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ENZYME

ENZYME entry: EC 4.1.1.107

PURL: https://purl.expasy.org/enzyme/EC/4.1.1.107
Accepted Name
3,4-dihydroxyphenylacetaldehyde synthase
Reaction catalysed
L-dopa + O2 + H2O + H(+) = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) + CO2
Comment(s)
  • The enzyme, isolated from the mosquito Aedes aegypti, catalyzes the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa.
  • Dopamine is not formed as an intermediate (cf. EC 4.1.1.28).
  • The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha- methyl-L-dopa.
Cross-references
BRENDA4.1.1.107
EC2PDB4.1.1.107
ExplorEnz4.1.1.107
KEGG Ligand Database for Enzyme Nomenclature4.1.1.107
IUBMB Enzyme Nomenclature4.1.1.107
MEDLINEFind literature relating to 4.1.1.107
MetaCyc4.1.1.107
Rhea expert-curated reactions4.1.1.107
UniProtKB/Swiss-Prot
O96569, DHAPP_DROLEP18486, DHAPP_DROMEP81893, DHAPP_DROSI
Q16S21, DHPAA_AEDAEQ06086, HPAAS_PETCRQ8RY79, PAAS_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
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