ENZYME entry: EC 2.3.1.61

Accepted Name

dihydrolipoyllysine-residue succinyltransferase

Alternative Name(s)

dihydrolipoamide S-succinyltransferase

dihydrolipoamide succinyltransferase

dihydrolipoic transsuccinylase

dihydrolipolyl transsuccinylase

dihydrolipoyl transsuccinylase

lipoate succinyltransferase

lipoic transsuccinylase

lipoyl transsuccinylase

succinyl-CoA:dihydrolipoamide S-succinyltransferase

succinyl-CoA:dihydrolipoate S-succinyltransferase

Reaction catalysed

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]

Comment(s)

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2 and EC 1.8.1.4.
The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalyzed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

Cross-references

BRENDA

2.3.1.61

EC2PDB

2.3.1.61

ExplorEnz

2.3.1.61

PRIAM enzyme-specific profiles

2.3.1.61

KEGG Ligand Database for Enzyme Nomenclature

2.3.1.61

IUBMB Enzyme Nomenclature

2.3.1.61

IntEnz

2.3.1.61

MEDLINE

Find literature relating to 2.3.1.61

MetaCyc

2.3.1.61

Rhea expert-curated reactions

2.3.1.61

UniProtKB/Swiss-Prot

Q7U0A6, KGD_MYCBO	A1KI36, KGD_MYCBP	Q9CC97, KGD_MYCLE
Q73WX4, KGD_MYCPA	A0R2B1, KGD_MYCS2	A3Q3N5, KGD_MYCSJ
A1UK81, KGD_MYCSK	Q1B4V6, KGD_MYCSS	A5U1U6, KGD_MYCTA
P9WIS4, KGD_MYCTO	P9WIS5, KGD_MYCTU	A0PVU7, KGD_MYCUA
A1TDK2, KGD_MYCVP	Q8NRC3, ODO12_CORGL	Q9FLQ4, ODO2A_ARATH
Q8H107, ODO2B_ARATH	P20708, ODO2_AZOVI	P16263, ODO2_BACSU
Q6FYD4, ODO2_BARQU	Q8GCY1, ODO2_BARVB	P11179, ODO2_BOVIN
P57389, ODO2_BUCAI	Q8K9N2, ODO2_BUCAP	Q89AJ6, ODO2_BUCBP
P52993, ODO2_CUPNH	P83708, ODO2_DELAC	Q869Y7, ODO2_DICDI
P0AFG7, ODO2_ECO57	P0AFG6, ODO2_ECOLI	P45302, ODO2_HAEIN
P36957, ODO2_HUMAN	P86219, ODO2_MESAU	Q9D2G2, ODO2_MOUSE
Q9N0F1, ODO2_PIG	Q9I3D2, ODO2_PSEAE	P31051, ODO2_PSEPU
Q01205, ODO2_RAT	Q1RHI5, ODO2_RICBR	Q92J43, ODO2_RICCN
Q4UKI7, ODO2_RICFE	Q9ZDY4, ODO2_RICPR	Q68XI8, ODO2_RICTY
O94681, ODO2_SCHPO	P81896, ODO2_SOLTU	Q2FH26, ODO2_STAA3
Q2FYM2, ODO2_STAA8	Q2YY06, ODO2_STAAB	Q5HG07, ODO2_STAAC
Q99U75, ODO2_STAAM	Q7A5N4, ODO2_STAAN	Q6GGZ6, ODO2_STAAR
Q6G9E9, ODO2_STAAS	Q8NWR7, ODO2_STAAW	Q5HPC7, ODO2_STAEQ
Q8CSL9, ODO2_STAES	Q4L6C3, ODO2_STAHJ	Q49XM4, ODO2_STAS1
Q90512, ODO2_TAKRU	P19262, ODO2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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