Expasy logo

ENZYME

ENZYME entry: EC 3.1.4.52

PURL: https://purl.expasy.org/enzyme/EC/3.1.4.52
Accepted Name
cyclic-guanylate-specific phosphodiesterase
Alternative Name(s)
c-di-GMP-specific phosphodiesterase
PDEA1
phosphodiesterase A1
Reaction catalysed
3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)
Comment(s)
  • Inhibited by Ca(2+) and Zn(2+).
  • Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive.
  • It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
Cross-references
BRENDA3.1.4.52
EC2PDB3.1.4.52
ExplorEnz3.1.4.52
KEGG Ligand Database for Enzyme Nomenclature3.1.4.52
IUBMB Enzyme Nomenclature3.1.4.52
MEDLINEFind literature relating to 3.1.4.52
MetaCyc3.1.4.52
Rhea expert-curated reactions3.1.4.52
UniProtKB/Swiss-Prot
Q9KVK6, CDGJ_VIBCHQ9KVL2, CDPA_VIBCHQ9I0R8, CDPD3_PSEAE
P76129, DOSP_ECOLIQ9I310, MUCR_PSEAEQ9HYT3, NBDA_PSEAE
O51338, PDEA_BORBUP23842, PDEA_ECOLIP77473, PDEB_ECOLI
Q8EJM6, PDEB_SHEONP32701, PDEC_ECOLIP76261, PDED_ECOLI
P77172, PDEF_ECOLIP75995, PDEG_ECOLIP37646, PDEH_ECOLI
P75800, PDEI_ECOLIP37649, PDEK_ECOLIP21514, PDEL_ECOLI
P76446, PDEN_ECOLIP77334, PDER_ECOLIQ9HX69, ROCR_PSEAE
Q87NI7, TPDA_VIBPA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-