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ENZYME entry: EC 4.2.1.20

Accepted Name
Tryptophan synthase.
Alternative Name(s)
Indoleglycerol phosphate aldolase.
L-tryptophan synthetase.
Tryptophan desmolase.
Tryptophan synthetase.
Reaction catalysed
L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate <=> L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The alpha-subunit catalyzes the conversion of 1-C-(indol-3- yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was listed formerly as EC 4.1.2.8).
  • The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan.
  • In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 5.3.1.24.
  • In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the beta subunit can be found (EC 4.2.1.122).
  • That enzyme cannot combine with the alpha unit of EC 4.2.1.20 to form a complex.
Cross-references
PROSITEPDOC00151 ; PDOC00152
BRENDA4.2.1.20
EC2PDB4.2.1.20
ExplorEnz4.2.1.20
PRIAM enzyme-specific profiles4.2.1.20
KEGG Ligand Database for Enzyme Nomenclature4.2.1.20
IUBMB Enzyme Nomenclature4.2.1.20
IntEnz4.2.1.20
MEDLINEFind literature relating to 4.2.1.20
MetaCyc4.2.1.20
Rhea expert-curated reactions4.2.1.20
UniProtKB/Swiss-Prot
P25269, TRBP2_ARATH;  O22765, TRPA1_ARATH;  Q9TLW8, TRPA1_CYACA;  
Q42529, TRPA2_ARATH;  P34793, TRPA2_CYACA;  B0C6F8, TRPA_ACAM1;  
Q6FEE6, TRPA_ACIAD;  B7GWQ5, TRPA_ACIB3;  B7I8K2, TRPA_ACIB5;  
B2HYJ0, TRPA_ACIBC;  B0VRF8, TRPA_ACIBS;  A3M8N2, TRPA_ACIBT;  
B0V529, TRPA_ACIBY;  A0LTT7, TRPA_ACIC1;  A5FY58, TRPA_ACICJ;  
B9MDL9, TRPA_ACIET;  B7J4S8, TRPA_ACIF2;  B5EK17, TRPA_ACIF5;  
A1WAT8, TRPA_ACISJ;  A3MZI8, TRPA_ACTP2;  B3GX47, TRPA_ACTP7;  
B0BU73, TRPA_ACTPJ;  A6VPE0, TRPA_ACTSZ;  A0KMD1, TRPA_AERHH;  
Q9Y8T3, TRPA_AERPE;  A4SKT0, TRPA_AERS4;  B6JCP3, TRPA_AFIC5;  
Q8UJA9, TRPA_AGRFC;  B9JG44, TRPA_AGRRK;  B9JXV7, TRPA_AGRVS;  
Q0VPJ0, TRPA_ALCBS;  Q5E624, TRPA_ALIF1;  B5FDB6, TRPA_ALIFM;  
B6EJA2, TRPA_ALISL;  Q0A9A1, TRPA_ALKEH;  Q9KCA9, TRPA_ALKHC;  
A6TM77, TRPA_ALKMQ;  P31204, TRPA_ANTSP;  O67502, TRPA_AQUAE;  
O28673, TRPA_ARCFU;  Q5P1I9, TRPA_AROAE;  Q9LAG8, TRPA_AZOBR;  
A8HQ60, TRPA_AZOC5;  B6YR34, TRPA_AZOPC;  A1K4B0, TRPA_AZOSB;  
C1DH67, TRPA_AZOVD;  C3P3U1, TRPA_BACAA;  C3LAV7, TRPA_BACAC;  
A0RB65, TRPA_BACAH;  Q81TL7, TRPA_BACAN;  B7JET1, TRPA_BACC0;  
Q73BQ6, TRPA_BACC1;  B7IM77, TRPA_BACC2;  C1ELF1, TRPA_BACC3;  
B7HH02, TRPA_BACC4;  B7I0F3, TRPA_BACC7;  Q81GG4, TRPA_BACCR;  
