Home  |  Contact

ENZYME entry: EC 1.3.8.7

Accepted Name
medium-chain acyl-CoA dehydrogenase.
Alternative Name(s)
acyl CoA dehydrogenase.
acyl coenzyme A dehydrogenase.
acyl dehydrogenase.
fatty-acyl-CoA dehydrogenase.
fatty acyl coenzyme A dehydrogenase.
general acyl CoA dehydrogenase.
Reaction catalysed
a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds.
  • The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds.
  • cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.2 and EC 1.3.99.3.
Cross-references
BRENDA1.3.8.7
EC2PDB1.3.8.7
ExplorEnz1.3.8.7
PRIAM enzyme-specific profiles1.3.8.7
KEGG Ligand Database for Enzyme Nomenclature1.3.8.7
IUBMB Enzyme Nomenclature1.3.8.7
IntEnz1.3.8.7
MEDLINEFind literature relating to 1.3.8.7
MetaCyc1.3.8.7
Rhea expert-curated reactions1.3.8.7
UniProtKB/Swiss-Prot
A8XNF0, ACAD1_CAEBR;  A8WP91, ACAD2_CAEBR;  Q3SZB4, ACADM_BOVIN;  
Q22347, ACADM_CAEEL;  Q9VSA3, ACADM_DROME;  P11310, ACADM_HUMAN;  
Q8HXY8, ACADM_MACFA;  P45952, ACADM_MOUSE;  A5A6I0, ACADM_PANTR;  
P41367, ACADM_PIG;  P08503, ACADM_RAT;  Q3L887, FADE5_MYCS2;  
O53666, FADE5_MYCTU;  Q8X7R2, FADE_ECO57;  Q47146, FADE_ECOLI;  
Q8Z937, FADE_SALTI;  Q8ZRJ7, FADE_SALTY;  Q8ZBY6, FADE_YERPE;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-