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ENZYME entry: EC 3.4.22.59

Accepted Name
Caspase-6.
Alternative Name(s)
Apoptotic protease Mch-2.
CASP-6.
Mch2.
Reaction catalysed
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Comment(s)
  • Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60).
  • These caspases are responsible for the proteolysis of the majority of cellular polypeptides, (e.g. poly(ADP-ribose) polymerase (PARP)), which lead to the apoptotic phenotype.
  • Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to cytochrome c release from the mitochondria; the release of cytochrome c, which is an essential component of the intrinsic apoptosis pathway.
  • Can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragementation in the final phases of apoptosis.
  • Belongs to peptidase family C14.
Cross-references
PROSITEPDOC00864
BRENDA3.4.22.59
EC2PDB3.4.22.59
ExplorEnz3.4.22.59
PRIAM enzyme-specific profiles3.4.22.59
KEGG Ligand Database for Enzyme Nomenclature3.4.22.59
IUBMB Enzyme Nomenclature3.4.22.59
IntEnz3.4.22.59
MEDLINEFind literature relating to 3.4.22.59
MetaCyc3.4.22.59
Rhea expert-curated reactions3.4.22.59
UniProtKB/Swiss-Prot
Q3T0P5, CASP6_BOVIN;  A0A1D5PPP7, CASP6_CHICK;  P55212, CASP6_HUMAN;  
O08738, CASP6_MOUSE;  O35397, CASP6_RAT;  

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