Q63EC6, TRPA_BACCZ;  Q5LBZ2, TRPA_BACFN;  Q64SX3, TRPA_BACFR;  
Q6HLU3, TRPA_BACHK;  Q65I36, TRPA_BACLD;  A9VJW3, TRPA_BACMK;  
Q8KZ93, TRPA_BACNA;  A8FEJ7, TRPA_BACP2;  Q5WGS0, TRPA_BACSK;  
P07601, TRPA_BACSU;  Q8AAD8, TRPA_BACTN;  A7Z615, TRPA_BACVZ;  
B2IF46, TRPA_BEII9;  Q8G691, TRPA_BIFLO;  Q7VQZ9, TRPA_BLOFL;  
Q7WD05, TRPA_BORBR;  Q7W5G9, TRPA_BORPA;  Q7VTF0, TRPA_BORPE;  
Q89WE4, TRPA_BRADU;  A4YJI5, TRPA_BRASO;  B2S9A3, TRPA_BRUA1;  
Q2YQW7, TRPA_BRUA2;  A6WX30, TRPA_BRUA4;  Q57AF2, TRPA_BRUAB;  
A9M9U0, TRPA_BRUC2;  C0RFZ2, TRPA_BRUMB;  Q8YE59, TRPA_BRUME;  
A5VT61, TRPA_BRUO2;  B0CJK6, TRPA_BRUSI;  Q8FXY6, TRPA_BRUSU;  
B8D970, TRPA_BUCA5;  P57365, TRPA_BUCAI;  P42389, TRPA_BUCAP;  
B8D7H4, TRPA_BUCAT;  P59457, TRPA_BUCBP;  O68429, TRPA_BUCDN;  
Q9RQ33, TRPA_BUCMH;  Q44604, TRPA_BUCSC;  B1Z1P1, TRPA_BURA4;  
Q1BM66, TRPA_BURCA;  B1K366, TRPA_BURCC;  A0AZ71, TRPA_BURCH;  
B4EFK2, TRPA_BURCJ;  Q393Y2, TRPA_BURL3;  A9AMA5, TRPA_BURM1;  
A3MBU6, TRPA_BURM7;  A2S138, TRPA_BURM9;  Q62AJ6, TRPA_BURMA;  
A1UZ42, TRPA_BURMS;  A3P7M8, TRPA_BURP0;  A3NM66, TRPA_BURP6;  
Q63JM0, TRPA_BURPS;  Q2T7G9, TRPA_BURTA;  B9MKC6, TRPA_CALBD;  
Q8R9N0, TRPA_CALS4;  A4XLM3, TRPA_CALS8;  A8FKD8, TRPA_CAMJ8;  
A7H522, TRPA_CAMJD;  Q9PIF1, TRPA_CAMJE;  A1VY70, TRPA_CAMJJ;  
Q5HWB8, TRPA_CAMJR;  Q3ABS4, TRPA_CARHZ;  B0T694, TRPA_CAUSK;  
P12291, TRPA_CAUVC;  B8H661, TRPA_CAUVN;  Q9X4E8, TRPA_CERS4;  
A4WPE1, TRPA_CERS5;  A9WFI5, TRPA_CHLAA;  B8G5G4, TRPA_CHLAD;  
Q3AR00, TRPA_CHLCH;  Q822W2, TRPA_CHLCV;  Q254T1, TRPA_CHLFF;  
B3EGF7, TRPA_CHLL2;  Q3B5F2, TRPA_CHLL3;  B3QPB1, TRPA_CHLP8;  
B3ENW0, TRPA_CHLPB;  A1BHS2, TRPA_CHLPD;  A4SDQ2, TRPA_CHLPM;  
B9LKB2, TRPA_CHLSY;  Q8KEZ7, TRPA_CHLTE;  O84173, TRPA_CHLTR;  
Q1QY41, TRPA_CHRSD;  Q7NUD9, TRPA_CHRVO;  B5EAK6, TRPA_CITBB;  
A8AG60, TRPA_CITK8;  Q97EF6, TRPA_CLOAB;  A6LU97, TRPA_CLOB8;  
B9E152, TRPA_CLOK1;  A5N7P1, TRPA_CLOK5;  C3PKY7, TRPA_CORA7;  
Q6NEB5, TRPA_CORDI;  Q8FLJ5, TRPA_COREF;  A4QI77, TRPA_CORGB;  
P06562, TRPA_CORGL;  B1VH82, TRPA_CORU7;  B6J7I2, TRPA_COXB1;  
A9KE95, TRPA_COXBN;  A9NDN6, TRPA_COXBR;  Q83CG2, TRPA_COXBU;  
B1WNQ1, TRPA_CROS5;  A7MMG7, TRPA_CROS8;  Q1LKI4, TRPA_CUPMC;  
Q46YW7, TRPA_CUPPJ;  B3R113, TRPA_CUPTR;  O22018, TRPA_CYAM1;  
B8HPH2, TRPA_CYAP4;  Q47HQ4, TRPA_DECAR;  Q3Z6G1, TRPA_DEHM1;  
A5FPL3, TRPA_DEHMB;  Q3ZZ10, TRPA_DEHMC;  Q9RVT0, TRPA_DEIRA;  
