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ENZYME

ENZYME entry: EC 1.5.3.17

Accepted Name
non-specific polyamine oxidase
Alternative Name(s)
polyamine oxidase
Reaction catalysed
  • H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine
  • H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine
  • H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine
  • H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine
Comment(s)
  • The non-specific polyamine oxidases may differ from each other considerably.
  • The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N(8)-acetylspermidine.
  • The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine.
  • The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines.
  • The specific polyamine oxidases are classified as EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15 and EC 1.5.3.16.
  • Formerly EC 1.5.3.11.
Cross-references
BRENDA1.5.3.17
EC2PDB1.5.3.17
ExplorEnz1.5.3.17
PRIAM enzyme-specific profiles1.5.3.17
KEGG Ligand Database for Enzyme Nomenclature1.5.3.17
IUBMB Enzyme Nomenclature1.5.3.17
IntEnz1.5.3.17
MEDLINEFind literature relating to 1.5.3.17
MetaCyc1.5.3.17
Rhea expert-curated reactions1.5.3.17
UniProtKB/Swiss-Prot
P50264, FMS1_YEASTQ9FNA2, PAO1_ARATHQ9LYT1, PAO3_ARATH

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