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ENZYME entry: EC 1.3.8.1
| Accepted Name |
|---|
| short-chain acyl-CoA dehydrogenase.
|
| Alternative Name(s) |
|---|
| butanoyl-CoA dehydrogenase. |
| butyryl dehydrogenase. |
| short-chain acyl CoA dehydrogenase. |
| unsaturated acyl-CoA reductase. |
| Reaction catalysed |
|---|
| a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] |
| Comment(s) |
|---|
- One of several enzymes that catalyze the first step in fatty acids
beta-oxidation.
- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA
thioesters to give a trans 2,3-unsaturated product by removal of the
two pro-R hydrogen atoms.
- The enzyme from beef liver accepts substrates with acyl chain lengths
of 3 to 8 carbon atoms.
- The highest activity was reported with either butanoyl-CoA or
pentanoyl-CoA.
- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared
to butanoyl-CoA) and no activity with octanoyl-CoA. cf. EC 1.3.8.7,
EC 1.3.8.8 and EC 1.3.8.9.
- Formerly EC 1.3.2.1 and EC 1.3.99.2.
|
| Cross-references |
|---|
| BRENDA | 1.3.8.1 |
| EC2PDB | 1.3.8.1 |
| ExplorEnz | 1.3.8.1 |
| PRIAM enzyme-specific profiles | 1.3.8.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.8.1 |
| IUBMB Enzyme Nomenclature | 1.3.8.1 |
| IntEnz | 1.3.8.1 |
| MEDLINE | Find literature relating to 1.3.8.1 |
| MetaCyc | 1.3.8.1 |
| Rhea expert-curated reactions | 1.3.8.1 |
| UniProtKB/Swiss-Prot |
| Q3ZBF6, ACADS_BOVIN; | P16219, ACADS_HUMAN; | Q07417, ACADS_MOUSE; |
| P79273, ACADS_PIG; | Q5RAS0, ACADS_PONAB; | P15651, ACADS_RAT; |
| P52042, ACDS_CLOAB; | Q06319, ACDS_MEGEL; | Q0AVM4, BCD1_SYNWW; |
| Q0AVA8, BCD2_SYNWW; | Q3L887, FADE5_MYCS2; | O53666, FADE5_MYCTU; |
| Q3SZI8, IVD_BOVIN; | P26440, IVD_HUMAN; | Q9JHI5, IVD_MOUSE; |
| Q5RBD5, IVD_PONAB; | P12007, IVD_RAT; |
|
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All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.3.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-