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ENZYME entry: EC

Accepted Name
aqualysin 1
Alternative Name(s)
Reaction catalysed
Exhibits low specificity toward esters of amino acids with small hydrophobic or aromatic residues at the P1 position
  • This enzyme from the extreme thermophile, Thermus aquaticus, is an alkaline serine peptidase.
  • It has three subsites, S1, S2, and S3, in the substrate binding site.
  • The preferred amino acids at the S1 site are Ala and Phe, at the S2 site are Ala and norleucine and at the S3 site are Phe and Ile.
  • These specificities are similar to those of EC and EC
  • The enzyme displays broad specificity for cleavage of insulin B-chain and hydrolyzes elastin substrates such as succinyl-(Ala)n-p- nitroanilide (n = 1,2,3) and some peptide esters.
  • Belongs to peptidase family S8A.
PRIAM enzyme-specific profiles3.4.21.111
KEGG Ligand Database for Enzyme Nomenclature3.4.21.111
IUBMB Enzyme Nomenclature3.4.21.111
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.21.111
P08594, AQL1_THEAQ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-