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ENZYME

ENZYME entry: EC 4.1.2.60

PURL: https://purl.expasy.org/enzyme/EC/4.1.2.60
Accepted Name
dihydroneopterin triphosphate aldolase
Reaction catalysed
7,8-dihydroneopterin 3'-triphosphate = glycolaldehyde triphosphate + 6-hydroxymethyl-7,8-dihydropterin
Comment(s)
  • The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla.
  • It provides a bypass mechanism compensating for the lack of EC 4.1.2.25.
  • In the malaria parasite Plasmodium falciparum the enzyme is bifunctional and also catalyzes the activity of EC 4.2.3.12. cf. EC 4.1.2.59.
Cross-references
BRENDA4.1.2.60
EC2PDB4.1.2.60
ExplorEnz4.1.2.60
KEGG Ligand Database for Enzyme Nomenclature4.1.2.60
IUBMB Enzyme Nomenclature4.1.2.60
MEDLINEFind literature relating to 4.1.2.60
MetaCyc4.1.2.60
Rhea expert-curated reactions4.1.2.60

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-