A9BNH8, TRPA_DELAS;  C0QMA1, TRPA_DESAH;  B8FA37, TRPA_DESAL;  
B8J160, TRPA_DESDA;  C4XI54, TRPA_DESMR;  A8ZZW7, TRPA_DESOH;  
Q6AMR6, TRPA_DESPS;  Q72EU7, TRPA_DESVH;  A1VGB6, TRPA_DESVV;  
B5YD09, TRPA_DICT6;  B8DZP8, TRPA_DICTD;  A7ZL78, TRPA_ECO24;  
B7UR66, TRPA_ECO27;  B7ML76, TRPA_ECO45;  B7L492, TRPA_ECO55;  
Q8X7B5, TRPA_ECO57;  B5YZP0, TRPA_ECO5E;  B7NVN0, TRPA_ECO7I;  
B7MU99, TRPA_ECO81;  B7LY16, TRPA_ECO8A;  C4ZTV3, TRPA_ECOBW;  
B1XBK9, TRPA_ECODH;  A7ZZJ6, TRPA_ECOHS;  A1AAN0, TRPA_ECOK1;  
Q0TIB0, TRPA_ECOL5;  Q8FHW0, TRPA_ECOL6;  B1ITJ5, TRPA_ECOLC;  
P0A877, TRPA_ECOLI;  B7N473, TRPA_ECOLU;  B6I9X4, TRPA_ECOSE;  
B1LH32, TRPA_ECOSM;  Q1RCA7, TRPA_ECOUT;  C5BDB6, TRPA_EDWI9;  
A4WB03, TRPA_ENT38;  B2VKT1, TRPA_ERWT9;  Q2N9N0, TRPA_ERYLH;  
B7LS20, TRPA_ESCF3;  A5FA76, TRPA_FLAJ1;  A6GWZ0, TRPA_FLAPJ;  
Q14FN3, TRPA_FRAT1;  A7N9D1, TRPA_FRATF;  Q2A5V4, TRPA_FRATH;  
B2SEK8, TRPA_FRATM;  Q0BP46, TRPA_FRATO;  Q5NE80, TRPA_FRATT;  
A4IVS5, TRPA_FRATW;  B9M7D5, TRPA_GEODF;  Q5KXV2, TRPA_GEOKA;  
Q39SS2, TRPA_GEOMG;  P19867, TRPA_GEOSE;  Q74AI3, TRPA_GEOSL;  
C6E1P3, TRPA_GEOSM;  C5D3D3, TRPA_GEOSW;  A4IQ81, TRPA_GEOTN;  
A5G6M1, TRPA_GEOUR;  Q7NHC5, TRPA_GLOVI;  A9HE84, TRPA_GLUDA;  
Q5FRN3, TRPA_GLUOX;  Q0BQJ0, TRPA_GRABC;  A0M4T5, TRPA_GRAFK;  
Q6B8L2, TRPA_GRATL;  Q4QKF6, TRPA_HAEI8;  A5UC41, TRPA_HAEIE;  
A5UEU6, TRPA_HAEIG;  P43759, TRPA_HAEIN;  A1WY05, TRPA_HALHL;  
Q5V140, TRPA_HALMA;  B0R333, TRPA_HALS3;  Q9HSB9, TRPA_HALSA;  
P18284, TRPA_HALVD;  Q7VGA8, TRPA_HELHP;  B6JNB7, TRPA_HELP2;  
B5Z8S2, TRPA_HELPG;  Q1CRX0, TRPA_HELPH;  Q9ZJV0, TRPA_HELPJ;  
B2UV41, TRPA_HELPS;  P56141, TRPA_HELPY;  A9B6M7, TRPA_HERA2;  
A4G4G3, TRPA_HERAR;  B0UU33, TRPA_HISS2;  Q31HH3, TRPA_HYDCU;  
Q5QX79, TRPA_IDILO;  A6T006, TRPA_JANMA;  Q28LB1, TRPA_JANSC;  
P00930, TRPA_KLEAE;  B5XT03, TRPA_KLEP3;  A6T7W5, TRPA_KLEP7;  
P17166, TRPA_LACCA;  C4Z135, TRPA_LACE2;  Q01997, TRPA_LACLA;  
A2RK25, TRPA_LACLM;  Q02YB8, TRPA_LACLS;  Q88WH9, TRPA_LACPL;  
C1D702, TRPA_LARHH;  Q5X5Q1, TRPA_LEGPA;  A5IBF8, TRPA_LEGPC;  
Q5ZVY3, TRPA_LEGPH;  Q5WX31, TRPA_LEGPL;  Q6AF66, TRPA_LEIXX;  
B0SDM7, TRPA_LEPBA;  Q04U62, TRPA_LEPBJ;  Q053M5, TRPA_LEPBL;  
Q5MI53, TRPA_LEPBP;  B1XY49, TRPA_LEPCP;  Q72U04, TRPA_LEPIC;  
Q8F150, TRPA_LEPIN;  Q92B82, TRPA_LISIN;  C1KVS4, TRPA_LISMC;  
Q71Z41, TRPA_LISMF;  B8DHB5, TRPA_LISMH;  Q8Y6Q7, TRPA_LISMO;  
