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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.6.1.93

Accepted Name
Neamine transaminase.
Alternative Name(s)
Glutamate--6'-dehydroparomamine aminotransferase.
Reaction catalysed
Neamine + 2-oxoglutarate <=> 6'-dehydroparomamine + L-glutamate
Comment(s)
  • The reaction occurs in vivo in the opposite direction.
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin.
  • Works in combination with EC 1.1.3.43 to replace the 6'-hydroxy group of paromamine with an amino group.
  • The enzyme from the bacterium Streptomyces kanamyceticus can also catalyze EC 2.6.1.94, which leads to production of kanamycin A.
  • The enzyme from the bacterium Streptomyces fradiae can also catalyze EC 2.6.1.95, leading to production of neomycin C.
Cross-references
BRENDA2.6.1.93
EC2PDB2.6.1.93
ExplorEnz2.6.1.93
PRIAM enzyme-specific profiles2.6.1.93
KEGG Ligand Database for Enzyme Nomenclature2.6.1.93
IUBMB Enzyme Nomenclature2.6.1.93
IntEnz2.6.1.93
MEDLINEFind literature relating to 2.6.1.93
MetaCyc2.6.1.93
UniProtKB/Swiss-Prot
Q4H4F5, BTRB_BACCI;  Q6L741, KACL_STRKN;  Q53U08, NEON_STRFR;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-