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ENZYME entry: EC

Accepted Name
dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase.
Alternative Name(s)
Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase.
Reaction catalysed
a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • ALG9 mannosyltransferase catalyzes the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-dolichol (EC and the addition of alpha-1,2- mannose to Man8GlcNAc2-PP-dolichol (EC
  • Formerly EC
PRIAM enzyme-specific profiles2.4.1.259
KEGG Ligand Database for Enzyme Nomenclature2.4.1.259
IUBMB Enzyme Nomenclature2.4.1.259
MEDLINEFind literature relating to
Rhea expert-curated reactions2.4.1.259
Q9FZ49, ALG9_ARATH;  P54002, ALG9_CAEEL;  Q9H6U8, ALG9_HUMAN;  

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