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ENZYME

ENZYME entry: EC 4.1.2.43

PURL: https://purl.expasy.org/enzyme/EC/4.1.2.43
Accepted Name
3-hexulose-6-phosphate synthase
Alternative Name(s)
3-hexulosephosphate synthase
3-hexulose phosphate synthase
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase
HPS
Reaction catalysed
D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate
Comment(s)
  • Specific for formaldehyde and D-ribulose 5-phosphate as substrates.
  • Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate.
  • This enzyme, along with EC 5.3.1.27, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds.
  • The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of this enzyme and EC 5.3.1.27.
Cross-references
BRENDA4.1.2.43
EC2PDB4.1.2.43
ExplorEnz4.1.2.43
KEGG Ligand Database for Enzyme Nomenclature4.1.2.43
IUBMB Enzyme Nomenclature4.1.2.43
MEDLINEFind literature relating to 4.1.2.43
MetaCyc4.1.2.43
Rhea expert-curated reactions4.1.2.43
UniProtKB/Swiss-Prot
O28964, FAEHP_ARCFUQ8THA9, FAEHP_METACQ0W644, FAEHP_METAR
A7I6C9, FAEHP_METB6Q46DY5, FAEHP_METBFQ12UK3, FAEHP_METBU
Q2FQ74, FAEHP_METHJQ58842, FAEHP_METJAQ8PXE1, FAEHP_METMA
A3CUG8, FAEHP_METMJB8GGX9, FAEHP_METPEQ2NE86, FAEHP_METST
O27518, FAEHP_METTHA0B7U9, FAEHP_METTPQ49WT7, HPS1_STAS1
Q49WT0, HPS2_STAS1Q49VB7, HPS3_STAS1P42405, HPS_BACSU
Q48907, HPS_METAMQ46DA4, HPS_METBFQ9LBW4, HPS_MYCGS
Q2FJ70, HPS_STAA3Q2G0K7, HPS_STAA8Q2YS94, HPS_STAAB
Q5HIA5, HPS_STAACQ99W39, HPS_STAAMQ7A774, HPS_STAAN
Q6GJ99, HPS_STAARQ6GBR7, HPS_STAASQ8NXX1, HPS_STAAW
Q5HRH7, HPS_STAEQQ8CQ69, HPS_STAESQ4L3P8, HPS_STAHJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-