Home  |  Contact

ENZYME entry: EC 1.2.1.105

Accepted Name
2-oxoglutarate dehydrogenase system.
Alternative Name(s)
2-oxoglutarate dehydrogenase complex.
Reaction catalysed
2-oxoglutarate + CoA + NAD(+) <=> succinyl-CoA + CO(2) + NADH
Comment(s)
  • The 2-oxoglutarate dehydrogenase system is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, EC 1.2.1.104, EC 1.4.1.27 and EC 2.3.1.190.
  • With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3).
  • This enzyme system converts 2-oxoglutarate to succinyl-CoA and produces NADH and CO(2) in a complicated series of irreversible reactions.
  • The reaction catalyzed by this system is the sum of three activities: EC 1.2.4.2, EC 2.3.1.61 and EC 1.8.1.4.
Cross-references
BRENDA1.2.1.105
EC2PDB1.2.1.105
ExplorEnz1.2.1.105
PRIAM enzyme-specific profiles1.2.1.105
KEGG Ligand Database for Enzyme Nomenclature1.2.1.105
IUBMB Enzyme Nomenclature1.2.1.105
IntEnz1.2.1.105
MEDLINEFind literature relating to 1.2.1.105
MetaCyc1.2.1.105
Rhea expert-curated reactions1.2.1.105

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-