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ENZYME entry: EC 6.3.1.14

Accepted Name
Diphthine--ammonia ligase.
Alternative Name(s)
Diphthamide synthase.
Diphthamide synthetase.
Reaction catalysed
ATP + diphthine-[translation elongation factor 2] + NH(3) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2]
Comment(s)
  • This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor translation elongation factor 2 to diphthamide.
  • This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36).
  • The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98.
  • Formerly EC 6.3.2.22.
Cross-references
BRENDA6.3.1.14
EC2PDB6.3.1.14
ExplorEnz6.3.1.14
PRIAM enzyme-specific profiles6.3.1.14
KEGG Ligand Database for Enzyme Nomenclature6.3.1.14
IUBMB Enzyme Nomenclature6.3.1.14
IntEnz6.3.1.14
MEDLINEFind literature relating to 6.3.1.14
MetaCyc6.3.1.14
Rhea expert-curated reactions6.3.1.14
UniProtKB/Swiss-Prot
Q2HJF5, DPH6_BOVIN;  A2RV01, DPH6_DANRE;  Q7L8W6, DPH6_HUMAN;  
Q9CQ28, DPH6_MOUSE;  Q5M9F5, DPH6_RAT;  Q9USQ7, DPH6_SCHPO;  
Q12429, DPH6_YEAST;  

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