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ENZYME

ENZYME entry: EC 1.3.8.7

PURL: https://purl.expasy.org/enzyme/EC/1.3.8.7
Accepted Name
medium-chain acyl-CoA dehydrogenase
Alternative Name(s)
acyl CoA dehydrogenase
acyl coenzyme A dehydrogenase
acyl dehydrogenase
fatty-acyl-CoA dehydrogenase
fatty acyl coenzyme A dehydrogenase
general acyl CoA dehydrogenase
Reaction catalysed
a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds.
  • The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds. cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.2 and EC 1.3.99.3.
Cross-references
BRENDA1.3.8.7
EC2PDB1.3.8.7
ExplorEnz1.3.8.7
KEGG Ligand Database for Enzyme Nomenclature1.3.8.7
IUBMB Enzyme Nomenclature1.3.8.7
MEDLINEFind literature relating to 1.3.8.7
MetaCyc1.3.8.7
Rhea expert-curated reactions1.3.8.7
UniProtKB/Swiss-Prot
A8XNF0, ACAD1_CAEBRA8WP91, ACAD2_CAEBRQ9H845, ACAD9_HUMAN
Q8JZN5, ACAD9_MOUSEB1WC61, ACAD9_RATP28330, ACADL_HUMAN
Q60HI0, ACADL_MACFAP51174, ACADL_MOUSEP79274, ACADL_PIG
P15650, ACADL_RATQ3SZB4, ACADM_BOVINQ22347, ACADM_CAEEL
Q9VSA3, ACADM_DROMEP11310, ACADM_HUMANQ8HXY8, ACADM_MACFA
P45952, ACADM_MOUSEA5A6I0, ACADM_PANTRP41367, ACADM_PIG
P08503, ACADM_RATQ3L887, FADE5_MYCS2O53666, FADE5_MYCTU
Q8X7R2, FADE_ECO57Q47146, FADE_ECOLIQ8Z937, FADE_SALTI
Q8ZRJ7, FADE_SALTYQ8ZBY6, FADE_YERPE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-