ENZYME entry: EC 3.2.2.5
Accepted Name |
NAD(+) glycohydrolase.
|
Alternative Name(s) |
ADP-ribosyl cyclase. |
Beta-NAD(+) glycohydrolase. |
Diphosphopyridine nucleosidase. |
DPN hydrolase. |
DPNase. |
NAD glycohydrolase. |
NAD nucleosidase. |
NAD(+) nucleosidase. |
NADase. |
Nicotinamide adenine dinucleotide glycohydrolase. |
Nicotinamide adenine dinucleotide nucleosidase. |
Reaction catalysed |
NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide |
Comment(s) |
- This enzyme catalyzes the hydrolysis of NAD(+), without associated
ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6,
bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
- The enzyme from Group A streptococci has been implicated in the
pathogenesis of diseases such as streptococcal toxic shock-like
syndrome (STSS) and necrotizing fasciitis.
- The enzyme from the venom of the snake Agkistrodon acutus also
catalyzes EC 3.6.1.5.
|
Cross-references |
BRENDA | 3.2.2.5 |
EC2PDB | 3.2.2.5 |
ExplorEnz | 3.2.2.5 |
PRIAM enzyme-specific profiles | 3.2.2.5 |
KEGG Ligand Database for Enzyme Nomenclature | 3.2.2.5 |
IUBMB Enzyme Nomenclature | 3.2.2.5 |
IntEnz | 3.2.2.5 |
MEDLINE | Find literature relating to 3.2.2.5 |
MetaCyc | 3.2.2.5 |
Rhea expert-curated reactions | 3.2.2.5 |
UniProtKB/Swiss-Prot |
A0A5D0EMF2, CAP12_AGGAC; | A0A381HAP5, CAP12_CAPGB; | P0DUD9, CAP12_FLADA; |
P0DUE0, CAP12_LACSX; | A0A1G6LGU2, CAP12_NIADE; | A0A2T5Y4G4, CAP12_SPHFK; |
A0A0H3MAA9, CPNT_MYCBP; | O05442, CPNT_MYCTU; | Q4WL81, NADA_ASPFU; |
Q7S936, NADA_NEUCR; | P17981, NAR2A_MOUSE; | P17982, NAR2A_RAT; |
O35975, NAR2B_MOUSE; | P20974, NAR2B_RAT; | A0A0J5WTU0, PCTIR_BURCE; |
P0DV41, PCTIR_PSEAI; | A0A1V0HUU2, PCTIR_RHOS2; | P0DV29, PCTIR_XANPE; |
Q9I739, TSE6_PSEAE; |
|
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