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ENZYME entry: EC 2.6.1.95

Accepted Name
Neomycin C transaminase.
Reaction catalysed
Neomycin C + 2-oxoglutarate <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate
Comment(s)
  • The reaction occurs in vivo in the opposite direction.
  • Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family.
  • Works in combination with EC 1.1.3.44 to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group.
  • The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyze EC 2.6.1.93.
Cross-references
BRENDA2.6.1.95
EC2PDB2.6.1.95
ExplorEnz2.6.1.95
PRIAM enzyme-specific profiles2.6.1.95
KEGG Ligand Database for Enzyme Nomenclature2.6.1.95
IUBMB Enzyme Nomenclature2.6.1.95
IntEnz2.6.1.95
MEDLINEFind literature relating to 2.6.1.95
MetaCyc2.6.1.95
Rhea expert-curated reactions2.6.1.95
UniProtKB/Swiss-Prot
Q53U08, NEON_STRFR

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