A0AJ79, TRPA_LISW6;  Q2W010, TRPA_MAGSA;  P42390, TRPA_MAIZE;  
Q65TE9, TRPA_MANSM;  A1U0X2, TRPA_MARN8;  C6C1D1, TRPA_MARSD;  
Q8TLP4, TRPA_METAC;  A7I4T3, TRPA_METB6;  Q465F4, TRPA_METBF;  
B7KSK7, TRPA_METC4;  Q604P4, TRPA_METCA;  A9VWE9, TRPA_METEP;  
Q60180, TRPA_METJA;  Q8TYA2, TRPA_METKA;  A4FXH7, TRPA_METM5;  
A9AAU6, TRPA_METM6;  A6VFT8, TRPA_METM7;  Q8PT96, TRPA_METMA;  
Q6LYI9, TRPA_METMP;  B8IPW1, TRPA_METNO;  B1ZLY7, TRPA_METPB;  
A2SHS3, TRPA_METPP;  B1LSQ8, TRPA_METRJ;  B0UKV2, TRPA_METS4;  
O27697, TRPA_METTH;  P26920, TRPA_METTM;  P14637, TRPA_METVO;  
A6UP14, TRPA_METVS;  B0JXU3, TRPA_MICAN;  A0QHG8, TRPA_MYCA1;  
B1MBV2, TRPA_MYCA9;  P66981, TRPA_MYCBO;  A1KJ29, TRPA_MYCBP;  
C1ANN5, TRPA_MYCBT;  O68906, TRPA_MYCIT;  B8ZRC1, TRPA_MYCLB;  
Q9CC53, TRPA_MYCLE;  B2HQX9, TRPA_MYCMM;  Q740P2, TRPA_MYCPA;  
A5U2W9, TRPA_MYCTA;  P9WFY0, TRPA_MYCTO;  P9WFY1, TRPA_MYCTU;  
A0PP30, TRPA_MYCUA;  Q3IQC4, TRPA_NATPD;  Q5F9Y6, TRPA_NEIG1;  
Q9JVE0, TRPA_NEIMA;  Q9K0D4, TRPA_NEIMB;  Q1XDA5, TRPA_NEOYE;  
Q82WI1, TRPA_NITEU;  Q1QS34, TRPA_NITHX;  Q2Y7R5, TRPA_NITMU;  
Q3JCB7, TRPA_NITOC;  Q3SWL9, TRPA_NITWN;  Q5YYN3, TRPA_NOCFA;  
Q2G8S8, TRPA_NOVAD;  Q8ESU5, TRPA_OCEIH;  B1ZT49, TRPA_OPITP;  
A6L9J8, TRPA_PARD8;  A1AYV3, TRPA_PARDP;  Q7TTU8, TRPA_PARMW;  
B2JQF0, TRPA_PARP8;  B2T9N0, TRPA_PARPJ;  P57854, TRPA_PASMU;  
Q6D4T9, TRPA_PECAS;  C6DGZ4, TRPA_PECCP;  B4SEN7, TRPA_PELPB;  
A1AN65, TRPA_PELPD;  Q4FND0, TRPA_PELUB;  A9BHQ2, TRPA_PETMO;  
B4RCL1, TRPA_PHEZH;  Q7N485, TRPA_PHOLL;  Q6LPA3, TRPA_PHOPR;  
A6L7N1, TRPA_PHOV8;  A4SWX7, TRPA_POLAQ;  A1VRR8, TRPA_POLNA;  
B1XV46, TRPA_POLNS;  Q126M0, TRPA_POLSJ;  P51382, TRPA_PORPU;  
B4S6H5, TRPA_PROA2;  A2C129, TRPA_PROM1;  Q7VD15, TRPA_PROMA;  
B4EWH8, TRPA_PROMH;  Q7TV26, TRPA_PROMM;  Q7TUC8, TRPA_PROMP;  
Q46LX8, TRPA_PROMT;  Q48QG7, TRPA_PSE14;  A6UX98, TRPA_PSEA7;  
B7V0S0, TRPA_PSEA8;  Q02V45, TRPA_PSEAB;  P07344, TRPA_PSEAE;  
Q1IH21, TRPA_PSEE4;  Q4KKP5, TRPA_PSEF5;  C3K568, TRPA_PSEFS;  
A4XNC8, TRPA_PSEMY;  A5VWL2, TRPA_PSEP1;  Q3KK58, TRPA_PSEPF;  
B0KFW2, TRPA_PSEPG;  Q88RP7, TRPA_PSEPK;  P11081, TRPA_PSEPU;  
B1J4B0, TRPA_PSEPW;  Q88B60, TRPA_PSESM;  P34816, TRPA_PSESY;  
Q500R5, TRPA_PSEU2;  A4VNJ1, TRPA_PSEU5;  Q4FUL2, TRPA_PSYA2;  
Q1QDK2, TRPA_PSYCK;  A5WDG7, TRPA_PSYWF;  Q9V1G9, TRPA_PYRAB;  
Q8U094, TRPA_PYRFU;  B2U6Y7, TRPA_RALPJ;  Q8XXY2, TRPA_RALSO;  
B3PVV3, TRPA_RHIE6;  Q2KE81, TRPA_RHIEC;  Q1MND5, TRPA_RHIL3;  
