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ENZYME entry: EC 4.1.2.55

Accepted Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase.
Alternative Name(s)
2-keto-3-deoxygluconate aldolase.
Reaction catalysed
  • 2-dehydro-3-deoxy-6-phospho-D-gluconate <=> pyruvate + D-glyceraldehyde 3-phosphate
  • 2-dehydro-3-deoxy-6-phospho-D-galactonate <=> pyruvate + D-glyceraldehyde 3-phosphate
Comment(s)
  • In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway.
  • It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro- 3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency.
  • In vitro the enzyme can also catalyze the cleavage of the non- phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with much lower catalytic efficiency.
  • Cf. EC 4.1.2.21 and EC 4.1.2.14.
Cross-references
BRENDA4.1.2.55
EC2PDB4.1.2.55
ExplorEnz4.1.2.55
PRIAM enzyme-specific profiles4.1.2.55
KEGG Ligand Database for Enzyme Nomenclature4.1.2.55
IUBMB Enzyme Nomenclature4.1.2.55
IntEnz4.1.2.55
MEDLINEFind literature relating to 4.1.2.55
MetaCyc4.1.2.55
Rhea expert-curated reactions4.1.2.55
UniProtKB/Swiss-Prot
Q97U28, KDGA_SACS2;  O54288, KDGA_SACSO;  Q4JC35, KDGA_SULAC;  
F9VPG1, KDGA_SULTO;  

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