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ENZYME entry: EC 4.1.1.107

Accepted Name
3,4-dihydroxyphenylacetaldehyde synthase.
Reaction catalysed
L-dopa + O(2) + H(2)O <=> 3,4-dihydroxyphenylacetaldehyde + CO(2) + NH(3) + H(2)O(2)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme, isolated from the mosquito Aedes aegypti, catalyzes the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa.
  • Dopamine is not formed as an intermediate (cf. EC 4.1.1.28).
  • The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha- methyl-L-dopa.
Cross-references
BRENDA4.1.1.107
EC2PDB4.1.1.107
ExplorEnz4.1.1.107
PRIAM enzyme-specific profiles4.1.1.107
KEGG Ligand Database for Enzyme Nomenclature4.1.1.107
IUBMB Enzyme Nomenclature4.1.1.107
IntEnz4.1.1.107
MEDLINEFind literature relating to 4.1.1.107
MetaCyc4.1.1.107
UniProtKB/Swiss-Prot
O96569, DHAPP_DROLE;  P18486, DHAPP_DROME;  P81893, DHAPP_DROSI;  
Q16S21, DHPAA_AEDAE;  Q06086, HPAAS_PETCR;  Q8RY79, PAAS_ARATH;  

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