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ENZYME entry: EC 1.2.4.2

Accepted Name
Oxoglutarate dehydrogenase (succinyl-transferring).
Alternative Name(s)
2-ketoglutarate dehydrogenase.
2-oxoglutarate dehydrogenase.
2-oxoglutarate: lipoate oxidoreductase.
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor- succinylating).
AKGDH.
Alpha-ketoglutarate dehydrogenase.
Alpha-ketoglutaric acid dehydrogenase.
Alpha-ketoglutaric dehydrogenase.
Alpha-oxoglutarate dehydrogenase.
Ketoglutaric dehydrogenase.
OGDC.
Oxoglutarate decarboxylase.
Oxoglutarate dehydrogenase.
Oxoglutarate dehydrogenase (lipoamide).
Reaction catalysed
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine <=> [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
Cross-references
BRENDA1.2.4.2
EC2PDB1.2.4.2
ExplorEnz1.2.4.2
PRIAM enzyme-specific profiles1.2.4.2
KEGG Ligand Database for Enzyme Nomenclature1.2.4.2
IUBMB Enzyme Nomenclature1.2.4.2
IntEnz1.2.4.2
MEDLINEFind literature relating to 1.2.4.2
MetaCyc1.2.4.2
UniProtKB/Swiss-Prot
Q23629, DHTK1_CAEEL;  Q5PRA2, DHTK1_DANRE;  Q54VG0, DHTK1_DICDI;  
Q9VA02, DHTK1_DROME;  Q96HY7, DHTK1_HUMAN;  A2ATU0, DHTK1_MOUSE;  
Q5R7H0, DHTK1_PONAB;  Q4KLP0, DHTK1_RAT;  Q6P286, DHTK1_XENLA;  
Q7U0A6, KGD_MYCBO;  A1KI36, KGD_MYCBP;  Q9CC97, KGD_MYCLE;  
Q73WX4, KGD_MYCPA;  A0R2B1, KGD_MYCS2;  A3Q3N5, KGD_MYCSJ;  
A1UK81, KGD_MYCSK;  Q1B4V6, KGD_MYCSS;  A5U1U6, KGD_MYCTA;  
P9WIS4, KGD_MYCTO;  P9WIS5, KGD_MYCTU;  A0PVU7, KGD_MYCUA;  
A1TDK2, KGD_MYCVP;  Q8NRC3, ODO12_CORGL;  P20707, ODO1_AZOVI;  
C3P487, ODO1_BACAA;  C3LAU3, ODO1_BACAC;  Q81TK1, ODO1_BACAN;  
B7JEU9, ODO1_BACC0;  Q73BN8, ODO1_BACC1;  B7IM94, ODO1_BACC2;  
C1ELG5, ODO1_BACC3;  B7HH19, ODO1_BACC4;  B7I0H2, ODO1_BACC7;  
A7GMD4, ODO1_BACCN;  B9IU58, ODO1_BACCQ;  Q81GF2, ODO1_BACCR;  
Q63EB1, ODO1_BACCZ;  Q9KAT1, ODO1_BACHD;  Q6HLS8, ODO1_BACHK;  
Q65IH4, ODO1_BACLD;  A9VJX9, ODO1_BACMK;  A8FE66, ODO1_BACP2;  
Q5WG56, ODO1_BACSK;  P23129, ODO1_BACSU;  A7Z5J9, ODO1_BACVZ;  
Q148N0, ODO1_BOVIN;  B2S877, ODO1_BRUA1;  Q2YLS2, ODO1_BRUA2;  
Q57AX5, ODO1_BRUAB;  A9M8Q9, ODO1_BRUC2;  C0RFG8, ODO1_BRUMB;  
Q8YJE4, ODO1_BRUME;  A5VSQ0, ODO1_BRUO2;  B0CIS7, ODO1_BRUSI;  
Q8FYF7, ODO1_BRUSU;  P57388, ODO1_BUCAI;  Q8K9N3, ODO1_BUCAP;  
Q89AJ7, ODO1_BUCBP;  Q623T0, ODO1_CAEBR;  O61199, ODO1_CAEEL;  
P51056, ODO1_COXBU;  Q59106, ODO1_CUPNH;  Q54JE4, ODO1_DICDI;  
P0AFG5, ODO1_ECO57;  P0AFG4, ODO1_ECOL6;  P0AFG3, ODO1_ECOLI;  
C4L3W2, ODO1_EXISA;  Q5L172, ODO1_GEOKA;  C5D802, ODO1_GEOSW;  
P45303, ODO1_HAEIN;  Q02218, ODO1_HUMAN;  Q72PJ7, ODO1_LEPIC;  
Q8F6S7, ODO1_LEPIN;  Q60HE2, ODO1_MACFA;  P86231, ODO1_MESAU;  
Q60597, ODO1_MOUSE;  Q8CUL8, ODO1_OCEIH;  A6WXF0, ODO1_OCHA4;  
Q5RCB8, ODO1_PONAB;  Q5XI78, ODO1_RAT;  Q1RHI4, ODO1_RICBR;  
Q92J42, ODO1_RICCN;  Q4UKI8, ODO1_RICFE;  Q9ZDY3, ODO1_RICPR;  
Q68XI7, ODO1_RICTY;  O74378, ODO1_SCHPO;  P81895, ODO1_SOLTU;  
A7X295, ODO1_STAA1;  A6U1N4, ODO1_STAA2;  Q2FH25, ODO1_STAA3;  
Q2FYM1, ODO1_STAA8;  A5ISU5, ODO1_STAA9;  Q2YY05, ODO1_STAAB;  
Q5HG06, ODO1_STAAC;  A6QGW6, ODO1_STAAE;  Q931R8, ODO1_STAAM;  
Q99U74, ODO1_STAAN;  Q6GGZ5, ODO1_STAAR;  Q6G9E8, ODO1_STAAS;  
A8Z3Z0, ODO1_STAAT;  P0C601, ODO1_STAAU;  Q8NWR6, ODO1_STAAW;  
Q5HPC6, ODO1_STAEQ;  Q8CP83, ODO1_STAES;  Q4L6C4, ODO1_STAHJ;  
Q49XM5, ODO1_STAS1;  Q6P6Z8, ODO1_XENLA;  P20967, ODO1_YEAST;  

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