ENZYME entry: EC 1.2.4.2

Accepted Name

oxoglutarate dehydrogenase (succinyl-transferring)

Alternative Name(s)

2-ketoglutarate dehydrogenase

2-oxoglutarate dehydrogenase

AKGDH

alpha-ketoglutarate dehydrogenase

alpha-ketoglutaric acid dehydrogenase

alpha-ketoglutaric dehydrogenase

alpha-oxoglutarate dehydrogenase

ketoglutaric dehydrogenase

OGDC

oxoglutarate dehydrogenase

oxoglutarate dehydrogenase (lipoamide)

Reaction catalysed

(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2

Comment(s)

It is a component of EC 1.2.1.105 in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4.
It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.

Cross-references

BRENDA

1.2.4.2

EC2PDB

1.2.4.2

ExplorEnz

1.2.4.2

PRIAM enzyme-specific profiles

1.2.4.2

KEGG Ligand Database for Enzyme Nomenclature

1.2.4.2

IUBMB Enzyme Nomenclature

1.2.4.2

IntEnz

1.2.4.2

MEDLINE

Find literature relating to 1.2.4.2

MetaCyc

1.2.4.2

Rhea expert-curated reactions

1.2.4.2

UniProtKB/Swiss-Prot

Q23629, DHTK1_CAEEL	Q54VG0, DHTK1_DICDI	Q9VA02, DHTK1_DROME
Q7U0A6, KGD_MYCBO	A1KI36, KGD_MYCBP	Q9CC97, KGD_MYCLE
Q73WX4, KGD_MYCPA	A0R2B1, KGD_MYCS2	A3Q3N5, KGD_MYCSJ
A1UK81, KGD_MYCSK	Q1B4V6, KGD_MYCSS	A5U1U6, KGD_MYCTA
P9WIS4, KGD_MYCTO	P9WIS5, KGD_MYCTU	A0PVU7, KGD_MYCUA
A1TDK2, KGD_MYCVP	Q8NRC3, ODO12_CORGL	Q5WG56, ODO1_ALKCK
P20707, ODO1_AZOVI	C3P487, ODO1_BACAA	C3LAU3, ODO1_BACAC
Q81TK1, ODO1_BACAN	B7JEU9, ODO1_BACC0	Q73BN8, ODO1_BACC1
B7IM94, ODO1_BACC2	C1ELG5, ODO1_BACC3	B7HH19, ODO1_BACC4
B7I0H2, ODO1_BACC7	A7GMD4, ODO1_BACCN	B9IU58, ODO1_BACCQ
Q81GF2, ODO1_BACCR	Q63EB1, ODO1_BACCZ	Q6HLS8, ODO1_BACHK
Q65IH4, ODO1_BACLD	A9VJX9, ODO1_BACMK	A8FE66, ODO1_BACP2
P23129, ODO1_BACSU	A7Z5J9, ODO1_BACVZ	Q148N0, ODO1_BOVIN
B2S877, ODO1_BRUA1	Q2YLS2, ODO1_BRUA2	A6WXF0, ODO1_BRUA4
Q57AX5, ODO1_BRUAB	A9M8Q9, ODO1_BRUC2	C0RFG8, ODO1_BRUMB
Q8YJE4, ODO1_BRUME	A5VSQ0, ODO1_BRUO2	B0CIS7, ODO1_BRUSI
Q8FYF7, ODO1_BRUSU	P57388, ODO1_BUCAI	Q8K9N3, ODO1_BUCAP
Q89AJ7, ODO1_BUCBP	Q623T0, ODO1_CAEBR	O61199, ODO1_CAEEL
P51056, ODO1_COXBU	Q59106, ODO1_CUPNH	Q54JE4, ODO1_DICDI
P0AFG5, ODO1_ECO57	P0AFG4, ODO1_ECOL6	P0AFG3, ODO1_ECOLI
C4L3W2, ODO1_EXISA	Q5L172, ODO1_GEOKA	C5D802, ODO1_GEOSW
P45303, ODO1_HAEIN	Q9KAT1, ODO1_HALH5	Q02218, ODO1_HUMAN
Q72PJ7, ODO1_LEPIC	Q8F6S7, ODO1_LEPIN	Q60HE2, ODO1_MACFA
P86231, ODO1_MESAU	Q60597, ODO1_MOUSE	Q8CUL8, ODO1_OCEIH
Q5RCB8, ODO1_PONAB	Q5XI78, ODO1_RAT	Q1RHI4, ODO1_RICBR
Q92J42, ODO1_RICCN	Q4UKI8, ODO1_RICFE	Q9ZDY3, ODO1_RICPR
Q68XI7, ODO1_RICTY	O74378, ODO1_SCHPO	P81895, ODO1_SOLTU
A7X295, ODO1_STAA1	A6U1N4, ODO1_STAA2	Q2FH25, ODO1_STAA3
Q2FYM1, ODO1_STAA8	A5ISU5, ODO1_STAA9	Q2YY05, ODO1_STAAB
Q5HG06, ODO1_STAAC	A6QGW6, ODO1_STAAE	Q931R8, ODO1_STAAM
Q99U74, ODO1_STAAN	Q6GGZ5, ODO1_STAAR	Q6G9E8, ODO1_STAAS
A8Z3Z0, ODO1_STAAT	P0C601, ODO1_STAAU	Q8NWR6, ODO1_STAAW
Q5HPC6, ODO1_STAEQ	Q8CP83, ODO1_STAES	Q4L6C4, ODO1_STAHJ
Q49XM5, ODO1_STAS1	Q6P6Z8, ODO1_XENLA	P20967, ODO1_YEAST
Q9ULD0, OGDHL_HUMAN	Q5R9L8, OGDHL_PONAB	D3ZQD3, OGDHL_RAT
Q68EW0, OGDHL_XENLA

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