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ENZYME entry: EC 18.104.22.168
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|2-oxoglutarate dehydrogenase system.
|2-oxoglutarate dehydrogenase complex.|
|2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA|
- The 2-oxoglutarate dehydrogenase system is a large enzyme complex
that belongs to the 2-oxoacid dehydrogenase system family, which also
includes EC 22.214.171.124, EC 126.96.36.199, EC 188.8.131.52 and EC 184.108.40.206.
- With the exception of the glycine cleavage system, which contains 4
components, the 2-oxoacid dehydrogenase systems share a common
structure, consisting of three main components, namely a 2-oxoacid
dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a
dihydrolipoamide dehydrogenase (E3).
- This enzyme system converts 2-oxoglutarate to succinyl-CoA and
produces NADH and CO2 in a complicated series of irreversible
- The reaction catalyzed by this system is the sum of three activities:
EC 220.127.116.11, EC 18.104.22.168 and EC 22.214.171.124.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|Rhea expert-curated reactions||18.104.22.168|
entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-