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ENZYME

ENZYME entry: EC 1.5.3.13

Accepted Name
N(1)-acetylpolyamine oxidase
Alternative Name(s)
PAO
polyamine oxidase
Reaction catalysed
  • H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine
  • H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine
Comment(s)
  • The enzyme also catalyzes the reaction: N(1),N(12)-diacetylspermine + O2 + H2O = N(1)-acetylspermidine + 3-acetamamidopropanal + H2O2.
  • No or very weak activity with spermine, or spermidine in absence of aldehydes.
  • In presence of aldehydes the enzyme catalyzes the reactions: 1.
  • spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2.
  • spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2.
  • Found in mammalian peroxisomes and oxidizes N(1)-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal.
  • Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion.
  • Differs in specificity from EC 1.5.3.14, EC 1.5.3.15, EC 1.5.3.16 and EC 1.5.3.17.
  • Formerly EC 1.5.3.11, EC 1.5.3.n3, EC 1.5.3.n4 and EC 1.5.3.n10.
Cross-references
BRENDA1.5.3.13
EC2PDB1.5.3.13
ExplorEnz1.5.3.13
PRIAM enzyme-specific profiles1.5.3.13
KEGG Ligand Database for Enzyme Nomenclature1.5.3.13
IUBMB Enzyme Nomenclature1.5.3.13
IntEnz1.5.3.13
MEDLINEFind literature relating to 1.5.3.13
MetaCyc1.5.3.13
Rhea expert-curated reactions1.5.3.13
UniProtKB/Swiss-Prot
Q865R1, PAOX_BOVINQ6QHF9, PAOX_HUMANQ8C0L6, PAOX_MOUSE

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