Expasy logo

ENZYME

ENZYME entry: EC 2.4.1.261

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.261
Accepted Name
dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
Alternative Name(s)
Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase
Reaction catalysed
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • ALG9 mannosyltransferase catalyzes the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2- mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261).
  • Formerly EC 2.4.1.130.
Cross-references
Rhea expert-curated reactions2.4.1.261
ExplorEnz2.4.1.261
IUBMB Enzyme Nomenclature2.4.1.261
UniProtKB/Swiss-Prot
Q9FZ49, ALG9_ARATHP54002, ALG9_CAEELQ9VBV8, ALG9_DROME
Q9H6U8, ALG9_HUMANQ8VDI9, ALG9_MOUSEQ9P7Q9, ALG9_SCHPO
P53868, ALG9_YEAST
BRENDA2.4.1.261
MetaCyc2.4.1.261
KEGG Ligand Database for Enzyme Nomenclature2.4.1.261
EC2PDB2.4.1.261
MEDLINEFind literature relating to 2.4.1.261

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-