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ENZYME entry: EC 2.1.1.375

Accepted Name
NNS virus cap methyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + G(5')pppAACA-[mRNA] <=> 2 S-adenosyl-L-homocysteine + m(7)G(5')pppAmACA-[mRNA]
Comment(s)
  • The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyzes two successive methylations.
  • In higher eukaryotes the two methylations occur in the reverse order and are catalyzed by two different enzymes (cf. EC 2.1.1.56 and EC 2.1.1.57) that do not required a specific motif.
Cross-references
BRENDA2.1.1.375
EC2PDB2.1.1.375
ExplorEnz2.1.1.375
PRIAM enzyme-specific profiles2.1.1.375
KEGG Ligand Database for Enzyme Nomenclature2.1.1.375
IUBMB Enzyme Nomenclature2.1.1.375
IntEnz2.1.1.375
MEDLINEFind literature relating to 2.1.1.375
MetaCyc2.1.1.375
Rhea expert-curated reactions2.1.1.375
UniProtKB/Swiss-Prot
Q9QSP0, L_ABLVB;  Q8JTG9, L_ABLVH;  Q2Y2L8, L_AMPV1;  
Q9E784, L_BEFVB;  O91940, L_BRSVA;  P24658, L_CDVO;  
P13179, L_CHAV;  C6S3N3, L_DMSVA;  A4UHQ2, L_EBLV1;  
A4UHQ7, L_EBLV2;  Q91DD4, L_EBORE;  Q8JPX5, L_EBORR;  
Q66802, L_EBOSM;  Q5XX01, L_EBOSU;  Q6V1Q2, L_EBOZ5;  
Q05318, L_EBOZM;  O89344, L_HENDH;  Q77SJ8, L_HIRRV;  
Q6WB93, L_HMPVC;  P20894, L_HRSV;  P28887, L_HRSVA;  
O36635, L_HRSVB;  Q9IWW8, L_HRSVL;  Q82707, L_IHNVO;  
Q82685, L_IHNVW;  Q5K2K3, L_ISFV;  Q8B0U2, L_LBVAV;  
Q4W382, L_LNYV3;  Q1PD54, L_MABVA;  P31352, L_MABVM;  
Q6UY63, L_MABVO;  P35262, L_MABVP;  Q1PDC4, L_MABVR;  
P35975, L_MEASA;  Q9WMB3, L_MEASC;  P12576, L_MEASE;  
Q6E0W6, L_MMVR;  P0C568, L_MOKV;  Q50EW2, L_MPV15;  
P30929, L_MUMPM;  P11205, L_NDVB;  Q9DLD3, L_NDVB1;  
Q997F0, L_NIPAV;  P35946, L_PHODV;  P26676, L_PI2HT;  
P12577, L_PI3H4;  Q88434, L_PIV5;  Q03396, L_PIV5W;  
Q4F8Z9, L_RABVA;  Q66T60, L_RABVB;  Q0GBX5, L_RABVD;  
A3F5L9, L_RABVE;  Q8B6J5, L_RABVH;  A3RM23, L_RABVI;  
Q9IPJ5, L_RABVN;  P11213, L_RABVP;  Q0GBY0, L_RABVR;  
P16289, L_RABVS;  P41357, L_RINDR;  O10378, L_RYSV;  
Q9DUD8, L_SENDA;  P06829, L_SENDE;  Q06996, L_SENDF;  
O55528, L_SENDO;  P06447, L_SENDZ;  Q9QJT4, L_SHRV;  
P35341, L_SV41;  Q91DR9, L_SVCV;  P31332, L_SYNV;  
Q5GA85, L_TAVCV;  D8V078, L_TIBVC;  Q4VKV2, L_TUPVT;  
P03523, L_VSIVA;  Q8B0H0, L_VSIVC;  Q98776, L_VSIVM;  
Q8B0I0, L_VSIVN;  Q8B0H5, L_VSIVS;  P13615, L_VSNJH;  
P16379, L_VSNJO;  

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