ENZYME entry: EC 2.1.1.357
| Accepted Name |
|---|
| [Histone H3]-lysine(36) N-dimethyltransferase.
|
| Reaction catalysed |
|---|
| 2 S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) <=> 2 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) |
| Comment(s) |
|---|
- This entry describes a group of metazoan enzymes that catalyze two
successive methylations of lysine(36) of histone H3 (H3K36), forming
mono- and dimethylated forms.
- These modifications influence the binding of chromatin-associated
proteins.
- The product can be further methylated to the trimethyl form by
EC 2.1.1.358.
- The yeast SET2 enzyme can catalyze all three methylations (see
EC 2.1.1.359).
- Formerly EC 2.1.1.34.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.357 |
| EC2PDB | 2.1.1.357 |
| ExplorEnz | 2.1.1.357 |
| PRIAM enzyme-specific profiles | 2.1.1.357 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.357 |
| IUBMB Enzyme Nomenclature | 2.1.1.357 |
| IntEnz | 2.1.1.357 |
| MEDLINE | Find literature relating to 2.1.1.357 |
| MetaCyc | 2.1.1.357 |
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