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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.5.3.13

Accepted Name
N(1)-acetylpolyamine oxidase.
Alternative Name(s)
PAO.
Polyamine oxidase.
Reaction catalysed
  • N(1)-acetylspermidine + O(2) + H(2)O <=> putrescine + 3-acetamidopropanal + H(2)O(2)
  • N(1)-acetylspermine + O(2) + H(2)O <=> spermidine + 3-acetamidopropanal + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • The enzyme also catalyzes the reaction: N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamamidopropanal + H(2)O(2).
  • No or very weak activity with spermine, or spermidine in absence of aldehydes.
  • In presence of aldehydes the enzyme catalyzes the reactions: 1.
  • spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2), and with weak efficiency 2.
  • spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).
  • Found in mammalian peroxisomes and oxidizes N(1)-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal.
  • Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion.
  • Differs in specificity from EC 1.5.3.14, EC 1.5.3.15, EC 1.5.3.16 and EC 1.5.3.17.
  • Formerly EC 1.5.3.11, EC 1.5.3.n3, EC 1.5.3.n4 and EC 1.5.3.n10.
Cross-references
BRENDA1.5.3.13
EC2PDB1.5.3.13
ExplorEnz1.5.3.13
PRIAM enzyme-specific profiles1.5.3.13
KEGG Ligand Database for Enzyme Nomenclature1.5.3.13
IUBMB Enzyme Nomenclature1.5.3.13
IntEnz1.5.3.13
MEDLINEFind literature relating to 1.5.3.13
MetaCyc1.5.3.13
UniProtKB/Swiss-Prot
Q865R1, PAOX_BOVIN;  Q6QHF9, PAOX_HUMAN;  Q8C0L6, PAOX_MOUSE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-