A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.2.2.5
| Accepted Name |
|---|
| NAD(+) glycohydrolase.
|
| Alternative Name(s) |
|---|
| ADP-ribosyl cyclase. |
| Beta-NAD(+) glycohydrolase. |
| Diphosphopyridine nucleosidase. |
| DPN hydrolase. |
| DPNase. |
| NAD glycohydrolase. |
| NAD nucleosidase. |
| NAD(+) nucleosidase. |
| NADase. |
| Nicotinamide adenine dinucleotide glycohydrolase. |
| Nicotinamide adenine dinucleotide nucleosidase. |
| Reaction catalysed |
|---|
| NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide |
| Comment(s) |
|---|
- This enzyme catalyzes the hydrolysis of NAD(+), without associated
ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6,
bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
- The enzyme from Group A streptococci has been implicated in the
pathogenesis of diseases such as streptococcal toxic shock-like
syndrome (STSS) and necrotizing fasciitis.
- The enzyme from the venom of the snake Agkistrodon acutus also
catalyzes EC 3.6.1.5.
|
| Cross-references |
|---|
| BRENDA | 3.2.2.5 |
| EC2PDB | 3.2.2.5 |
| ExplorEnz | 3.2.2.5 |
| PRIAM enzyme-specific profiles | 3.2.2.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.2.5 |
| IUBMB Enzyme Nomenclature | 3.2.2.5 |
| IntEnz | 3.2.2.5 |
| MEDLINE | Find literature relating to 3.2.2.5 |
| MetaCyc | 3.2.2.5 |
| UniProtKB/Swiss-Prot |
|
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