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ENZYME

ENZYME entry: EC 4.1.2.51

Accepted Name
2-dehydro-3-deoxy-D-gluconate aldolase
Alternative Name(s)
KDG-specific aldolase
Reaction catalysed
2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate
Comment(s)
  • The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway.
  • In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio.
  • It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14.
Cross-references
BRENDA4.1.2.51
EC2PDB4.1.2.51
ExplorEnz4.1.2.51
PRIAM enzyme-specific profiles4.1.2.51
KEGG Ligand Database for Enzyme Nomenclature4.1.2.51
IUBMB Enzyme Nomenclature4.1.2.51
IntEnz4.1.2.51
MEDLINEFind literature relating to 4.1.2.51
MetaCyc4.1.2.51
Rhea expert-curated reactions4.1.2.51
UniProtKB/Swiss-Prot
Q6KZI8, KDGA_PICTOQ704D1, KDGA_THETEP75682, YAGE_ECOLI

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