Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.301

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.301
Accepted Name
mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III
Alternative Name(s)
mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III
Reaction catalysed
malonyl-[ACP] + dodecanoyl-CoA + H(+) = 3-oxotetradecanoyl-[ACP] + CO2 + CoA
Comment(s)
  • The enzyme, characterized from mycobacteria, provides a link between the type I and type II fatty acid synthase systems (FAS-I and FAS-II, respectively) found in these organisms.
  • The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16) produced by the FAS-I system, condensing them with malonyl-[acyl- carrier protein] (malonyl-AcpM) and forming starter molecules for the FAS-II system, which elongates them into meromycolic acids.
  • The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl- CoA), which are used by EC 2.3.1.180, or branched-chain acyl-CoAs, which are used by EC 2.3.1.300.
Cross-references
BRENDA2.3.1.301
EC2PDB2.3.1.301
ExplorEnz2.3.1.301
KEGG Ligand Database for Enzyme Nomenclature2.3.1.301
IUBMB Enzyme Nomenclature2.3.1.301
MEDLINEFind literature relating to 2.3.1.301
MetaCyc2.3.1.301
Rhea expert-curated reactions2.3.1.301
UniProtKB/Swiss-Prot
A0QLF3, FABH_MYCA1P0A575, FABH_MYCBOA1KG10, FABH_MYCBP
C1AKL3, FABH_MYCBTB2HRM4, FABH_MYCMMQ73SP5, FABH_MYCPA
A5TZR3, FABH_MYCTAP9WNG2, FABH_MYCTOP9WNG3, FABH_MYCTU
A0PLS8, FABH_MYCUA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-