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ENZYME

ENZYME entry: EC 3.4.21.122

Accepted Name
transmembrane protease serine 2
Alternative Name(s)
epitheliasin
Reaction catalysed
The enzyme cleaves angiotensin-converting enzyme 2 (EC 3.4.17.23) and cleaves influenzea A and B virus and coronavirus spike glycoproteins at arginine residues
Comment(s)
  • The enzyme, present in mammalia, cleaves and inactivates EC 3.4.17.23 at arginine residues in the region R697 to R716, which enhances influenza and coronavirus uptake.
  • The enzyme also cleaves and activates influenza and coronavirus spike glycoproteins and thus facilitates virus-cell membrane fusions.
  • The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site at SKPSKR/SFIEDL, while the cleavage of MERS-COV glycoprotein occurs at GSRSAR/SAIEDL.
Cross-references
BRENDA3.4.21.122
EC2PDB3.4.21.122
ExplorEnz3.4.21.122
PRIAM enzyme-specific profiles3.4.21.122
KEGG Ligand Database for Enzyme Nomenclature3.4.21.122
IUBMB Enzyme Nomenclature3.4.21.122
IntEnz3.4.21.122
MEDLINEFind literature relating to 3.4.21.122
MetaCyc3.4.21.122
Rhea expert-curated reactions3.4.21.122
UniProtKB/Swiss-Prot
O15393, TMPS2_HUMANQ9JIQ8, TMPS2_MOUSE

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