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ENZYME

ENZYME entry: EC 1.3.8.1

PURL: https://purl.expasy.org/enzyme/EC/1.3.8.1
Accepted Name
short-chain acyl-CoA dehydrogenase
Alternative Name(s)
butanoyl-CoA dehydrogenase
butyryl dehydrogenase
short-chain acyl CoA dehydrogenase
unsaturated acyl-CoA reductase
Reaction catalysed
a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms.
  • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
  • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
  • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA. cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.1 and EC 1.3.99.2.
Cross-references
BRENDA1.3.8.1
EC2PDB1.3.8.1
ExplorEnz1.3.8.1
KEGG Ligand Database for Enzyme Nomenclature1.3.8.1
IUBMB Enzyme Nomenclature1.3.8.1
MEDLINEFind literature relating to 1.3.8.1
MetaCyc1.3.8.1
Rhea expert-curated reactions1.3.8.1
UniProtKB/Swiss-Prot
Q3ZBF6, ACADS_BOVINP16219, ACADS_HUMANQ07417, ACADS_MOUSE
P79273, ACADS_PIGQ5RAS0, ACADS_PONABP15651, ACADS_RAT
Q5EAD4, ACDSB_BOVINP45954, ACDSB_HUMANQ9DBL1, ACDSB_MOUSE
Q5RF40, ACDSB_PONABP70584, ACDSB_RATP52042, ACDS_CLOAB
Q06319, ACDS_MEGELQ0AVM4, BCD1_SYNWWQ0AVA8, BCD2_SYNWW
Q3L887, FADE5_MYCS2O53666, FADE5_MYCTUQ3SZI8, IVD_BOVIN
P26440, IVD_HUMANQ9JHI5, IVD_MOUSEQ5RBD5, IVD_PONAB
P12007, IVD_RAT

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