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ENZYME

ENZYME entry: EC 2.1.1.359

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.359
Accepted Name
[histone H3]-lysine(36) N-trimethyltransferase
Reaction catalysed
L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • The enzyme, characterized from yeast, catalyzes the successive methylation of lysine(36) of histone H3 (H3K36), forming the trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II.
  • In mammals this activity is catalyzed by two different enzymes, EC 2.1.1.357 and EC 2.1.1.358.
Cross-references
BRENDA2.1.1.359
EC2PDB2.1.1.359
ExplorEnz2.1.1.359
KEGG Ligand Database for Enzyme Nomenclature2.1.1.359
IUBMB Enzyme Nomenclature2.1.1.359
MEDLINEFind literature relating to 2.1.1.359
MetaCyc2.1.1.359
Rhea expert-curated reactions2.1.1.359
UniProtKB/Swiss-Prot
Q9NR48, ASH1L_HUMANQ99MY8, ASH1L_MOUSEQ6P2A1, PRDM9_DANRE
Q9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RAT
Q4WTT2, SET2_ASPFUQ2UTN6, SET2_ASPORQ59XV0, SET2_CANAL
Q6FX50, SET2_CANGAQ2H988, SET2_CHAGBQ1DU03, SET2_COCIM
P0CO28, SET2_CRYD1P0CO29, SET2_CRYD3Q6BM04, SET2_DEBHA
Q9VYD1, SET2_DROMEQ5ASA5, SET2_EMENIQ757Y8, SET2_EREGS
Q4IB50, SET2_GIBZEQ6CXP5, SET2_KLULAQ4PBL3, SET2_MYCMD
Q7RZU4, SET2_NEUCRO14026, SET2_SCHPOQ6C5G5, SET2_YARLI
P46995, SET2_YEASTQ9BYW2, SETD2_HUMANE9Q5F9, SETD2_MOUSE
Q9C0A6, SETD5_HUMANQ5XJV7, SETD5_MOUSEQ8IE95, SETVS_PLAF7
Q5ZIZ2, SMYD5_CHICKF1RET2, SMYD5_DANREQ6GMV2, SMYD5_HUMAN
Q3TYX3, SMYD5_MOUSEQ6GPQ4, SMYD5_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-