Home  |  Contact

ENZYME entry: EC 2.1.1.359

Accepted Name
[Histone H3]-lysine(36) N-trimethyltransferase.
Reaction catalysed
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(36)
Comment(s)
  • The enzyme, characterized from yeast, catalyzes the successive methylation of lysine(36) of histone H3 (H3K36), forming the trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II.
  • In mammals this activity is catalyzed by two different enzymes, EC 2.1.1.357 and EC 2.1.1.358.
  • Formerly EC 2.1.1.34.
Cross-references
BRENDA2.1.1.359
EC2PDB2.1.1.359
ExplorEnz2.1.1.359
PRIAM enzyme-specific profiles2.1.1.359
KEGG Ligand Database for Enzyme Nomenclature2.1.1.359
IUBMB Enzyme Nomenclature2.1.1.359
IntEnz2.1.1.359
MEDLINEFind literature relating to 2.1.1.359
MetaCyc2.1.1.359

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-