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ENZYME

ENZYME entry: EC 2.3.1.12

Accepted Name
dihydrolipoyllysine-residue acetyltransferase
Alternative Name(s)
acetyl-CoA:dihydrolipoamide S-acetyltransferase
dihydrolipoamide S-acetyltransferase
dihydrolipoate acetyltransferase
dihydrolipoic transacetylase
dihydrolipoyl acetyltransferase
lipoate acetyltransferase
lipoate transacetylase
lipoic acetyltransferase
lipoic acid acetyltransferase
lipoic transacetylase
lipoylacetyltransferase
thioltransacetylase A
transacetylase X
Reaction catalysed
(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA
Comment(s)
  • A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.
Cross-references
BRENDA2.3.1.12
EC2PDB2.3.1.12
ExplorEnz2.3.1.12
PRIAM enzyme-specific profiles2.3.1.12
KEGG Ligand Database for Enzyme Nomenclature2.3.1.12
IUBMB Enzyme Nomenclature2.3.1.12
IntEnz2.3.1.12
MEDLINEFind literature relating to 2.3.1.12
MetaCyc2.3.1.12
Rhea expert-curated reactions2.3.1.12
UniProtKB/Swiss-Prot
O31550, ACOC_BACSUP27747, ACOC_CUPNHQ59695, ACOC_PSEPU
Q0WQF7, ODP21_ARATHQ8RWN9, ODP22_ARATHQ5M729, ODP23_ARATH
Q9SQI8, ODP24_ARATHQ9C8P0, ODP25_ARATHP35489, ODP2_ACHLA
P10802, ODP2_AZOVIP21883, ODP2_BACSUP11180, ODP2_BOVIN
P57302, ODP2_BUCAIQ8K9T8, ODP2_BUCAPQ89AQ9, ODP2_BUCBP
Q19749, ODP2_CAEELG0S4X6, ODP2_CHATDQ8NNJ2, ODP2_CORGL
Q59098, ODP2_CUPNHP36413, ODP2_DICDIP06959, ODP2_ECOLI
P11961, ODP2_GEOSEP45118, ODP2_HAEINP10515, ODP2_HUMAN
Q6ABX9, ODP2_LEIXXP86197, ODP2_MESAUQ8BMF4, ODP2_MOUSE
P65634, ODP2_MYCBOQ49110, ODP2_MYCCTP47514, ODP2_MYCGE
P75392, ODP2_MYCPNP9WIS6, ODP2_MYCTOP9WIS7, ODP2_MYCTU
P20285, ODP2_NEUCRQ59638, ODP2_PSEAEP08461, ODP2_RAT
Q9R9N3, ODP2_RHIMEQ1RJT3, ODP2_RICBRQ92HK7, ODP2_RICCN
Q4ULG1, ODP2_RICFEQ9ZD20, ODP2_RICPRQ68WK6, ODP2_RICTY
O59816, ODP2_SCHPOP81421, ODP2_SOLTUQ5HGY9, ODP2_STAAC
P65635, ODP2_STAAMP65636, ODP2_STAANQ6GHZ0, ODP2_STAAR
Q6GAB9, ODP2_STAASQ59821, ODP2_STAAUQ8NX76, ODP2_STAAW
Q5HQ74, ODP2_STAEQQ8CT13, ODP2_STAESP12695, ODP2_YEAST
O66119, ODP2_ZYMMOP81420, ODP3_SOLTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
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