A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.2.43
| Accepted Name |
|---|
| 3-hexulose-6-phosphate synthase.
|
| Alternative Name(s) |
|---|
| 3-hexulose phosphate synthase. |
| 3-hexulosephosphate synthase. |
| D-arabino-3-hexulose 6-phosphate formaldehyde-lyase. |
| HPS. |
| Reaction catalysed |
|---|
| D-arabino-hex-3-ulose 6-phosphate <=> D-ribulose 5-phosphate + formaldehyde |
| Cofactor(s) |
|---|
| Mn(2+) or Mg(2+).
|
| Comment(s) |
|---|
- Specific for formaldehyde and D-ribulose 5-phosphate as substrates.
- Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and
fructose 6-phosphate cannot act as substrate.
- This enzyme, along with EC 5.3.1.27, plays a key role in the
ribulose-monophosphate cycle of formaldehyde fixation, which is
present in many microorganisms that are capable of utilizing
C1-compounds.
- The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii
OT3 constitutively produces a bifunctional enzyme that sequentially
catalyzes the reactions of this enzyme and EC 5.3.1.27.
|
| Cross-references |
|---|
| BRENDA | 4.1.2.43 |
| EC2PDB | 4.1.2.43 |
| ExplorEnz | 4.1.2.43 |
| PRIAM enzyme-specific profiles | 4.1.2.43 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.43 |
| IUBMB Enzyme Nomenclature | 4.1.2.43 |
| IntEnz | 4.1.2.43 |
| MEDLINE | Find literature relating to 4.1.2.43 |
| MetaCyc | 4.1.2.43 |
| UniProtKB/Swiss-Prot |
| O28964, FAEHP_ARCFU; | Q8THA9, FAEHP_METAC; | Q0W644, FAEHP_METAR; |
| A7I6C9, FAEHP_METB6; | Q46DY5, FAEHP_METBF; | Q12UK3, FAEHP_METBU; |
| Q2FQ74, FAEHP_METHJ; | Q58842, FAEHP_METJA; | Q8PXE1, FAEHP_METMA; |
| A3CUG8, FAEHP_METMJ; | B8GGX9, FAEHP_METPE; | Q2NE86, FAEHP_METST; |
| O27518, FAEHP_METTH; | A0B7U9, FAEHP_METTP; | Q49WT7, HPS1_STAS1; |
| Q49WT0, HPS2_STAS1; | Q49VB7, HPS3_STAS1; | P42405, HPS_BACSU; |
| Q48907, HPS_METAM; | Q46DA4, HPS_METBF; | Q9LBW4, HPS_MYCGS; |
| Q2FJ70, HPS_STAA3; | Q2G0K7, HPS_STAA8; | Q2YS94, HPS_STAAB; |
| Q5HIA5, HPS_STAAC; | Q99W39, HPS_STAAM; | Q7A774, HPS_STAAN; |
| Q6GJ99, HPS_STAAR; | Q6GBR7, HPS_STAAS; | Q8NXX1, HPS_STAAW; |
| Q5HRH7, HPS_STAEQ; | Q8CQ69, HPS_STAES; | Q4L3P8, HPS_STAHJ; |
|
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