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ENZYME entry: EC 2.1.1.371

Accepted Name
[Histone H3]-lysine(27) N-dimethyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) <=> 2 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27)
Comment(s)
  • This entry describes enzymes that successively methylate the L-lysine(27) residue of histone H3 (H3K27) twice, ultimately generating a dimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • The human NSD3 protein also catalyzes the activity of EC 2.1.1.370.
  • Cf. EC 2.1.1.369 and EC 2.1.1.356.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.371
EC2PDB2.1.1.371
ExplorEnz2.1.1.371
PRIAM enzyme-specific profiles2.1.1.371
KEGG Ligand Database for Enzyme Nomenclature2.1.1.371
IUBMB Enzyme Nomenclature2.1.1.371
IntEnz2.1.1.371
MEDLINEFind literature relating to 2.1.1.371
MetaCyc2.1.1.371
Rhea expert-curated reactions2.1.1.371
UniProtKB/Swiss-Prot
Q9BZ95, NSD3_HUMAN;  Q6P2L6, NSD3_MOUSE;  

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