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ENZYME

ENZYME entry: EC 2.3.1.12

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.12
Accepted Name
dihydrolipoyllysine-residue acetyltransferase
Alternative Name(s)
acetyl-CoA:dihydrolipoamide S-acetyltransferase
dihydrolipoamide S-acetyltransferase
dihydrolipoate acetyltransferase
dihydrolipoic transacetylase
dihydrolipoyl acetyltransferase
lipoate acetyltransferase
lipoate transacetylase
lipoic acetyltransferase
lipoic acid acetyltransferase
lipoic transacetylase
lipoylacetyltransferase
thioltransacetylase A
transacetylase X
Reaction catalysed
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA
Comment(s)
  • A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.
Cross-references
BRENDA2.3.1.12
EC2PDB2.3.1.12
ExplorEnz2.3.1.12
KEGG Ligand Database for Enzyme Nomenclature2.3.1.12
IUBMB Enzyme Nomenclature2.3.1.12
MEDLINEFind literature relating to 2.3.1.12
MetaCyc2.3.1.12
Rhea expert-curated reactions2.3.1.12
UniProtKB/Swiss-Prot
O31550, ACOC_BACSUP27747, ACOC_CUPNHQ59695, ACOC_PSEPU
Q0WQF7, ODP21_ARATHQ8RWN9, ODP22_ARATHQ5M729, ODP23_ARATH
Q9SQI8, ODP24_ARATHQ9C8P0, ODP25_ARATHP35489, ODP2_ACHLA
P10802, ODP2_AZOVIP21883, ODP2_BACSUP11180, ODP2_BOVIN
P57302, ODP2_BUCAIQ8K9T8, ODP2_BUCAPQ89AQ9, ODP2_BUCBP
Q19749, ODP2_CAEELG0S4X6, ODP2_CHATDQ8NNJ2, ODP2_CORGL
Q59098, ODP2_CUPNHP36413, ODP2_DICDIP06959, ODP2_ECOLI
A0A0D2Y5A7, ODP2_FUSO4P11961, ODP2_GEOSEP45118, ODP2_HAEIN
P10515, ODP2_HUMANQ6ABX9, ODP2_LEIXXP86197, ODP2_MESAU
Q8BMF4, ODP2_MOUSEP65634, ODP2_MYCBOQ49110, ODP2_MYCCT
P47514, ODP2_MYCGEP75392, ODP2_MYCPNP9WIS6, ODP2_MYCTO
P9WIS7, ODP2_MYCTUP20285, ODP2_NEUCRQ59638, ODP2_PSEAE
P08461, ODP2_RATQ9R9N3, ODP2_RHIMEQ1RJT3, ODP2_RICBR
Q92HK7, ODP2_RICCNQ4ULG1, ODP2_RICFEQ9ZD20, ODP2_RICPR
Q68WK6, ODP2_RICTYO59816, ODP2_SCHPOP81421, ODP2_SOLTU
Q5HGY9, ODP2_STAACP65635, ODP2_STAAMP65636, ODP2_STAAN
Q6GHZ0, ODP2_STAARQ6GAB9, ODP2_STAASQ59821, ODP2_STAAU
Q8NX76, ODP2_STAAWQ5HQ74, ODP2_STAEQQ8CT13, ODP2_STAES
P12695, ODP2_YEASTO66119, ODP2_ZYMMOP81420, ODP3_SOLTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-