Due to maintenance work, this service will be unavailable Mon Feb 13 between
07:00 and
09:30 -
CET.
Apologies for the inconvenience.
ENZYME entry: EC 2.6.1.93
Accepted Name |
neamine transaminase.
|
Alternative Name(s) |
glutamate--6'-dehydroparomamine aminotransferase. |
Reaction catalysed |
2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate |
Comment(s) |
- The reaction occurs in vivo in the opposite direction.
- Involved in the biosynthetic pathways of several clinically important
aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin
and ribostamycin.
- Works in combination with EC 1.1.3.43 to replace the 6'-hydroxy group
of paromamine with an amino group.
- The enzyme from the bacterium Streptomyces kanamyceticus can also
catalyze EC 2.6.1.94, which leads to production of kanamycin A.
- The enzyme from the bacterium Streptomyces fradiae can also catalyze
EC 2.6.1.95, leading to production of neomycin C.
|
Cross-references |
BRENDA | 2.6.1.93 |
EC2PDB | 2.6.1.93 |
ExplorEnz | 2.6.1.93 |
PRIAM enzyme-specific profiles | 2.6.1.93 |
KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.93 |
IUBMB Enzyme Nomenclature | 2.6.1.93 |
IntEnz | 2.6.1.93 |
MEDLINE | Find literature relating to 2.6.1.93 |
MetaCyc | 2.6.1.93 |
Rhea expert-curated reactions | 2.6.1.93 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-