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ENZYME entry: EC 1.3.8.1

Accepted Name
Short-chain acyl-CoA dehydrogenase.
Alternative Name(s)
Butanoyl-CoA dehydrogenase.
Butyryl dehydrogenase.
Short-chain acyl CoA dehydrogenase.
Unsaturated acyl-CoA reductase.
Reaction catalysed
A short-chain acyl-CoA + electron-transfer flavoprotein <=> a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Cofactor(s)
FAD.
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms.
  • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
  • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
  • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA.
  • Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.1 and EC 1.3.99.2.
Cross-references
PROSITEPDOC00070
BRENDA1.3.8.1
EC2PDB1.3.8.1
ExplorEnz1.3.8.1
PRIAM enzyme-specific profiles1.3.8.1
KEGG Ligand Database for Enzyme Nomenclature1.3.8.1
IUBMB Enzyme Nomenclature1.3.8.1
IntEnz1.3.8.1
MEDLINEFind literature relating to 1.3.8.1
MetaCyc1.3.8.1
Rhea expert-curated reactions1.3.8.1
UniProtKB/Swiss-Prot
Q3ZBF6, ACADS_BOVIN;  P16219, ACADS_HUMAN;  Q07417, ACADS_MOUSE;  
P79273, ACADS_PIG;  Q5RAS0, ACADS_PONAB;  P15651, ACADS_RAT;  
P52042, ACDS_CLOAB;  Q06319, ACDS_MEGEL;  Q0AVM4, BCD1_SYNWW;  
Q0AVA8, BCD2_SYNWW;  Q3L887, FADE5_MYCS2;  O53666, FADE5_MYCTU;  
Q3SZI8, IVD_BOVIN;  P26440, IVD_HUMAN;  Q9JHI5, IVD_MOUSE;  
Q5RBD5, IVD_PONAB;  P12007, IVD_RAT;  

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