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ENZYME

ENZYME entry: EC 2.1.1.356

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.356
Accepted Name
[histone H3]-lysine(27) N-trimethyltransferase
Reaction catalysed
L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • This entry describes enzymes that successively methylate the L-lysine(27) residue of histone H3 (H3K27), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • The methylation of lysine(27) leads to transcriptional repression of the affected target genes.
  • The enzyme associates with other proteins to form a complex that is essential for activity.
  • The enzyme can also methylate some non-histone proteins. cf. EC 2.1.1.369 and EC 2.1.1.371.
Cross-references
BRENDA2.1.1.356
EC2PDB2.1.1.356
ExplorEnz2.1.1.356
KEGG Ligand Database for Enzyme Nomenclature2.1.1.356
IUBMB Enzyme Nomenclature2.1.1.356
MEDLINEFind literature relating to 2.1.1.356
MetaCyc2.1.1.356
Rhea expert-curated reactions2.1.1.356
UniProtKB/Swiss-Prot
Q5VN06, CLF_ORYSJQ8S4P6, EZ1_MAIZEQ84UI6, EZ1_ORYSI
Q10MI4, EZ1_ORYSJQ8S4P5, EZ2_MAIZEQ8S4P4, EZ3_MAIZE
Q9ZSM8, EZA1_ARATHA7E2Z2, EZH1_BOVINQ92800, EZH1_HUMAN
P70351, EZH1_MOUSEQ5RDS6, EZH1_PONABQ98SM3, EZH2A_XENLA
Q4V863, EZH2B_XENLAG0SDW4, EZH2_CHATDQ08BS4, EZH2_DANRE
Q15910, EZH2_HUMANQ4R381, EZH2_MACFAQ61188, EZH2_MOUSE
Q28D84, EZH2_XENTRP42124, EZ_DROMEO65312, MEDEA_ARATH
O17514, MES2_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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