Q98CN6, TRPA_RHILO;  B5ZV71, TRPA_RHILW;  Q92TC8, TRPA_RHIME;  
Q7URN0, TRPA_RHOBA;  Q21XI7, TRPA_RHOFT;  Q2J2G5, TRPA_RHOP2;  
Q07UH0, TRPA_RHOP5;  Q6NDN5, TRPA_RHOPA;  Q13EQ1, TRPA_RHOPS;  
B3Q606, TRPA_RHOPT;  A3PMM5, TRPA_RHOS1;  B9KMG7, TRPA_RHOSK;  
B7JUK2, TRPA_RIPO1;  A7NKL7, TRPA_ROSCS;  Q161I8, TRPA_ROSDO;  
A5UXG2, TRPA_ROSS1;  Q5LV87, TRPA_RUEPO;  A1AXS3, TRPA_RUTMC;  
P50382, TRPA_SACS2;  B5F4M3, TRPA_SALA4;  A8LX37, TRPA_SALAI;  
A9MPY6, TRPA_SALAR;  Q57NT2, TRPA_SALCH;  B5FU65, TRPA_SALDC;  
B5R3P3, TRPA_SALEP;  B5R6M4, TRPA_SALG2;  B4TJK9, TRPA_SALHS;  
B4T6X2, TRPA_SALNS;  Q5PNM0, TRPA_SALPA;  A9MWR3, TRPA_SALPB;  
C0Q3N3, TRPA_SALPC;  B5BIC0, TRPA_SALPK;  Q2S1Z2, TRPA_SALRD;  
B4TX39, TRPA_SALSV;  Q8Z7E0, TRPA_SALTI;  A4X9N0, TRPA_SALTO;  
P00929, TRPA_SALTY;  A8GF83, TRPA_SERP5;  A1S7I3, TRPA_SHEAM;  
A3D631, TRPA_SHEB5;  A6WPX2, TRPA_SHEB8;  A9KTR8, TRPA_SHEB9;  
Q8ECU9, TRPA_SHEON;  B2U0F1, TRPA_SHIB3;  Q31ZV3, TRPA_SHIBS;  
Q32GT0, TRPA_SHIDS;  Q0T5D6, TRPA_SHIF8;  P0A878, TRPA_SHIFL;  
Q3Z108, TRPA_SHISS;  C3MBA0, TRPA_SINFN;  A6UEI2, TRPA_SINMW;  
Q2NT53, TRPA_SODGM;  Q01NI9, TRPA_SOLUE;  A5V9W7, TRPA_SPHWW;  
A7X240, TRPA_STAA1;  A6U1J5, TRPA_STAA2;  Q2FH63, TRPA_STAA3;  
Q2FYR3, TRPA_STAA8;  A5ISQ5, TRPA_STAA9;  Q2YXZ6, TRPA_STAAB;  
Q5HG46, TRPA_STAAC;  A6QGS5, TRPA_STAAE;  P66982, TRPA_STAAM;  
P66983, TRPA_STAAN;  Q6GH32, TRPA_STAAR;  Q6G9I6, TRPA_STAAS;  
A8Z245, TRPA_STAAT;  Q8NWU1, TRPA_STAAW;  B9DP27, TRPA_STACT;  
Q5HPG9, TRPA_STAEQ;  Q8CPB0, TRPA_STAES;  Q4L680, TRPA_STAHJ;  
Q49XH9, TRPA_STAS1;  Q82A81, TRPA_STRAW;  O68816, TRPA_STRCO;  
A8AW06, TRPA_STRGC;  Q8DVF2, TRPA_STRMU;  Q04IZ0, TRPA_STRP2;  
B5E7M2, TRPA_STRP4;  C1C965, TRPA_STRP7;  B1I7S6, TRPA_STRPI;  
B8ZN58, TRPA_STRPJ;  Q97P33, TRPA_STRPN;  Q8DNM9, TRPA_STRR6;  
A3CLM2, TRPA_STRSV;  Q5LYI8, TRPA_STRT1;  Q5M351, TRPA_STRT2;  
Q03JC2, TRPA_STRTD;  C1CG41, TRPA_STRZJ;  C1CMD2, TRPA_STRZP;  
C1CT50, TRPA_STRZT;  Q4J8X8, TRPA_SULAC;  A8Z5Y2, TRPA_SULMW;  
Q971Z6, TRPA_SULTO;  Q67PJ3, TRPA_SYMTH;  Q2LUE0, TRPA_SYNAS;  
Q3A2C7, TRPA_SYNC1;  Q31R76, TRPA_SYNE7;  A0LJ55, TRPA_SYNFM;  
Q8KX32, TRPA_SYNP2;  Q5N324, TRPA_SYNP6;  Q3AYG5, TRPA_SYNS9;  
Q0B002, TRPA_SYNWW;  P77960, TRPA_SYNY3;  Q47QR3, TRPA_THEFY;  
Q9YGA9, TRPA_THEKO;  P50908, TRPA_THEMA;  B9K6Z6, TRPA_THENN;  
A5IKT4, TRPA_THEP1;  B0K8T7, TRPA_THEP3;  B0K2T8, TRPA_THEPX;  
