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ENZYME entry: EC 2.3.1.61

Accepted Name
Dihydrolipoyllysine-residue succinyltransferase.
Alternative Name(s)
Dihydrolipoamide S-succinyltransferase.
Dihydrolipoamide succinyltransferase.
Dihydrolipoic transsuccinylase.
Dihydrolipolyl transsuccinylase.
Dihydrolipoyl transsuccinylase.
Lipoate succinyltransferase.
Lipoic transsuccinylase.
Lipoyl transsuccinylase.
Succinyl-CoA:dihydrolipoamide S-succinyltransferase.
Succinyl-CoA:dihydrolipoate S-succinyltransferase.
Reaction catalysed
Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine
Comment(s)
  • A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalyzed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.
Cross-references
BRENDA2.3.1.61
EC2PDB2.3.1.61
ExplorEnz2.3.1.61
PRIAM enzyme-specific profiles2.3.1.61
KEGG Ligand Database for Enzyme Nomenclature2.3.1.61
IUBMB Enzyme Nomenclature2.3.1.61
IntEnz2.3.1.61
MEDLINEFind literature relating to 2.3.1.61
MetaCyc2.3.1.61
UniProtKB/Swiss-Prot
Q7U0A6, KGD_MYCBO;  A1KI36, KGD_MYCBP;  Q9CC97, KGD_MYCLE;  
Q73WX4, KGD_MYCPA;  A0R2B1, KGD_MYCS2;  A3Q3N5, KGD_MYCSJ;  
A1UK81, KGD_MYCSK;  Q1B4V6, KGD_MYCSS;  A5U1U6, KGD_MYCTA;  
P9WIS4, KGD_MYCTO;  P9WIS5, KGD_MYCTU;  A0PVU7, KGD_MYCUA;  
A1TDK2, KGD_MYCVP;  Q8NRC3, ODO12_CORGL;  Q9FLQ4, ODO2A_ARATH;  
Q8H107, ODO2B_ARATH;  P20708, ODO2_AZOVI;  P16263, ODO2_BACSU;  
Q6FYD4, ODO2_BARQU;  Q8GCY1, ODO2_BARVB;  P11179, ODO2_BOVIN;  
P57389, ODO2_BUCAI;  Q8K9N2, ODO2_BUCAP;  Q89AJ6, ODO2_BUCBP;  
P52993, ODO2_CUPNH;  P83708, ODO2_DELAC;  Q869Y7, ODO2_DICDI;  
P0AFG7, ODO2_ECO57;  P0AFG6, ODO2_ECOLI;  P45302, ODO2_HAEIN;  
P36957, ODO2_HUMAN;  P86219, ODO2_MESAU;  Q9D2G2, ODO2_MOUSE;  
Q9N0F1, ODO2_PIG;  Q9I3D2, ODO2_PSEAE;  P31051, ODO2_PSEPU;  
Q01205, ODO2_RAT;  Q1RHI5, ODO2_RICBR;  Q92J43, ODO2_RICCN;  
Q4UKI7, ODO2_RICFE;  Q9ZDY4, ODO2_RICPR;  Q68XI8, ODO2_RICTY;  
O94681, ODO2_SCHPO;  P81896, ODO2_SOLTU;  Q2FH26, ODO2_STAA3;  
Q2FYM2, ODO2_STAA8;  Q2YY06, ODO2_STAAB;  Q5HG07, ODO2_STAAC;  
Q99U75, ODO2_STAAM;  Q7A5N4, ODO2_STAAN;  Q6GGZ6, ODO2_STAAR;  
Q6G9E9, ODO2_STAAS;  Q8NWR7, ODO2_STAAW;  Q5HPC7, ODO2_STAEQ;  
Q8CSL9, ODO2_STAES;  Q4L6C3, ODO2_STAHJ;  Q49XM4, ODO2_STAS1;  
Q90512, ODO2_TAKRU;  P19262, ODO2_YEAST;  

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