A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.1.4.52
| Accepted Name |
|---|
| Cyclic-guanylate-specific phosphodiesterase.
|
| Alternative Name(s) |
|---|
| C-di-GMP-specific phosphodiesterase. |
| PDEA1. |
| Phosphodiesterase A1. |
| Reaction catalysed |
|---|
| Cyclic di-3',5'-guanylate + H(2)O <=> 5'-phosphoguanylyl(3'->5')guanosine |
| Cofactor(s) |
|---|
| Heme; Mg(2+); Mn(2+).
|
| Comment(s) |
|---|
- Inhibited by Ca(2+) and Zn(2+).
- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and
an allosteric activator of EC 2.4.1.12 rendering it inactive.
- It is the balance between these two enzymes that determines the
cellular level of cyclic di-3',5'-guanylate.
|
| Cross-references |
|---|
| BRENDA | 3.1.4.52 |
| EC2PDB | 3.1.4.52 |
| ExplorEnz | 3.1.4.52 |
| PRIAM enzyme-specific profiles | 3.1.4.52 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.52 |
| IUBMB Enzyme Nomenclature | 3.1.4.52 |
| IntEnz | 3.1.4.52 |
| MEDLINE | Find literature relating to 3.1.4.52 |
| MetaCyc | 3.1.4.52 |
| UniProtKB/Swiss-Prot |
| Q9KVK6, CDGJ_VIBCH; | Q9KVL2, CDPA_VIBCH; | P76129, DOSP_ECOLI; |
| O51338, PDEA_BORBU; | P23842, PDEA_ECOLI; | P77473, PDEB_ECOLI; |
| Q8EJM6, PDEB_SHEON; | P32701, PDEC_ECOLI; | P76261, PDED_ECOLI; |
| P77172, PDEF_ECOLI; | P75995, PDEG_ECOLI; | P37646, PDEH_ECOLI; |
| P75800, PDEI_ECOLI; | P37649, PDEK_ECOLI; | P21514, PDEL_ECOLI; |
| P76446, PDEN_ECOLI; | P77334, PDER_ECOLI; |
|
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