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ENZYME

ENZYME entry: EC 3.4.22.62

Accepted Name
caspase-9
Alternative Name(s)
APAF-3
apoptotic protease-activating factor 3
apoptotic protease Mch-6
CASP-9
ICE-LAP6
ICE-like apoptotic protease 6
Reaction catalysed
Strict requirement for an Asp residue at position P1 and with a marked preference for His at position P2. It has a preferred cleavage sequence of Leu-Gly-His-Asp-|-Xaa
Comment(s)
  • Caspase-9 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63).
  • Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
  • An alternatively spliced version of caspase-9 also exists, caspase- 9S, that inhibits apoptosis, similar to the situation found with caspase-2.
  • Phosphorylation of caspase-9 from some species by Akt, a serine- threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo.
  • The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage.
  • Procaspase-3 is the enzyme's physiological substrate.
  • Belongs to peptidase family C14.
Cross-references
BRENDA3.4.22.62
EC2PDB3.4.22.62
ExplorEnz3.4.22.62
PRIAM enzyme-specific profiles3.4.22.62
KEGG Ligand Database for Enzyme Nomenclature3.4.22.62
IUBMB Enzyme Nomenclature3.4.22.62
IntEnz3.4.22.62
MEDLINEFind literature relating to 3.4.22.62
MetaCyc3.4.22.62
Rhea expert-curated reactions3.4.22.62
UniProtKB/Swiss-Prot
P55211, CASP9_HUMANQ8C3Q9, CASP9_MOUSE

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