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ENZYME entry: EC 2.3.1.12

Accepted Name
Dihydrolipoyllysine-residue acetyltransferase.
Alternative Name(s)
Acetyl-CoA:dihydrolipoamide S-acetyltransferase.
Dihydrolipoamide S-acetyltransferase.
Dihydrolipoate acetyltransferase.
Dihydrolipoic transacetylase.
Dihydrolipoyl acetyltransferase.
Lipoate acetyltransferase.
Lipoate transacetylase.
Lipoic acetyltransferase.
Lipoic acid acetyltransferase.
Lipoic transacetylase.
Lipoylacetyltransferase.
Thioltransacetylase A.
Transacetylase X.
Reaction catalysed
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Comment(s)
  • A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.
Cross-references
BRENDA2.3.1.12
EC2PDB2.3.1.12
ExplorEnz2.3.1.12
PRIAM enzyme-specific profiles2.3.1.12
KEGG Ligand Database for Enzyme Nomenclature2.3.1.12
IUBMB Enzyme Nomenclature2.3.1.12
IntEnz2.3.1.12
MEDLINEFind literature relating to 2.3.1.12
MetaCyc2.3.1.12
UniProtKB/Swiss-Prot
O31550, ACOC_BACSU;  P27747, ACOC_CUPNH;  Q59695, ACOC_PSEPU;  
Q0WQF7, ODP21_ARATH;  Q8RWN9, ODP22_ARATH;  Q5M729, ODP23_ARATH;  
Q9SQI8, ODP24_ARATH;  Q9C8P0, ODP25_ARATH;  P35489, ODP2_ACHLA;  
P10802, ODP2_AZOVI;  P21883, ODP2_BACSU;  P11180, ODP2_BOVIN;  
P57302, ODP2_BUCAI;  Q8K9T8, ODP2_BUCAP;  Q89AQ9, ODP2_BUCBP;  
Q19749, ODP2_CAEEL;  Q8NNJ2, ODP2_CORGL;  Q59098, ODP2_CUPNH;  
P36413, ODP2_DICDI;  P06959, ODP2_ECOLI;  P11961, ODP2_GEOSE;  
P45118, ODP2_HAEIN;  P10515, ODP2_HUMAN;  Q6ABX9, ODP2_LEIXX;  
P86197, ODP2_MESAU;  Q8BMF4, ODP2_MOUSE;  P65634, ODP2_MYCBO;  
Q49110, ODP2_MYCCT;  P47514, ODP2_MYCGE;  P75392, ODP2_MYCPN;  
P9WIS6, ODP2_MYCTO;  P9WIS7, ODP2_MYCTU;  P20285, ODP2_NEUCR;  
Q59638, ODP2_PSEAE;  P08461, ODP2_RAT;  Q9R9N3, ODP2_RHIME;  
Q1RJT3, ODP2_RICBR;  Q92HK7, ODP2_RICCN;  Q4ULG1, ODP2_RICFE;  
Q9ZD20, ODP2_RICPR;  Q68WK6, ODP2_RICTY;  O59816, ODP2_SCHPO;  
P81421, ODP2_SOLTU;  Q5HGY9, ODP2_STAAC;  P65635, ODP2_STAAM;  
P65636, ODP2_STAAN;  Q6GHZ0, ODP2_STAAR;  Q6GAB9, ODP2_STAAS;  
Q59821, ODP2_STAAU;  Q8NX76, ODP2_STAAW;  Q5HQ74, ODP2_STAEQ;  
Q8CT13, ODP2_STAES;  P12695, ODP2_YEAST;  O66119, ODP2_ZYMMO;  
P81420, ODP3_SOLTU;  

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