B1LA15, TRPA_THESQ;  P16608, TRPA_THET2;  Q5SJC0, TRPA_THET8;  
Q8DLN9, TRPA_THEVB;  Q3SHM0, TRPA_THIDA;  B8GQE5, TRPA_THISH;  
C4LC88, TRPA_TOLAT;  Q10W95, TRPA_TRIEI;  Q3MBD2, TRPA_TRIV2;  
A1WSF0, TRPA_VEREI;  A5CVK4, TRPA_VESOH;  B7VGU8, TRPA_VIBA3;  
A5F207, TRPA_VIBC3;  Q9KST7, TRPA_VIBCH;  C3LLL5, TRPA_VIBCM;  
Q9RCE7, TRPA_VIBME;  P22095, TRPA_VIBPA;  Q8D8B1, TRPA_VIBVU;  
Q7MM57, TRPA_VIBVY;  Q7M877, TRPA_WOLSU;  Q8PJ29, TRPA_XANAC;  
Q3BRL7, TRPA_XANC5;  Q4UWD0, TRPA_XANC8;  B0RR86, TRPA_XANCB;  
Q8P7S0, TRPA_XANCP;  Q2P0U3, TRPA_XANOM;  B2SVN5, TRPA_XANOP;  
Q5GXR6, TRPA_XANOR;  B2I9J3, TRPA_XYLF2;  Q9PDK3, TRPA_XYLFA;  
B0U6K7, TRPA_XYLFM;  Q87DR8, TRPA_XYLFT;  A1JPY2, TRPA_YERE8;  
A7FI34, TRPA_YERP3;  Q1C7P3, TRPA_YERPA;  B2K3W1, TRPA_YERPB;  
Q8ZEH0, TRPA_YERPE;  A9R995, TRPA_YERPG;  Q1CJ29, TRPA_YERPN;  
A4TJ68, TRPA_YERPP;  Q66AK5, TRPA_YERPS;  B1JKS3, TRPA_YERPY;  
Q5NPZ7, TRPA_ZYMMO;  Q9Y8T5, TRPB1_AERPE;  O66923, TRPB1_AQUAE;  
P14671, TRPB1_ARATH;  O28672, TRPB1_ARCFU;  Q822W9, TRPB1_CHLCV;  
Q8FLJ6, TRPB1_COREF;  P43283, TRPB1_MAIZE;  Q8TLP3, TRPB1_METAC;  
Q8PT95, TRPB1_METMA;  O27696, TRPB1_METTH;  Q8YZP7, TRPB1_NOSS1;  
Q9V1G8, TRPB1_PYRAB;  Q8U093, TRPB1_PYRFU;  P50383, TRPB1_SACS2;  
Q971Z5, TRPB1_SULTO;  Q9YGB0, TRPB1_THEKO;  P50909, TRPB1_THEMA;  
P22097, TRPB1_VIBPA;  Q7M9S1, TRPB1_WOLSU;  Q9Y9H2, TRPB2_AERPE;  
O67409, TRPB2_AQUAE;  O29028, TRPB2_ARCFU;  Q822W3, TRPB2_CHLCV;  
Q8FT12, TRPB2_COREF;  P43284, TRPB2_MAIZE;  Q8TL44, TRPB2_METAC;  
Q8Q001, TRPB2_METMA;  O27520, TRPB2_METTH;  P26921, TRPB2_METTM;  
Q8YQM6, TRPB2_NOSS1;  Q9V150, TRPB2_PYRAB;  Q8U0J5, TRPB2_PYRFU;  
Q97TX6, TRPB2_SACS2;  Q970N1, TRPB2_SULTO;  Q5JDJ1, TRPB2_THEKO;  
Q9WZ09, TRPB2_THEMA;  Q87IM1, TRPB2_VIBPA;  Q7M8W7, TRPB2_WOLSU;  
A1TLG8, TRPB_ACIAC;  Q6FEF1, TRPB_ACIAD;  P16706, TRPB_ACICA;  
A5FY57, TRPB_ACICJ;  B7J4S9, TRPB_ACIF2;  B5EK18, TRPB_ACIF5;  
A3MZI7, TRPB_ACTP2;  B3GX46, TRPB_ACTP7;  B0BU72, TRPB_ACTPJ;  
A6VPD9, TRPB_ACTSZ;  A0KMD0, TRPB_AERHH;  A4SKT1, TRPB_AERS4;  
B6JCP2, TRPB_AFIC5;  Q8UJB0, TRPB_AGRFC;  B9JG43, TRPB_AGRRK;  
B9JXV6, TRPB_AGRVS;  Q5E623, TRPB_ALIF1;  B5FDB7, TRPB_ALIFM;  
B6EJA3, TRPB_ALISL;  Q9KCB0, TRPB_ALKHC;  A6TM76, TRPB_ALKMQ;  
B4S1J4, TRPB_ALTMD;  B7GHQ9, TRPB_ANOFW;  B6YQ32, TRPB_AZOPC;  
C1DH66, TRPB_AZOVD;  C3P3U0, TRPB_BACAA;  C3LAV8, TRPB_BACAC;  
A0RB64, TRPB_BACAH;  Q81TL8, TRPB_BACAN;  Q73BQ7, TRPB_BACC1;  
