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ENZYME

ENZYME entry: EC 1.2.4.2

Accepted Name
oxoglutarate dehydrogenase (succinyl-transferring)
Alternative Name(s)
2-ketoglutarate dehydrogenase
2-oxoglutarate dehydrogenase
AKGDH
alpha-ketoglutarate dehydrogenase
alpha-ketoglutaric acid dehydrogenase
alpha-ketoglutaric dehydrogenase
alpha-oxoglutarate dehydrogenase
ketoglutaric dehydrogenase
OGDC
oxoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)
Reaction catalysed
2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]
Comment(s)
  • It is a component of EC 1.2.1.105 in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
  • It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
Cross-references
BRENDA1.2.4.2
EC2PDB1.2.4.2
ExplorEnz1.2.4.2
PRIAM enzyme-specific profiles1.2.4.2
KEGG Ligand Database for Enzyme Nomenclature1.2.4.2
IUBMB Enzyme Nomenclature1.2.4.2
IntEnz1.2.4.2
MEDLINEFind literature relating to 1.2.4.2
MetaCyc1.2.4.2
Rhea expert-curated reactions1.2.4.2
UniProtKB/Swiss-Prot
Q7U0A6, KGD_MYCBOA1KI36, KGD_MYCBPQ9CC97, KGD_MYCLE
Q73WX4, KGD_MYCPAA0R2B1, KGD_MYCS2A3Q3N5, KGD_MYCSJ
A1UK81, KGD_MYCSKQ1B4V6, KGD_MYCSSA5U1U6, KGD_MYCTA
P9WIS4, KGD_MYCTOP9WIS5, KGD_MYCTUA0PVU7, KGD_MYCUA
A1TDK2, KGD_MYCVPQ8NRC3, ODO12_CORGLP20707, ODO1_AZOVI
C3P487, ODO1_BACAAC3LAU3, ODO1_BACACQ81TK1, ODO1_BACAN
B7JEU9, ODO1_BACC0Q73BN8, ODO1_BACC1B7IM94, ODO1_BACC2
C1ELG5, ODO1_BACC3B7HH19, ODO1_BACC4B7I0H2, ODO1_BACC7
A7GMD4, ODO1_BACCNB9IU58, ODO1_BACCQQ81GF2, ODO1_BACCR
Q63EB1, ODO1_BACCZQ6HLS8, ODO1_BACHKQ65IH4, ODO1_BACLD
A9VJX9, ODO1_BACMKA8FE66, ODO1_BACP2P23129, ODO1_BACSU
A7Z5J9, ODO1_BACVZQ148N0, ODO1_BOVINB2S877, ODO1_BRUA1
Q2YLS2, ODO1_BRUA2A6WXF0, ODO1_BRUA4Q57AX5, ODO1_BRUAB
A9M8Q9, ODO1_BRUC2C0RFG8, ODO1_BRUMBQ8YJE4, ODO1_BRUME
A5VSQ0, ODO1_BRUO2B0CIS7, ODO1_BRUSIQ8FYF7, ODO1_BRUSU
P57388, ODO1_BUCAIQ8K9N3, ODO1_BUCAPQ89AJ7, ODO1_BUCBP
Q623T0, ODO1_CAEBRO61199, ODO1_CAEELP51056, ODO1_COXBU
Q59106, ODO1_CUPNHQ54JE4, ODO1_DICDIP0AFG5, ODO1_ECO57
P0AFG4, ODO1_ECOL6P0AFG3, ODO1_ECOLIC4L3W2, ODO1_EXISA
Q5L172, ODO1_GEOKAC5D802, ODO1_GEOSWP45303, ODO1_HAEIN
Q9KAT1, ODO1_HALH5Q02218, ODO1_HUMANQ72PJ7, ODO1_LEPIC
Q8F6S7, ODO1_LEPINQ60HE2, ODO1_MACFAP86231, ODO1_MESAU
Q60597, ODO1_MOUSEQ8CUL8, ODO1_OCEIHQ5RCB8, ODO1_PONAB
Q5XI78, ODO1_RATQ1RHI4, ODO1_RICBRQ92J42, ODO1_RICCN
Q4UKI8, ODO1_RICFEQ9ZDY3, ODO1_RICPRQ68XI7, ODO1_RICTY
O74378, ODO1_SCHPOQ5WG56, ODO1_SHOC1P81895, ODO1_SOLTU
A7X295, ODO1_STAA1A6U1N4, ODO1_STAA2Q2FH25, ODO1_STAA3
Q2FYM1, ODO1_STAA8A5ISU5, ODO1_STAA9Q2YY05, ODO1_STAAB
Q5HG06, ODO1_STAACA6QGW6, ODO1_STAAEQ931R8, ODO1_STAAM
Q99U74, ODO1_STAANQ6GGZ5, ODO1_STAARQ6G9E8, ODO1_STAAS
A8Z3Z0, ODO1_STAATP0C601, ODO1_STAAUQ8NWR6, ODO1_STAAW
Q5HPC6, ODO1_STAEQQ8CP83, ODO1_STAESQ4L6C4, ODO1_STAHJ
Q49XM5, ODO1_STAS1Q6P6Z8, ODO1_XENLAP20967, ODO1_YEAST
Q9ULD0, OGDHL_HUMANQ5R9L8, OGDHL_PONABD3ZQD3, OGDHL_RAT
Q68EW0, OGDHL_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.4.-
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