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ENZYME entry: EC 126.96.36.1991
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|mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
|mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III.|
|dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA|
- The enzyme, characterized from mycobacteria, provides a link between
the type I and type II fatty acid synthase systems (FAS-I and FAS-II,
respectively) found in these organisms.
- The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16)
produced by the FAS-I system, condensing them with malonyl-[acyl-
carrier protein] (malonyl-AcpM) and forming starter molecules for the
FAS-II system, which elongates them into meromycolic acids.
- The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-
CoA), which are used by EC 188.8.131.52, or branched-chain acyl-CoAs,
which are used by EC 184.108.40.2060.
|PRIAM enzyme-specific profiles||220.127.116.111|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.1681|
|IUBMB Enzyme Nomenclature||22.214.171.1241|
|MEDLINE||Find literature relating to 126.96.36.1991|
|Rhea expert-curated reactions||188.8.131.521|
entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-