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ENZYME

ENZYME entry: EC 1.3.8.7

Accepted Name
medium-chain acyl-CoA dehydrogenase
Alternative Name(s)
acyl CoA dehydrogenase
acyl coenzyme A dehydrogenase
acyl dehydrogenase
fatty-acyl-CoA dehydrogenase
fatty acyl coenzyme A dehydrogenase
general acyl CoA dehydrogenase
Reaction catalysed
a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds.
  • The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds. cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.2 and EC 1.3.99.3.
Cross-references
BRENDA1.3.8.7
EC2PDB1.3.8.7
ExplorEnz1.3.8.7
PRIAM enzyme-specific profiles1.3.8.7
KEGG Ligand Database for Enzyme Nomenclature1.3.8.7
IUBMB Enzyme Nomenclature1.3.8.7
IntEnz1.3.8.7
MEDLINEFind literature relating to 1.3.8.7
MetaCyc1.3.8.7
Rhea expert-curated reactions1.3.8.7
UniProtKB/Swiss-Prot
A8XNF0, ACAD1_CAEBRA8WP91, ACAD2_CAEBRQ3SZB4, ACADM_BOVIN
Q22347, ACADM_CAEELQ9VSA3, ACADM_DROMEP11310, ACADM_HUMAN
Q8HXY8, ACADM_MACFAP45952, ACADM_MOUSEA5A6I0, ACADM_PANTR
P41367, ACADM_PIGP08503, ACADM_RATQ3L887, FADE5_MYCS2
O53666, FADE5_MYCTUQ8X7R2, FADE_ECO57Q47146, FADE_ECOLI
Q8Z937, FADE_SALTIQ8ZRJ7, FADE_SALTYQ8ZBY6, FADE_YERPE

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