B7IM76, TRPB_BACC2;  C1ELF0, TRPB_BACC3;  B7HH01, TRPB_BACC4;  
B7I0F2, TRPB_BACC7;  B9IU38, TRPB_BACCQ;  Q81GG5, TRPB_BACCR;  
Q63EC7, TRPB_BACCZ;  Q5LBZ8, TRPB_BACFN;  Q64SX9, TRPB_BACFR;  
Q6HLU4, TRPB_BACHK;  Q65I35, TRPB_BACLD;  A9VJW2, TRPB_BACMK;  
A8FEJ8, TRPB_BACP2;  Q5WGS1, TRPB_BACSK;  P07600, TRPB_BACSU;  
Q8AAD2, TRPB_BACTN;  A7Z616, TRPB_BACVZ;  B2IF48, TRPB_BEII9;  
Q7VR00, TRPB_BLOFL;  Q492N6, TRPB_BLOPB;  Q7WD04, TRPB_BORBR;  
Q7W5G8, TRPB_BORPA;  A9IIE0, TRPB_BORPD;  Q7VTF1, TRPB_BORPE;  
Q89WE5, TRPB_BRADU;  A5E8A4, TRPB_BRASB;  A4YJI6, TRPB_BRASO;  
B2S9A5, TRPB_BRUA1;  Q2YQW5, TRPB_BRUA2;  A6WX28, TRPB_BRUA4;  
Q57AF0, TRPB_BRUAB;  A9M9U2, TRPB_BRUC2;  C0RFZ4, TRPB_BRUMB;  
Q8YE60, TRPB_BRUME;  B0CJK8, TRPB_BRUSI;  Q8FXY4, TRPB_BRUSU;  
Q44685, TRPB_BUCAI;  P42391, TRPB_BUCAP;  P59458, TRPB_BUCBP;  
O68428, TRPB_BUCDN;  Q44687, TRPB_BUCMH;  Q44686, TRPB_BUCRM;  
Q44688, TRPB_BUCRP;  Q59169, TRPB_BUCSC;  Q8R9M9, TRPB_CALS4;  
O50046, TRPB_CAMAC;  A8FKD7, TRPB_CAMJ8;  A7H523, TRPB_CAMJD;  
Q9PIF2, TRPB_CAMJE;  A1VY69, TRPB_CAMJJ;  Q5HWB9, TRPB_CAMJR;  
P12290, TRPB_CAUVC;  Q9X4E5, TRPB_CERS4;  Q11KK9, TRPB_CHESB;  
Q8KF11, TRPB_CHLTE;  O84172, TRPB_CHLTR;  Q7NUD8, TRPB_CHRVO;  
A8AG61, TRPB_CITK8;  A5CRV6, TRPB_CLAM3;  B0REU1, TRPB_CLAMS;  
Q97EF5, TRPB_CLOAB;  A6LU96, TRPB_CLOB8;  B2V2T4, TRPB_CLOBA;  
B2TM49, TRPB_CLOBB;  B9E151, TRPB_CLOK1;  A5N7P0, TRPB_CLOK5;  
A0PYH3, TRPB_CLONN;  A4QI76, TRPB_CORGB;  P06561, TRPB_CORGL;  
A7MMG1, TRPB_CROS8;  Q47HQ5, TRPB_DECAR;  Q9RVT1, TRPB_DEIRA;  
B8D4P0, TRPB_DESA1;  A8LSF9, TRPB_DINSH;  A7ZL79, TRPB_ECO24;  
B7UR67, TRPB_ECO27;  B7ML77, TRPB_ECO45;  B7L493, TRPB_ECO55;  
Q8X7B6, TRPB_ECO57;  B5YZP1, TRPB_ECO5E;  B7NVN1, TRPB_ECO7I;  
B7MUA0, TRPB_ECO81;  B7LY17, TRPB_ECO8A;  B1XBL0, TRPB_ECODH;  
A7ZZJ7, TRPB_ECOHS;  A1AAN1, TRPB_ECOK1;  Q0TIA9, TRPB_ECOL5;  
Q8FHV9, TRPB_ECOL6;  B1ITJ4, TRPB_ECOLC;  P0A879, TRPB_ECOLI;  
B7N474, TRPB_ECOLU;  B6I9X5, TRPB_ECOSE;  B1LH31, TRPB_ECOSM;  
Q1RCA6, TRPB_ECOUT;  C5BDB7, TRPB_EDWI9;  B2KCI5, TRPB_ELUMP;  
A4WB02, TRPB_ENT38;  B2VKT2, TRPB_ERWT9;  B7LS19, TRPB_ESCF3;  
B1YLS4, TRPB_EXIS2;  A7HMG8, TRPB_FERNB;  B0TWI3, TRPB_FRAP2;  
Q14FN2, TRPB_FRAT1;  A7N9D2, TRPB_FRATF;  Q2A5V3, TRPB_FRATH;  
B2SEK7, TRPB_FRATM;  A0Q8M6, TRPB_FRATN;  Q0BP45, TRPB_FRATO;  
Q5NE79, TRPB_FRATT;  A4IVS4, TRPB_FRATW;  Q8RGH8, TRPB_FUSNN;  
P19868, TRPB_GEOSE;  A4IQ82, TRPB_GEOTN;  Q7NGX9, TRPB_GLOVI;  
