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ENZYME

ENZYME entry: EC 2.1.1.369

Accepted Name
[histone H3]-lysine(27) N-methyltransferase
Reaction catalysed
L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form.
  • This modification influences the binding of chromatin-associated proteins.
  • The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.356 and EC 2.1.1.371.
Cross-references
BRENDA2.1.1.369
EC2PDB2.1.1.369
ExplorEnz2.1.1.369
PRIAM enzyme-specific profiles2.1.1.369
KEGG Ligand Database for Enzyme Nomenclature2.1.1.369
IUBMB Enzyme Nomenclature2.1.1.369
IntEnz2.1.1.369
MEDLINEFind literature relating to 2.1.1.369
MetaCyc2.1.1.369
Rhea expert-curated reactions2.1.1.369
UniProtKB/Swiss-Prot
Q8VZJ1, ATXR5_ARATHB9RU15, ATXR5_RICCOQ9FNE9, ATXR6_ARATH
Q93YF5, SUVH1_TOBAC

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