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ENZYME

ENZYME entry: EC 1.5.3.16

PURL: https://purl.expasy.org/enzyme/EC/1.5.3.16
Accepted Name
spermine oxidase
Alternative Name(s)
SMO
Reaction catalysed
spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
Comment(s)
  • The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency.
  • The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyzes the oxidation of spermine at the exo (three-carbon) side of the tertiary amine.
  • No activity with spermidine.
  • Weak activity with N(1)-acetylspermine.
  • Differs in specificity from EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15 and EC 1.5.3.17.
  • Formerly EC 1.5.3.11, EC 1.5.3.n1, EC 1.5.3.n2, EC 1.5.3.n3 and EC 1.5.3.n5.
Cross-references
BRENDA1.5.3.16
EC2PDB1.5.3.16
ExplorEnz1.5.3.16
KEGG Ligand Database for Enzyme Nomenclature1.5.3.16
IUBMB Enzyme Nomenclature1.5.3.16
MEDLINEFind literature relating to 1.5.3.16
MetaCyc1.5.3.16
Rhea expert-curated reactions1.5.3.16
UniProtKB/Swiss-Prot
Q9FNA2, PAO1_ARATHQ8H191, PAO4_ARATHQ9NWM0, SMOX_HUMAN
Q99K82, SMOX_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
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