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ENZYME entry: EC 1.3.8.9

Accepted Name
Very-long-chain acyl-CoA dehydrogenase.
Reaction catalysed
A very-long-chain acyl-CoA + electron-transfer flavoprotein <=> a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Cofactor(s)
FAD.
Comment(s)
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme is most active toward long-chain acyl-CoAs such as C(14), C(16) and C(18), but is also active with very-long-chain acyl-CoAs up to 24 carbons.
  • It shows no activity for substrates of less than 12 carbons.
  • It's specific activity toward palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase.
  • cf. EC 1.3.8.1, EC 1.3.8.7 and EC 1.3.8.8.
  • Formerly EC 1.3.99.3.
Cross-references
BRENDA1.3.8.9
EC2PDB1.3.8.9
ExplorEnz1.3.8.9
PRIAM enzyme-specific profiles1.3.8.9
KEGG Ligand Database for Enzyme Nomenclature1.3.8.9
IUBMB Enzyme Nomenclature1.3.8.9
IntEnz1.3.8.9
MEDLINEFind literature relating to 1.3.8.9
MetaCyc1.3.8.9
Rhea expert-curated reactions1.3.8.9
UniProtKB/Swiss-Prot
P48818, ACADV_BOVIN;  P49748, ACADV_HUMAN;  Q8HXY7, ACADV_MACFA;  
P50544, ACADV_MOUSE;  P45953, ACADV_RAT;  

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