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ENZYME entry: EC

Accepted Name
N(1)-acetylpolyamine oxidase.
Alternative Name(s)
polyamine oxidase.
Reaction catalysed
  • H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine
  • H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine
  • The enzyme also catalyzes the reaction: N(1),N(12)-diacetylspermine + O2 + H2O = N(1)-acetylspermidine + 3-acetamamidopropanal + H2O2.
  • No or very weak activity with spermine, or spermidine in absence of aldehydes.
  • In presence of aldehydes the enzyme catalyzes the reactions: 1.
  • spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2.
  • spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2.
  • Found in mammalian peroxisomes and oxidizes N(1)-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal.
  • Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion.
  • Differs in specificity from EC, EC, EC and EC
  • Formerly EC, EC 1.5.3.n3, EC 1.5.3.n4 and EC 1.5.3.n10.
PRIAM enzyme-specific profiles1.5.3.13
KEGG Ligand Database for Enzyme Nomenclature1.5.3.13
IUBMB Enzyme Nomenclature1.5.3.13
MEDLINEFind literature relating to
Rhea expert-curated reactions1.5.3.13

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-