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ENZYME

ENZYME entry: EC 3.2.2.5

PURL: https://purl.expasy.org/enzyme/EC/3.2.2.5
Accepted Name
NAD(+) glycohydrolase
Alternative Name(s)
ADP-ribosyl cyclase
beta-NAD(+) glycohydrolase
diphosphopyridine nucleosidase
DPNase
DPN hydrolase
NAD(+) nucleosidase
NADase
NAD glycohydrolase
NAD nucleosidase
nicotinamide adenine dinucleotide glycohydrolase
nicotinamide adenine dinucleotide nucleosidase
Reaction catalysed
NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)
Comment(s)
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5.
Cross-references
BRENDA3.2.2.5
EC2PDB3.2.2.5
ExplorEnz3.2.2.5
KEGG Ligand Database for Enzyme Nomenclature3.2.2.5
IUBMB Enzyme Nomenclature3.2.2.5
MEDLINEFind literature relating to 3.2.2.5
MetaCyc3.2.2.5
Rhea expert-curated reactions3.2.2.5
UniProtKB/Swiss-Prot
A0A5D0EMF2, CAP12_AGGACA0A381HAP5, CAP12_CAPGBP0DUD9, CAP12_FLADA
P0DUE0, CAP12_LACSXA0A1G6LGU2, CAP12_NIADEA0A2T5Y4G4, CAP12_SPHFK
A0A0H3MAA9, CPNT_MYCBPO05442, CPNT_MYCTUP0DXN8, DSR2_BACIU
Q4WL81, NADA_ASPFUQ7S936, NADA_NEUCRP17981, NAR2A_MOUSE
P17982, NAR2A_RATO35975, NAR2B_MOUSEP20974, NAR2B_RAT
A0A0J5WTU0, PCTIR_BURCEP0DV41, PCTIR_PSEAIA0A1V0HUU2, PCTIR_RHOS2
P0DV29, PCTIR_XANPEP0DW59, THSA_ACIB7J8G6Z1, THSA_BACCS
A0A5B8Z1N3, THSA_CYTDAP0DW60, THSA_ENTFCC0MAL8, THSA_STRE4
Q9I739, TSE6_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-