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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Non-specific polyamine oxidase.
Alternative Name(s)
Polyamine oxidase.
Reaction catalysed
  • Spermine + O(2) + H(2)O <=> spermidine + 3-aminopropanal + H(2)O(2)
  • Spermidine + O(2) + H(2)O <=> putrescine + 3-aminopropanal + H(2)O(2)
  • N(1)-acetylspermine + O(2) + H(2)O <=> spermidine + 3-acetamidopropanal + H(2)O(2)
  • N(1)-acetylspermidine + O(2) + H(2)O <=> putrescine + 3-acetamidopropanal + H(2)O(2)
  • The non-specific polyamine oxidases may differ from each other considerably.
  • The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N(8)-acetylspermidine.
  • The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine.
  • The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines.
  • The specific polyamine oxidases are classified as EC, EC, EC and EC
  • Formerly EC, EC 1.5.3.n1, EC 1.5.3.n2 and EC 1.5.3.n4.
PRIAM enzyme-specific profiles1.5.3.17
KEGG Ligand Database for Enzyme Nomenclature1.5.3.17
IUBMB Enzyme Nomenclature1.5.3.17
MEDLINEFind literature relating to

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-