ENZYME entry: EC 3.4.22.61
Accepted Name |
caspase-8.
|
Alternative Name(s) |
apoptotic cysteine protease. |
apoptotic protease Mch-5. |
CAP4. |
CASP-8. |
FADD-homologous ICE/CED-3-like protease. |
FADD-like ICE. |
FLICE. |
ICE-like apoptotic protease 5. |
MACH. |
mammalian Ced-3 homolog 5. |
Mch5. |
MORT1-associated CED-3 homolog. |
Reaction catalysed |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala) |
Comment(s) |
- Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55),
caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
- Apical activator of the extrinsic (death receptor) apoptosis pathway,
triggered by death receptor ligation.
- Contains two tandem death effector domains (DEDs) in its N-terminal
prodomain, which play a role in procaspase activation.
- Linked to cell surface death receptors such as Fas.
- When Fas is aggregated by the Fas ligand, procaspase-8 is recruited
to the death receptor where it is activated.
- Has a preference for Glu at P3 and prefers small residues, such as
Gly, Ser and Ala at the P1' position.
- Has very broad P4 specificity, tolerating substrates with Asp, Val or
Leu in this position.
- Endogenous substrates for caspase-8 include procaspase-3, the pro-
apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8
activity modulator FLIPL.
- Belongs to peptidase family C14.
|
Cross-references |
BRENDA | 3.4.22.61 |
EC2PDB | 3.4.22.61 |
ExplorEnz | 3.4.22.61 |
PRIAM enzyme-specific profiles | 3.4.22.61 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.61 |
IUBMB Enzyme Nomenclature | 3.4.22.61 |
IntEnz | 3.4.22.61 |
MEDLINE | Find literature relating to 3.4.22.61 |
MetaCyc | 3.4.22.61 |
Rhea expert-curated reactions | 3.4.22.61 |
UniProtKB/Swiss-Prot |
|
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