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ENZYME

ENZYME entry: EC 2.6.99.2

Accepted Name
pyridoxine 5'-phosphate synthase
Alternative Name(s)
PNP synthase
pyridoxine 5-phosphate phospho lyase
Reaction catalysed
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate
Comment(s)
  • In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
  • 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate.
Cross-references
BRENDA2.6.99.2
EC2PDB2.6.99.2
ExplorEnz2.6.99.2
PRIAM enzyme-specific profiles2.6.99.2
KEGG Ligand Database for Enzyme Nomenclature2.6.99.2
IUBMB Enzyme Nomenclature2.6.99.2
IntEnz2.6.99.2
MEDLINEFind literature relating to 2.6.99.2
MetaCyc2.6.99.2
Rhea expert-curated reactions2.6.99.2
UniProtKB/Swiss-Prot
B0C977, PDXJ_ACAM1Q3V7G6, PDXJ_ACIADB7J9K4, PDXJ_ACIF2
B5EQL6, PDXJ_ACIF5Q8UDU5, PDXJ_AGRFCB2URE7, PDXJ_AKKM8
Q21XM2, PDXJ_ALBFTQ0VP22, PDXJ_ALCBSA8ESJ1, PDXJ_ALIB4
Q5E317, PDXJ_ALIF1B9JXN7, PDXJ_ALLAMQ3V7J9, PDXJ_ANAMM
Q2GJT4, PDXJ_ANAPZO67417, PDXJ_AQUAEP46212, PDXJ_AQUPY
Q5P083, PDXJ_AROAEA1K607, PDXJ_AZOSBC1DQS7, PDXJ_AZOVD
Q5L912, PDXJ_BACFNQ3V814, PDXJ_BACFRQ8A0V3, PDXJ_BACTN
Q3V7R4, PDXJ_BDEBAQ7VRR1, PDXJ_BLOFLQ492D2, PDXJ_BLOPB
Q2KXM4, PDXJ_BORA1Q7WH63, PDXJ_BORBRQ7W9J7, PDXJ_BORPA
A9IUY4, PDXJ_BORPDQ7VWW0, PDXJ_BORPEO69158, PDXJ_BRADU
A4YWD1, PDXJ_BRASOB2S6L0, PDXJ_BRUA1Q2YQM7, PDXJ_BRUA2
A6WZX2, PDXJ_BRUA4Q57CC2, PDXJ_BRUABA9M642, PDXJ_BRUC2
C0RE25, PDXJ_BRUMBQ8YI24, PDXJ_BRUMEA5VRD3, PDXJ_BRUO2
B0CHH2, PDXJ_BRUSIQ8FZT6, PDXJ_BRUSUQ39I70, PDXJ_BURL3
Q3V7M2, PDXJ_BURMAQ3JQ80, PDXJ_BURP1Q3V7S9, PDXJ_BURPS
A0RNS2, PDXJ_CAMFFA7I3Y5, PDXJ_CAMHCA8FMU3, PDXJ_CAMJ8
A7H2E1, PDXJ_CAMJDQ9PN59, PDXJ_CAMJEA1W0M1, PDXJ_CAMJJ
Q5HTM5, PDXJ_CAMJRB9KCG6, PDXJ_CAMLRB0T3H6, PDXJ_CAUSK
Q9A808, PDXJ_CAUVCB8H623, PDXJ_CAUVNA3PGF5, PDXJ_CERS1
Q3J5W4, PDXJ_CERS4Q11I86, PDXJ_CHESBQ3ATB8, PDXJ_CHLCH
