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ENZYME entry: EC

Accepted Name
Alternative Name(s)
apoptotic protease-activating factor 3.
apoptotic protease Mch-6.
ICE-like apoptotic protease 6.
Reaction catalysed
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
  • Caspase-9 is an initiator caspase, as are caspase-2 (EC, caspase-8 (EC and caspase-10 (EC
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • An alternatively spliced version of caspase-9 also exists, caspase- 9S, that inhibits apoptosis, similar to the situation found with caspase-2.
  • Phosphorylation of caspase-9 from some species by Akt, a serine- threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo.
  • The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage.
  • Procaspase-3 is the enzyme's physiological substrate.
  • Belongs to peptidase family C14.
PRIAM enzyme-specific profiles3.4.22.62
KEGG Ligand Database for Enzyme Nomenclature3.4.22.62
IUBMB Enzyme Nomenclature3.4.22.62
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.22.62
P55211, CASP9_HUMAN;  Q8C3Q9, CASP9_MOUSE;  

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