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ENZYME entry: EC 3.2.2.5

Accepted Name
NAD(+) glycohydrolase.
Alternative Name(s)
ADP-ribosyl cyclase.
beta-NAD(+) glycohydrolase.
diphosphopyridine nucleosidase.
DPNase.
DPN hydrolase.
NAD(+) nucleosidase.
NADase.
NAD glycohydrolase.
NAD nucleosidase.
nicotinamide adenine dinucleotide glycohydrolase.
nicotinamide adenine dinucleotide nucleosidase.
Reaction catalysed
H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide
Comment(s)
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5.
Cross-references
BRENDA3.2.2.5
EC2PDB3.2.2.5
ExplorEnz3.2.2.5
PRIAM enzyme-specific profiles3.2.2.5
KEGG Ligand Database for Enzyme Nomenclature3.2.2.5
IUBMB Enzyme Nomenclature3.2.2.5
IntEnz3.2.2.5
MEDLINEFind literature relating to 3.2.2.5
MetaCyc3.2.2.5
Rhea expert-curated reactions3.2.2.5
UniProtKB/Swiss-Prot
A0A5D0EMF2, CAP12_AGGAC;  A0A381HAP5, CAP12_CAPGB;  P0DUD9, CAP12_FLADA;  
P0DUE0, CAP12_LACSX;  A0A1G6LGU2, CAP12_NIADE;  A0A2T5Y4G4, CAP12_SPHFK;  
A0A0H3MAA9, CPNT_MYCBP;  O05442, CPNT_MYCTU;  Q4WL81, NADA_ASPFU;  
Q7S936, NADA_NEUCR;  P17981, NAR2A_MOUSE;  P17982, NAR2A_RAT;  
O35975, NAR2B_MOUSE;  P20974, NAR2B_RAT;  A0A0J5WTU0, PCTIR_BURCE;  
P0DV41, PCTIR_PSEAI;  A0A1V0HUU2, PCTIR_RHOS2;  P0DV29, PCTIR_XANPE;  
J8G6Z1, THSA_BACCS;  A0A5B8Z1N3, THSA_BACDA;  Q9I739, TSE6_PSEAE;  

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