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ENZYME entry: EC 4.1.2.8

Accepted Name
indole-3-glycerol-phosphate lyase.
Alternative Name(s)
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3- phosphate-lyase.
indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase.
indole-3-glycerol phosphate lyase.
indoleglycerolphosphate aldolase.
indole glycerol phosphate hydrolase.
indole synthase.
tryptophan synthase alpha.
TSA.
Reaction catalysed
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole
Comment(s)
  • Forms part of the defense mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyzes one of the steps in the formation of the cyclic hydroxamic acids 2,4- dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA).
  • Resembles the alpha-subunit of EC 4.2.1.20 but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released.
Cross-references
BRENDA4.1.2.8
EC2PDB4.1.2.8
ExplorEnz4.1.2.8
PRIAM enzyme-specific profiles4.1.2.8
KEGG Ligand Database for Enzyme Nomenclature4.1.2.8
IUBMB Enzyme Nomenclature4.1.2.8
IntEnz4.1.2.8
MEDLINEFind literature relating to 4.1.2.8
MetaCyc4.1.2.8
Rhea expert-curated reactions4.1.2.8
UniProtKB/Swiss-Prot
O22765, TRPA1_ARATH;  Q42529, TRPA2_ARATH;  P42390, TRPA_MAIZE;  

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