Q3B5P7, PDXJ_CHLL3B3QQ93, PDXJ_CHLP8B3ELU3, PDXJ_CHLPB
A1BE95, PDXJ_CHLPDA4SDF7, PDXJ_CHLPMB3QTV1, PDXJ_CHLT3
Q8KFJ5, PDXJ_CHLTEA0LXW0, PDXJ_CHRFKQ7NWC0, PDXJ_CHRVO
B5EHA6, PDXJ_CITBBQ47WP8, PDXJ_COLP3A9KFA7, PDXJ_COXBN
A9N936, PDXJ_COXBRQ83BL1, PDXJ_COXBUB1WY64, PDXJ_CROS5
Q1LKN4, PDXJ_CUPMCQ0K8N6, PDXJ_CUPNHQ46Z21, PDXJ_CUPPJ
B3R1Z6, PDXJ_CUPTRB8HKL1, PDXJ_CYAP4Q11PM4, PDXJ_CYTH3
Q47EF4, PDXJ_DECARC0Q9S7, PDXJ_DESAHB8FJ89, PDXJ_DESAL
A8ZVC5, PDXJ_DESOHP0A795, PDXJ_ECO57Q8FF18, PDXJ_ECOL6
P0A794, PDXJ_ECOLIQ3YSI5, PDXJ_EHRCJQ2GG30, PDXJ_EHRCR
Q5FHH4, PDXJ_EHRRGQ5HBN7, PDXJ_EHRRWB2KEC4, PDXJ_ELUMP
A5FJ95, PDXJ_FLAJ1B9M5K2, PDXJ_GEODFQ39UG0, PDXJ_GEOMG
Q3V8C9, PDXJ_GEOSLC6E5P6, PDXJ_GEOSMA5G535, PDXJ_GEOUR
B7K7E4, PDXJ_GLOC7Q7NPF2, PDXJ_GLOVIQ5FNS2, PDXJ_GLUOX
Q17ZN1, PDXJ_HELAHQ7VHV1, PDXJ_HELHPB6JP91, PDXJ_HELP2
B5Z9L2, PDXJ_HELPGQ1CR25, PDXJ_HELPHQ9ZJ29, PDXJ_HELPJ
B2UVZ8, PDXJ_HELPSO26102, PDXJ_HELPYQ31HP0, PDXJ_HYDCU
B4U872, PDXJ_HYDS0Q5R109, PDXJ_IDILOQ28V29, PDXJ_JANSC
C1D7L7, PDXJ_LARHHQ3V7G1, PDXJ_LEGPAA5IFW5, PDXJ_LEGPC
Q3V870, PDXJ_LEGPHQ3V7F6, PDXJ_LEGPLB0SBH6, PDXJ_LEPBA
B0SJ25, PDXJ_LEPBPA0L8S5, PDXJ_MAGMMC6BV77, PDXJ_MARSD
Q3V8A2, PDXJ_METCAB3DF93, PDXJ_MICANB9LAE4, PDXJ_NAUPA
Q5F6P1, PDXJ_NEIG1A9M276, PDXJ_NEIM0Q9RQV9, PDXJ_NEIMA
Q9K0V9, PDXJ_NEIMBQ9RML6, PDXJ_NEIMCA1KVH8, PDXJ_NEIMF
Q0AF72, PDXJ_NITECQ82SJ7, PDXJ_NITEUQ2Y865, PDXJ_NITMU
Q3JCY8, PDXJ_NITOCA6Q3Y6, PDXJ_NITSBQ3V891, PDXJ_NITV2
A1VCV9, PDXJ_NITV4B8DPF1, PDXJ_NITV9Q3SRB0, PDXJ_NITWN
B2J448, PDXJ_NOSP7Q8Z080, PDXJ_NOSS1Q30ZQ6, PDXJ_OLEA2
B1ZNA6, PDXJ_OPITPA6LC86, PDXJ_PARD8Q7U7S1, PDXJ_PARMW
Q3V7N3, PDXJ_PECASB4SDS5, PDXJ_PELPBA1AR94, PDXJ_PELPD
Q4FLS6, PDXJ_PELUBC0QU74, PDXJ_PERMHQ7N1X8, PDXJ_PHOLL
Q3V7I6, PDXJ_PHOPRA6KXM3, PDXJ_PHOV8B2RIJ5, PDXJ_PORG3
Q51843, PDXJ_PORGIB4S3G9, PDXJ_PROA2A2C3H1, PDXJ_PROM1
A8G5H7, PDXJ_PROM2A2C897, PDXJ_PROM3A9BAZ9, PDXJ_PROM4
