ENZYME entry: EC 6.3.1.14
Accepted Name |
diphthine--ammonia ligase.
|
Alternative Name(s) |
diphthamide synthase. |
diphthamide synthetase. |
Reaction catalysed |
ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) |
Comment(s) |
- This amidase catalyzes the last step in the conversion of an
L-histidine residue in the translation elongation factor translation
elongation factor 2 to diphthamide.
- This factor is found in all archaebacteria and eukaryotes, but not in
eubacteria, and is the target of bacterial toxins such as the
diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36).
- The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98.
- Formerly EC 6.3.2.22.
|
Cross-references |
BRENDA | 6.3.1.14 |
EC2PDB | 6.3.1.14 |
ExplorEnz | 6.3.1.14 |
PRIAM enzyme-specific profiles | 6.3.1.14 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.1.14 |
IUBMB Enzyme Nomenclature | 6.3.1.14 |
IntEnz | 6.3.1.14 |
MEDLINE | Find literature relating to 6.3.1.14 |
MetaCyc | 6.3.1.14 |
Rhea expert-curated reactions | 6.3.1.14 |
UniProtKB/Swiss-Prot |
|
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