ENZYME entry: EC 1.3.8.1
Accepted Name |
Short-chain acyl-CoA dehydrogenase.
|
Alternative Name(s) |
Butanoyl-CoA dehydrogenase. |
Butyryl dehydrogenase. |
Short-chain acyl CoA dehydrogenase. |
Unsaturated acyl-CoA reductase. |
Reaction catalysed |
A short-chain acyl-CoA + electron-transfer flavoprotein <=> a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein |
Cofactor(s) |
FAD.
|
Comment(s) |
- One of several enzymes that catalyze the first step in fatty acids
beta-oxidation.
- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA
thioesters to give a trans 2,3-unsaturated product by removal of the
two pro-R hydrogen atoms.
- The enzyme from beef liver accepts substrates with acyl chain lengths
of 3 to 8 carbon atoms.
- The highest activity was reported with either butanoyl-CoA or
pentanoyl-CoA.
- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared
to butanoyl-CoA) and no activity with octanoyl-CoA.
- Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
- Formerly EC 1.3.2.1 and EC 1.3.99.2.
|
Cross-references |
PROSITE | PDOC00070 |
BRENDA | 1.3.8.1 |
EC2PDB | 1.3.8.1 |
ExplorEnz | 1.3.8.1 |
PRIAM enzyme-specific profiles | 1.3.8.1 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.8.1 |
IUBMB Enzyme Nomenclature | 1.3.8.1 |
IntEnz | 1.3.8.1 |
MEDLINE | Find literature relating to 1.3.8.1 |
MetaCyc | 1.3.8.1 |
UniProtKB/Swiss-Prot |
Q3ZBF6, ACADS_BOVIN; | P16219, ACADS_HUMAN; | Q07417, ACADS_MOUSE; |
P79273, ACADS_PIG; | Q5RAS0, ACADS_PONAB; | P15651, ACADS_RAT; |
P52042, ACDS_CLOAB; | Q06319, ACDS_MEGEL; | Q0AVM4, BCD1_SYNWW; |
Q0AVA8, BCD2_SYNWW; |
|
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