ENZYME entry: EC 2.6.1.95
| Accepted Name |
|---|
| Neomycin C transaminase.
|
| Reaction catalysed |
|---|
| Neomycin C + 2-oxoglutarate <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate |
| Comment(s) |
|---|
- The reaction occurs in vivo in the opposite direction.
- Involved in the biosynthetic pathway of aminoglycoside antibiotics of
the neomycin family.
- Works in combination with EC 1.1.3.44 to replace the 6'''-hydroxy
group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group.
- The enzyme, characterized from the bacterium Streptomyces fradiae,
can also catalyze EC 2.6.1.93.
|
| Cross-references |
|---|
| BRENDA | 2.6.1.95 |
| EC2PDB | 2.6.1.95 |
| ExplorEnz | 2.6.1.95 |
| PRIAM enzyme-specific profiles | 2.6.1.95 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.6.1.95 |
| IUBMB Enzyme Nomenclature | 2.6.1.95 |
| IntEnz | 2.6.1.95 |
| MEDLINE | Find literature relating to 2.6.1.95 |
| MetaCyc | 2.6.1.95 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
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