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ENZYME entry: EC 1.3.8.1
Accepted Name |
short-chain acyl-CoA dehydrogenase.
|
Alternative Name(s) |
butanoyl-CoA dehydrogenase. |
butyryl dehydrogenase. |
short-chain acyl CoA dehydrogenase. |
unsaturated acyl-CoA reductase. |
Reaction catalysed |
a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] |
Comment(s) |
- One of several enzymes that catalyze the first step in fatty acids
beta-oxidation.
- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA
thioesters to give a trans 2,3-unsaturated product by removal of the
two pro-R hydrogen atoms.
- The enzyme from beef liver accepts substrates with acyl chain lengths
of 3 to 8 carbon atoms.
- The highest activity was reported with either butanoyl-CoA or
pentanoyl-CoA.
- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared
to butanoyl-CoA) and no activity with octanoyl-CoA. cf. EC 1.3.8.7,
EC 1.3.8.8 and EC 1.3.8.9.
- Formerly EC 1.3.2.1 and EC 1.3.99.2.
|
Cross-references |
BRENDA | 1.3.8.1 |
EC2PDB | 1.3.8.1 |
ExplorEnz | 1.3.8.1 |
PRIAM enzyme-specific profiles | 1.3.8.1 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.8.1 |
IUBMB Enzyme Nomenclature | 1.3.8.1 |
IntEnz | 1.3.8.1 |
MEDLINE | Find literature relating to 1.3.8.1 |
MetaCyc | 1.3.8.1 |
Rhea expert-curated reactions | 1.3.8.1 |
UniProtKB/Swiss-Prot |
Q3ZBF6, ACADS_BOVIN; | P16219, ACADS_HUMAN; | Q07417, ACADS_MOUSE; |
P79273, ACADS_PIG; | Q5RAS0, ACADS_PONAB; | P15651, ACADS_RAT; |
P52042, ACDS_CLOAB; | Q06319, ACDS_MEGEL; | Q0AVM4, BCD1_SYNWW; |
Q0AVA8, BCD2_SYNWW; | Q3L887, FADE5_MYCS2; | O53666, FADE5_MYCTU; |
Q3SZI8, IVD_BOVIN; | P26440, IVD_HUMAN; | Q9JHI5, IVD_MOUSE; |
Q5RBD5, IVD_PONAB; | P12007, IVD_RAT; |
|
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All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.3.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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