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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Indole-3-glycerol-phosphate lyase.
Alternative Name(s)
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3- phosphate-lyase.
Indole glycerol phosphate hydrolase.
Indole synthase.
Indole-3-glycerol phosphate lyase.
Indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase.
Indoleglycerolphosphate aldolase.
Tryptophan synthase alpha.
Reaction catalysed
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> indole + D-glyceraldehyde 3-phosphate
  • Forms part of the defense mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyzes one of the steps in the formation of the cyclic hydroxamic acids 2,4- dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA).
  • Resembles the alpha-subunit of EC but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released.
PRIAM enzyme-specific profiles4.1.2.8
KEGG Ligand Database for Enzyme Nomenclature4.1.2.8
IUBMB Enzyme Nomenclature4.1.2.8
MEDLINEFind literature relating to
O22765, TRPA1_ARATH;  Q42529, TRPA2_ARATH;  P42390, TRPA_MAIZE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-