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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
NAD(+) glycohydrolase.
Alternative Name(s)
ADP-ribosyl cyclase.
Beta-NAD(+) glycohydrolase.
Diphosphopyridine nucleosidase.
DPN hydrolase.
NAD glycohydrolase.
NAD nucleosidase.
NAD(+) nucleosidase.
Nicotinamide adenine dinucleotide glycohydrolase.
Nicotinamide adenine dinucleotide nucleosidase.
Reaction catalysed
NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC
PRIAM enzyme-specific profiles3.2.2.5
KEGG Ligand Database for Enzyme Nomenclature3.2.2.5
IUBMB Enzyme Nomenclature3.2.2.5
MEDLINEFind literature relating to
P17982, NAR2A_RAT;  O35975, NAR2B_MOUSE;  P20974, NAR2B_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-