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ENZYME

ENZYME entry: EC 3.1.4.52

Accepted Name
cyclic-guanylate-specific phosphodiesterase
Alternative Name(s)
c-di-GMP-specific phosphodiesterase
PDEA1
phosphodiesterase A1
Reaction catalysed
3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)
Comment(s)
  • Inhibited by Ca(2+) and Zn(2+).
  • Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive.
  • It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
Cross-references
BRENDA3.1.4.52
EC2PDB3.1.4.52
ExplorEnz3.1.4.52
PRIAM enzyme-specific profiles3.1.4.52
KEGG Ligand Database for Enzyme Nomenclature3.1.4.52
IUBMB Enzyme Nomenclature3.1.4.52
IntEnz3.1.4.52
MEDLINEFind literature relating to 3.1.4.52
MetaCyc3.1.4.52
Rhea expert-curated reactions3.1.4.52
UniProtKB/Swiss-Prot
Q9KVK6, CDGJ_VIBCHQ9KVL2, CDPA_VIBCHQ9I0R8, CDPD3_PSEAE
P76129, DOSP_ECOLIO51338, PDEA_BORBUP23842, PDEA_ECOLI
P77473, PDEB_ECOLIQ8EJM6, PDEB_SHEONP32701, PDEC_ECOLI
P76261, PDED_ECOLIP77172, PDEF_ECOLIP75995, PDEG_ECOLI
P37646, PDEH_ECOLIP75800, PDEI_ECOLIP37649, PDEK_ECOLI
P21514, PDEL_ECOLIP76446, PDEN_ECOLIP77334, PDER_ECOLI
Q9HX69, ROCR_PSEAEQ87NI7, TPDA_VIBPA

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