5QXJ7, E4PD_SALEP;  B5RE31, E4PD_SALG2;  
B4THF4, E4PD_SALHS;  B4T5H2, E4PD_SALNS;  Q5PJI5, E4PD_SALPA;  
A9N3Q6, E4PD_SALPB;  C0PY46, E4PD_SALPC;  B5BFN5, E4PD_SALPK;  
B4TV39, E4PD_SALSV;  Q8XGA4, E4PD_SALTI;  Q7CPU5, E4PD_SALTY;  
A1S9A4, E4PD_SHEAM;  B8E5U5, E4PD_SHEB2;  Q12QA4, E4PD_SHEDO;  
Q087Q7, E4PD_SHEFN;  B0TUC0, E4PD_SHEHH;  A3QAX7, E4PD_SHELP;  
Q8EIB2, E4PD_SHEON;  A8H0M9, E4PD_SHEPA;  A4Y3R9, E4PD_SHEPC;  
B8CU41, E4PD_SHEPW;  A0L0K7, E4PD_SHESA;  Q0HM63, E4PD_SHESM;  
Q0HRM3, E4PD_SHESR;  A1RN69, E4PD_SHESW;  B2U0U3, E4PD_SHIB3;  
Q31WI6, E4PD_SHIBS;  Q32BY7, E4PD_SHIDS;  Q0T0X3, E4PD_SHIF8;  
P0A9B9, E4PD_SHIFL;  Q3YXU5, E4PD_SHISS;  C4L9J3, E4PD_TOLAT;  
A7MTQ2, E4PD_VIBC1;  A5F9G1, E4PD_VIBC3;  P0C6C2, E4PD_VIBCH;  
Q87LL0, E4PD_VIBPA;  Q8DCA1, E4PD_VIBVU;  Q7MHL0, E4PD_VIBVY;  
A1JPR1, E4PD_YERE8;  Q1CB62, E4PD_YERPA;  Q7CGS4, E4PD_YERPE;  
Q1CEY2, E4PD_YERPN;  Q666Q0, E4PD_YERPS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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