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ENZYME entry: EC 2.4.1.261

Accepted Name
dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase.
Alternative Name(s)
Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase.
Reaction catalysed
a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • ALG9 mannosyltransferase catalyzes the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2- mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261).
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.261
EC2PDB2.4.1.261
ExplorEnz2.4.1.261
PRIAM enzyme-specific profiles2.4.1.261
KEGG Ligand Database for Enzyme Nomenclature2.4.1.261
IUBMB Enzyme Nomenclature2.4.1.261
IntEnz2.4.1.261
MEDLINEFind literature relating to 2.4.1.261
MetaCyc2.4.1.261
Rhea expert-curated reactions2.4.1.261
UniProtKB/Swiss-Prot
Q9FZ49, ALG9_ARATH;  P54002, ALG9_CAEEL;  Q9H6U8, ALG9_HUMAN;  
Q8VDI9, ALG9_MOUSE;  Q9P7Q9, ALG9_SCHPO;  P53868, ALG9_YEAST;  

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