ENZYME entry: EC 3.4.22.62
| Accepted Name |
|---|
| Caspase-9.
|
| Alternative Name(s) |
|---|
| APAF-3. |
| Apoptotic protease Mch-6. |
| Apoptotic protease-activating factor 3. |
| CASP-9. |
| ICE-LAP6. |
| ICE-like apoptotic protease 6. |
| Reaction catalysed |
|---|
| Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa |
| Comment(s) |
|---|
- Caspase-9 is an initiator caspase, as are caspase-2 (EC 3.4.22.55),
caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63).
- Contains a caspase-recruitment domain (CARD) in its N-terminal
prodomain, which plays a role in procaspase activation.
- An alternatively spliced version of caspase-9 also exists, caspase-
9S, that inhibits apoptosis, similar to the situation found with
caspase-2.
- Phosphorylation of caspase-9 from some species by Akt, a serine-
threonine protein kinase, inhibits caspase activity in vitro and
caspase activation in vivo.
- The activity of caspase-9 is increased dramatically upon association
with the apoptosome but the enzyme can be activated without
proteolytic cleavage.
- Procaspase-3 is the enzyme's physiological substrate.
- Belongs to peptidase family C14.
|
| Cross-references |
|---|
| PROSITE | PDOC00864 |
| BRENDA | 3.4.22.62 |
| EC2PDB | 3.4.22.62 |
| ExplorEnz | 3.4.22.62 |
| PRIAM enzyme-specific profiles | 3.4.22.62 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.62 |
| IUBMB Enzyme Nomenclature | 3.4.22.62 |
| IntEnz | 3.4.22.62 |
| MEDLINE | Find literature relating to 3.4.22.62 |
| MetaCyc | 3.4.22.62 |
| UniProtKB/Swiss-Prot |
|
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