A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.2.8
| Accepted Name |
|---|
| Indole-3-glycerol-phosphate lyase.
|
| Alternative Name(s) |
|---|
| (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-
phosphate-lyase. |
| Indole glycerol phosphate hydrolase. |
| Indole synthase. |
| Indole-3-glycerol phosphate lyase. |
| Indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase. |
| Indoleglycerolphosphate aldolase. |
| Tryptophan synthase alpha. |
| TSA. |
| Reaction catalysed |
|---|
| (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> indole + D-glyceraldehyde 3-phosphate |
| Comment(s) |
|---|
- Forms part of the defense mechanism against insects and microbial
pathogens in the grass family, Gramineae, where it catalyzes one of
the steps in the formation of the cyclic hydroxamic acids 2,4-
dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-
methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA).
- Resembles the alpha-subunit of EC 4.2.1.20 but, unlike tryptophan
synthase, its activity is independent of the beta-subunit and free
indole is released.
|
| Cross-references |
|---|
| PROSITE | PDOC00151 |
| BRENDA | 4.1.2.8 |
| EC2PDB | 4.1.2.8 |
| ExplorEnz | 4.1.2.8 |
| PRIAM enzyme-specific profiles | 4.1.2.8 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.8 |
| IUBMB Enzyme Nomenclature | 4.1.2.8 |
| IntEnz | 4.1.2.8 |
| MEDLINE | Find literature relating to 4.1.2.8 |
| MetaCyc | 4.1.2.8 |
| UniProtKB/Swiss-Prot |
|
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