ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.1.1.107

Accepted Name
3,4-dihydroxyphenylacetaldehyde synthase.
Reaction catalysed
L-dopa + O(2) + H(2)O <=> 3,4-dihydroxyphenylacetaldehyde + CO(2) + NH(3) + H(2)O(2)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
The enzyme, isolated from the mosquito Aedes aegypti, catalyzes the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha- methyl-L-dopa.
Cross-references
BRENDA	4.1.1.107
EC2PDB	4.1.1.107
ExplorEnz	4.1.1.107
PRIAM enzyme-specific profiles	4.1.1.107
KEGG Ligand Database for Enzyme Nomenclature	4.1.1.107
IUBMB Enzyme Nomenclature	4.1.1.107
IntEnz	4.1.1.107
MEDLINE	Find literature relating to 4.1.1.107
MetaCyc	4.1.1.107

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