ENZYME entry: EC 184.108.40.2061
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|Mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
|Mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III.|
|Dodecanoyl-CoA + a malonyl-[acyl-carrier protein] <=> a 3-oxotetradecanoyl-[acyl-carrier protein] + CoA + CO(2)|
- The enzyme, characterized from mycobacteria, provides a link between
the type I and type II fatty acid synthase systems (FAS-I and FAS-II,
respectively) found in these organisms.
- The enzyme acts on medium- and long-chain acyl-CoAs (C(12)-C(16))
produced by the FAS-I system, condensing them with malonyl-[acyl-
carrier protein] (malonyl-AcpM) and forming starter molecules for the
FAS-II system, which elongates them into meromycolic acids.
- The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-
CoA), which are used by EC 220.127.116.11, or branched-chain acyl-CoAs,
which are used by EC 18.104.22.1680.
|PRIAM enzyme-specific profiles||22.214.171.1241|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.1991|
|IUBMB Enzyme Nomenclature||188.8.131.521|
|MEDLINE||Find literature relating to 184.108.40.2061|
|Rhea expert-curated reactions||220.127.116.111|
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