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ENZYME entry: EC

Accepted Name
[Histone H3]-lysine(27) N-trimethyltransferase.
Reaction catalysed
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27)
  • This entry describes enzymes that successively methylate the L-lysine(27) residue of histone H3 (H3K27), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • The methylation of lysine(27) leads to transcriptional repression of the affected target genes.
  • The enzyme associates with other proteins to form a complex that is essential for activity.
  • The enzyme can also methylate some non-histone proteins.
  • Formerly EC
PRIAM enzyme-specific profiles2.1.1.356
KEGG Ligand Database for Enzyme Nomenclature2.1.1.356
IUBMB Enzyme Nomenclature2.1.1.356
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