ENZYME entry: EC 4.1.2.55
Accepted Name |
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate
aldolase.
|
Alternative Name(s) |
2-keto-3-deoxygluconate aldolase. |
Reaction catalysed |
- 2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate
- 2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate
|
Comment(s) |
- In the archaeon Sulfolobus solfataricus the enzyme is involved in
glucose and galactose catabolism via the branched variant of the
Entner-Doudoroff pathway.
- It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-
3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency.
- In vitro the enzyme can also catalyze the cleavage of the non-
phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-
deoxy-D-galactonate with much lower catalytic efficiency.
- Cf. EC 4.1.2.21 and EC 4.1.2.14.
|
Cross-references |
BRENDA | 4.1.2.55 |
EC2PDB | 4.1.2.55 |
ExplorEnz | 4.1.2.55 |
PRIAM enzyme-specific profiles | 4.1.2.55 |
KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.55 |
IUBMB Enzyme Nomenclature | 4.1.2.55 |
IntEnz | 4.1.2.55 |
MEDLINE | Find literature relating to 4.1.2.55 |
MetaCyc | 4.1.2.55 |
Rhea expert-curated reactions | 4.1.2.55 |
UniProtKB/Swiss-Prot |
|
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