ENZYME entry: EC 1.20.4.4

Accepted Name
Arsenate reductase (thioredoxin).
Reaction catalysed
Arsenate + thioredoxin <=> arsenite + thioredoxin disulfide + H(2)O
Comment(s)
  • The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin.
  • It has no activity with glutaredoxin (cf. EC 1.20.4.1).
  • Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds.
  • The enzyme also has the activity of EC 3.1.3.48.
Cross-references
BRENDA1.20.4.4
EC2PDB1.20.4.4
ExplorEnz1.20.4.4
PRIAM enzyme-specific profiles1.20.4.4
KEGG Ligand Database for Enzyme Nomenclature1.20.4.4
IUBMB Enzyme Nomenclature1.20.4.4
IntEnz1.20.4.4
MEDLINEFind literature relating to 1.20.4.4
MetaCyc1.20.4.4
UniProtKB/Swiss-Prot
Q74NT6, ARSC1_BACC1;  Q5HRI4, ARSC1_STAEQ;  Q4LAB5, ARSC1_STAHJ;  
Q49WS7, ARSC1_STAS1;  Q735E5, ARSC2_BACC1;  Q5HKB7, ARSC2_STAEQ;  
Q4LAA8, ARSC2_STAHJ;  Q49UH1, ARSC2_STAS1;  C3P101, ARSC_BACAA;  
C3LDK1, ARSC_BACAC;  Q81NJ6, ARSC_BACAN;  B7INE4, ARSC_BACC2;  
C1F0A7, ARSC_BACC3;  B7HWU2, ARSC_BACC7;  A7GP55, ARSC_BACCN;  
B9IRF0, ARSC_BACCQ;  Q81BK3, ARSC_BACCR;  Q639D2, ARSC_BACCZ;  
Q9K8K8, ARSC_BACHD;  Q6HGP0, ARSC_BACHK;  Q65IV4, ARSC_BACLD;  
Q8GJ74, ARSC_BACMD;  Q5WJS9, ARSC_BACSK;  P45947, ARSC_BACSU;  
C0ZEV2, ARSC_BREBN;  A4INR2, ARSC_GEOTN;  B9E7M5, ARSC_MACCJ;  
Q8ENQ5, ARSC_OCEIH;  Q2FFW6, ARSC_STAA3;  Q2FXF5, ARSC_STAA8;  
Q2YTL3, ARSC_STAAB;  Q5HF01, ARSC_STAAC;  A6QHV6, ARSC_STAAE;  
P0A005, ARSC_STAAN;  Q6GIZ3, ARSC_STAAR;  A8Z4K0, ARSC_STAAT;  
P0A006, ARSC_STAAU;  Q8CQF5, ARSC_STAES;  Q01257, ARSC_STAXY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.20.4.-
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