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ENZYME

ENZYME entry: EC 1.5.1.54

PURL: https://purl.expasy.org/enzyme/EC/1.5.1.54
Accepted Name
methylenetetrahydrofolate reductase (NADH)
Alternative Name(s)
5,10-CH2-H4folate reductase
5,10-methylenetetrahydrofolate reductase
5,10-methylenetetrahydrofolate reductase (FADH2)
N(5),10-methylenetetrahydrofolate reductase
Reaction catalysed
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H(+)
Comment(s)
  • A flavoprotein (FAD).
  • The enzyme, found in plants and some bacteria, catalyzes the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADH as the electron donor.
  • It play an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis.
  • These proteins either contain a C-terminal domain that does not mediate allosteric regulation (as in plants) or lack this domain entirely (as in Escherichia coli).
  • As a result, the plant enzymes are not inhibited by S-adenosyl-L- methionine, unlike other eukaryotic enzymes, and catalyze a reversible reaction. cf. EC 1.5.1.53, EC 1.5.1.20, and EC 1.5.7.1.
Cross-references
BRENDA1.5.1.54
EC2PDB1.5.1.54
ExplorEnz1.5.1.54
KEGG Ligand Database for Enzyme Nomenclature1.5.1.54
IUBMB Enzyme Nomenclature1.5.1.54
MEDLINEFind literature relating to 1.5.1.54
MetaCyc1.5.1.54
Rhea expert-curated reactions1.5.1.54
UniProtKB/Swiss-Prot
O67422, METF_AQUAEP57154, METF_BUCAIQ8KA62, METF_BUCAP
Q89B13, METF_BUCBPP0AEZ1, METF_ECOLIP45208, METF_HAEIN
Q9JZQ3, METF_NEIMBP71319, METF_PECCCP11003, METF_SALTY
P0AEZ2, METF_SHIFLG2IQS8, METF_SPHSKO54235, METF_STRLI
Q9SE60, MTHR1_ARATHQ9SE94, MTHR1_MAIZEO80585, MTHR2_ARATH
Q75HE6, MTHR_ORYSJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
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