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ENZYME entry: EC 2.1.1.357

Accepted Name
[histone H3]-lysine(36) N-dimethyltransferase.
Reaction catalysed
L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes a group of metazoan enzymes that catalyze two successive methylations of lysine(36) of histone H3 (H3K36), forming mono- and dimethylated forms.
  • These modifications influence the binding of chromatin-associated proteins.
  • The product can be further methylated to the trimethyl form by EC 2.1.1.358.
  • The yeast SET2 enzyme can catalyze all three methylations (see EC 2.1.1.359).
Cross-references
BRENDA2.1.1.357
EC2PDB2.1.1.357
ExplorEnz2.1.1.357
PRIAM enzyme-specific profiles2.1.1.357
KEGG Ligand Database for Enzyme Nomenclature2.1.1.357
IUBMB Enzyme Nomenclature2.1.1.357
IntEnz2.1.1.357
MEDLINEFind literature relating to 2.1.1.357
MetaCyc2.1.1.357
Rhea expert-curated reactions2.1.1.357
UniProtKB/Swiss-Prot
F4K1J4, ATXR7_ARATH;  Q9NH52, MES4_CAEEL;  Q8MT36, MES4_DROME;  
Q96L73, NSD1_HUMAN;  O88491, NSD1_MOUSE;  O96028, NSD2_HUMAN;  
Q8BVE8, NSD2_MOUSE;  Q0VD24, SETMR_BOVIN;  Q53H47, SETMR_HUMAN;  
Q80UJ9, SETMR_MOUSE;  Q5I0M0, SETMR_RAT;  Q8I4F7, SMYDL_CAEEL;  

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