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ENZYME

ENZYME entry: EC 1.3.8.8

Accepted Name
long-chain-acyl-CoA dehydrogenase
Reaction catalysed
a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms.
  • The highest activity was found with C12, and the rates with C8 and C16 were 80% and 70%, respectively.
  • The enzyme from rat can accept substrates with C8-C22.
  • It is most active with C14 and C16, and has no activity with C4, C6 or C24. cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.99.3 and EC 1.3.99.13.
Cross-references
BRENDA1.3.8.8
EC2PDB1.3.8.8
ExplorEnz1.3.8.8
PRIAM enzyme-specific profiles1.3.8.8
KEGG Ligand Database for Enzyme Nomenclature1.3.8.8
IUBMB Enzyme Nomenclature1.3.8.8
IntEnz1.3.8.8
MEDLINEFind literature relating to 1.3.8.8
MetaCyc1.3.8.8
Rhea expert-curated reactions1.3.8.8
UniProtKB/Swiss-Prot
P28330, ACADL_HUMANQ60HI0, ACADL_MACFAP51174, ACADL_MOUSE
P79274, ACADL_PIGP15650, ACADL_RATQ3L887, FADE5_MYCS2
O53666, FADE5_MYCTUQ8X7R2, FADE_ECO57Q47146, FADE_ECOLI
Q8Z937, FADE_SALTIQ8ZRJ7, FADE_SALTYQ8ZBY6, FADE_YERPE

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