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ENZYME

ENZYME entry: EC 2.1.1.113

Accepted Name
site-specific DNA-methyltransferase (cytosine-N(4)-specific)
Alternative Name(s)
modification methylase
N(4)-cytosine-specific DNA methylase
restriction-modification system
Reaction catalysed
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • This is a large group of enzymes, the majority of which, with enzymes of similar site specificity listed as EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5, form so-called restriction-modification systems.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
Cross-references
BRENDA2.1.1.113
EC2PDB2.1.1.113
ExplorEnz2.1.1.113
PRIAM enzyme-specific profiles2.1.1.113
KEGG Ligand Database for Enzyme Nomenclature2.1.1.113
IUBMB Enzyme Nomenclature2.1.1.113
IntEnz2.1.1.113
MEDLINEFind literature relating to 2.1.1.113
MetaCyc2.1.1.113
Rhea expert-curated reactions2.1.1.113
UniProtKB/Swiss-Prot
P0A462, MTA1_ANAVAP0A461, MTA1_NOSS1P23941, MTB1_BACAM
O68556, MTB1_BACIUQ9LAI2, MTB1_BACSQP70986, MTB1_GEOSE
P18051, MTB2_BACAMQ45489, MTB2_BACIUQ04845, MTC1_CITFR
P14243, MTC9_CITFRP29568, MTHZ_METTFQ58392, MTM1_METJA
Q58843, MTM2_METJAQ58893, MTM5_METJAQ58606, MTM6_METJA
P14244, MTMV_KOCVAO59647, MTMW_METWOP11409, MTP2_PROHU
O52692, MTS1_STRCSO52513, MTS1_STRFIP14230, MTSM_SERMA
P30774, MTX1_XANCC

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