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ENZYME entry: EC 1.5.3.16

Accepted Name
Spermine oxidase.
Alternative Name(s)
SMO.
Reaction catalysed
Spermine + O(2) + H(2)O <=> spermidine + 3-aminopropanal + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency.
  • The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyzes the oxidation of spermine at the exo (three-carbon) side of the tertiary amine.
  • No activity with spermidine.
  • Weak activity with N(1)-acetylspermine.
  • Differs in specificity from EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15 and EC 1.5.3.17.
  • Formerly EC 1.5.3.11, EC 1.5.3.n1, EC 1.5.3.n2, EC 1.5.3.n3 and EC 1.5.3.n5.
Cross-references
BRENDA1.5.3.16
EC2PDB1.5.3.16
ExplorEnz1.5.3.16
PRIAM enzyme-specific profiles1.5.3.16
KEGG Ligand Database for Enzyme Nomenclature1.5.3.16
IUBMB Enzyme Nomenclature1.5.3.16
IntEnz1.5.3.16
MEDLINEFind literature relating to 1.5.3.16
MetaCyc1.5.3.16
Rhea expert-curated reactions1.5.3.16
UniProtKB/Swiss-Prot
Q9FNA2, PAO1_ARATH;  Q8H191, PAO4_ARATH;  Q9NWM0, SMOX_HUMAN;  
Q99K82, SMOX_MOUSE;  

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