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ENZYME entry: EC 2.3.1.301

Accepted Name
mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
Alternative Name(s)
mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III.
Reaction catalysed
dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA
Comment(s)
  • The enzyme, characterized from mycobacteria, provides a link between the type I and type II fatty acid synthase systems (FAS-I and FAS-II, respectively) found in these organisms.
  • The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16) produced by the FAS-I system, condensing them with malonyl-[acyl- carrier protein] (malonyl-AcpM) and forming starter molecules for the FAS-II system, which elongates them into meromycolic acids.
  • The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl- CoA), which are used by EC 2.3.1.180, or branched-chain acyl-CoAs, which are used by EC 2.3.1.300.
Cross-references
BRENDA2.3.1.301
EC2PDB2.3.1.301
ExplorEnz2.3.1.301
PRIAM enzyme-specific profiles2.3.1.301
KEGG Ligand Database for Enzyme Nomenclature2.3.1.301
IUBMB Enzyme Nomenclature2.3.1.301
IntEnz2.3.1.301
MEDLINEFind literature relating to 2.3.1.301
MetaCyc2.3.1.301
Rhea expert-curated reactions2.3.1.301
UniProtKB/Swiss-Prot
A0QLF3, FABH_MYCA1;  P0A575, FABH_MYCBO;  A1KG10, FABH_MYCBP;  
C1AKL3, FABH_MYCBT;  B2HRM4, FABH_MYCMM;  Q73SP5, FABH_MYCPA;  
A5TZR3, FABH_MYCTA;  P9WNG2, FABH_MYCTO;  P9WNG3, FABH_MYCTU;  
A0PLS8, FABH_MYCUA;  

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