A2BX94, PDXJ_PROM5Q31AB8, PDXJ_PROM9Q7VBK3, PDXJ_PROMA
Q7V6Q5, PDXJ_PROMMQ7V0Y7, PDXJ_PROMPA2BRT6, PDXJ_PROMS
Q46K45, PDXJ_PROMTQ48EV6, PDXJ_PSE14A6VAK3, PDXJ_PSEA7
B7UYW9, PDXJ_PSEA8Q02HS5, PDXJ_PSEABQ9I5G5, PDXJ_PSEAE
Q1I5W1, PDXJ_PSEE4Q4KHS8, PDXJ_PSEF5C3K6Z0, PDXJ_PSEFS
A4XSC7, PDXJ_PSEMYA5W8E9, PDXJ_PSEP1Q3KHL6, PDXJ_PSEPF
B0KV24, PDXJ_PSEPGQ88MY2, PDXJ_PSEPKB1J4E3, PDXJ_PSEPW
Q87XG4, PDXJ_PSESMQ3IDK9, PDXJ_PSET1Q4ZPE4, PDXJ_PSEU2
Q4FUV3, PDXJ_PSYA2Q1QDV0, PDXJ_PSYCKQ8Y0H8, PDXJ_RALN1
B2U984, PDXJ_RALPJQ98KL6, PDXJ_RHILOQ92NT6, PDXJ_RHIME
Q7UYK5, PDXJ_RHOBAQ2IWU8, PDXJ_RHOP2Q3V7S0, PDXJ_RHOPA
Q214J9, PDXJ_RHOPBQ136W2, PDXJ_RHOPSB3QJH1, PDXJ_RHOPT
Q2RT91, PDXJ_RHORTQ16AJ0, PDXJ_ROSDOQ3V7J3, PDXJ_RUEPO
Q57LD3, PDXJ_SALCHQ3V7K1, PDXJ_SALPAQ2S0U5, PDXJ_SALRD
Q8Z4K6, PDXJ_SALTIQ8ZN19, PDXJ_SALTYQ8EH78, PDXJ_SHEON
Q31XS3, PDXJ_SHIBSQ32CV7, PDXJ_SHIDSQ3YYV2, PDXJ_SHISS
C4XGU0, PDXJ_SOLM1A4VIX8, PDXJ_STUS1Q30S57, PDXJ_SULDN
A6QAX8, PDXJ_SULNBB2V6U1, PDXJ_SULSYQ3A5V4, PDXJ_SYNC1
Q8KPR0, PDXJ_SYNE7A0LK96, PDXJ_SYNFMQ2JSG7, PDXJ_SYNJA
Q2JP46, PDXJ_SYNJBQ3V812, PDXJ_SYNP6A5GLI2, PDXJ_SYNPW
A5GU97, PDXJ_SYNR3Q0IB11, PDXJ_SYNS3Q3AVH3, PDXJ_SYNS9
Q3AJ26, PDXJ_SYNSCP72776, PDXJ_SYNY3Q8DKM1, PDXJ_THEVB
B5YGR4, PDXJ_THEYDQ3SH53, PDXJ_THIDAB8GPL4, PDXJ_THISH
Q10X41, PDXJ_TRIEIB3E693, PDXJ_TRIL1Q3M9L4, PDXJ_TRIV2
Q9KPB5, PDXJ_VIBCHQ87LP2, PDXJ_VIBPAQ8DC73, PDXJ_VIBVU
Q7MHP1, PDXJ_VIBVYQ8D304, PDXJ_WIGBRQ3V8B3, PDXJ_WOLPM
B3CLF3, PDXJ_WOLPPQ7MAP8, PDXJ_WOLSUC0R576, PDXJ_WOLWR
Q8PRF1, PDXJ_XANACQ4V0R7, PDXJ_XANC8B0RLF1, PDXJ_XANCB
Q8PEG8, PDXJ_XANCPQ3BZR9, PDXJ_XANE5Q2P9L0, PDXJ_XANOM
B2SUX4, PDXJ_XANOPQ5H704, PDXJ_XANORA7IM59, PDXJ_XANP2
B2I669, PDXJ_XYLF2Q9PH84, PDXJ_XYLFAB0U2A9, PDXJ_XYLFM
Q87F88, PDXJ_XYLFTQ8ZCP4, PDXJ_YERPEQ3V7P0, PDXJ_YERPS
Q5NLS8, PDXJ_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-