Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the incovenience.

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Diphthine--ammonia ligase.
Alternative Name(s)
Diphthamide synthase.
Diphthamide synthetase.
Reaction catalysed
ATP + diphthine-[translation elongation factor 2] + NH(3) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2]
  • This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor translation elongation factor 2 to diphthamide.
  • This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC
  • The substrate of the enzyme, diphthine, is produced by EC
  • Formerly EC
PRIAM enzyme-specific profiles6.3.1.14
KEGG Ligand Database for Enzyme Nomenclature6.3.1.14
IUBMB Enzyme Nomenclature6.3.1.14
MEDLINEFind literature relating to
Q12429, DPH6_YEAST;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-