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ENZYME entry: EC 2.1.1.369

Accepted Name
[Histone H3]-lysine(27) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) <=> S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Comment(s)
  • This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form.
  • This modification influences the binding of chromatin-associated proteins.
  • The methylation of lysine-27 leads to transcriptional repression of the affected target genes.
  • Cf. EC 2.1.1.371 and EC 2.1.1.356.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.369
EC2PDB2.1.1.369
ExplorEnz2.1.1.369
PRIAM enzyme-specific profiles2.1.1.369
KEGG Ligand Database for Enzyme Nomenclature2.1.1.369
IUBMB Enzyme Nomenclature2.1.1.369
IntEnz2.1.1.369
MEDLINEFind literature relating to 2.1.1.369
MetaCyc2.1.1.369
Rhea expert-curated reactions2.1.1.369
UniProtKB/Swiss-Prot
Q8VZJ1, ATXR5_ARATH;  B9RU15, ATXR5_RICCO;  

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