Q4QKF5, TRPB_HAEI8;  A5UC40, TRPB_HAEIE;  A5UEU5, TRPB_HAEIG;  
P43760, TRPB_HAEIN;  B0R332, TRPB_HALS3;  Q9HSC0, TRPB_HALSA;  
P18285, TRPB_HALVD;  Q7VGA7, TRPB_HELHP;  Q9ZJU9, TRPB_HELPJ;  
P56142, TRPB_HELPY;  B0UU34, TRPB_HISS2;  Q28LA6, TRPB_JANSC;  
P14552, TRPB_KLEAE;  B5XT02, TRPB_KLEP3;  A6T7W6, TRPB_KLEP7;  
Q1ISI9, TRPB_KORVE;  P17167, TRPB_LACCA;  B3W6W6, TRPB_LACCB;  
Q01998, TRPB_LACLA;  A2RK24, TRPB_LACLM;  Q02YB7, TRPB_LACLS;  
Q03CY3, TRPB_LACP3;  Q88WI0, TRPB_LACPL;  Q5X5Q2, TRPB_LEGPA;  
A5IBF7, TRPB_LEGPC;  Q5ZVY4, TRPB_LEGPH;  Q5WX32, TRPB_LEGPL;  
Q6AF67, TRPB_LEIXX;  B0SDM8, TRPB_LEPBA;  Q04U63, TRPB_LEPBJ;  
Q053M6, TRPB_LEPBL;  B0SM57, TRPB_LEPBP;  B1XY48, TRPB_LEPCP;  
Q72U05, TRPB_LEPIC;  Q8F149, TRPB_LEPIN;  Q92B81, TRPB_LISIN;  
C1KVS5, TRPB_LISMC;  Q71Z40, TRPB_LISMF;  B8DHB4, TRPB_LISMH;  
Q8Y6Q6, TRPB_LISMO;  A0AJ80, TRPB_LISW6;  Q65TF0, TRPB_MANSM;  
A6UW25, TRPB_META3;  B7L1H4, TRPB_METC4;  Q604P3, TRPB_METCA;  
Q1H0M1, TRPB_METFK;  Q60179, TRPB_METJA;  Q8TX91, TRPB_METKA;  
A2STA4, TRPB_METLZ;  B8I9V8, TRPB_METNO;  B1ZG57, TRPB_METPB;  
A2SHS4, TRPB_METPP;  B1LSI6, TRPB_METRJ;  B0UIA8, TRPB_METS4;  
P14638, TRPB_METVO;  P66985, TRPB_MYCBO;  O68905, TRPB_MYCIT;  
Q9CC54, TRPB_MYCLE;  P9WFX8, TRPB_MYCTO;  P9WFX9, TRPB_MYCTU;  
Q5F9W3, TRPB_NEIG1;  B4RJV8, TRPB_NEIG2;  Q84GJ9, TRPB_NEIGO;  
A9M354, TRPB_NEIM0;  Q9JVC0, TRPB_NEIMA;  Q9K0B5, TRPB_NEIMB;  
A1KSW2, TRPB_NEIMF;  Q0AGX5, TRPB_NITEC;  Q82WI2, TRPB_NITEU;  
Q2Y7R4, TRPB_NITMU;  Q2G8S7, TRPB_NOVAD;  Q8ESU4, TRPB_OCEIH;  
A6L9K4, TRPB_PARD8;  A1B8L3, TRPB_PARDP;  A7HPD3, TRPB_PARL1;  
Q7TTS6, TRPB_PARMW;  P54203, TRPB_PASMU;  Q6D4U0, TRPB_PECAS;  
C6DGZ5, TRPB_PECCP;  B4RCL0, TRPB_PHEZH;  Q7N486, TRPB_PHOLL;  
Q6LPA4, TRPB_PHOPR;  A6L7M5, TRPB_PHOV8;  Q6L271, TRPB_PICTO;  
A1VRR7, TRPB_POLNA;  Q126M1, TRPB_POLSJ;  A3PAN2, TRPB_PROM0;  
A2BZZ2, TRPB_PROM1;  A8G2H0, TRPB_PROM2;  A9BD24, TRPB_PROM4;  
A2BUE1, TRPB_PROM5;  Q31D17, TRPB_PROM9;  Q7VE26, TRPB_PROMA;  
B4EWH7, TRPB_PROMH;  Q7TUL2, TRPB_PROMM;  Q7TUH0, TRPB_PROMP;  
A2BNV9, TRPB_PROMS;  Q46HK9, TRPB_PROMT;  Q48QG6, TRPB_PSE14;  
Q15RZ5, TRPB_PSEA6;  P07345, TRPB_PSEAE;  Q1IH20, TRPB_PSEE4;  
Q4KKP4, TRPB_PSEF5;  A8F8F7, TRPB_PSELT;  A5VWL3, TRPB_PSEP1;  
Q3KK59, TRPB_PSEPF;  B0KFW3, TRPB_PSEPG;  Q88RP6, TRPB_PSEPK;  
P11080, TRPB_PSEPU;  B1J4B1, TRPB_PSEPW;  Q849P2, TRPB_PSESH;  
Q88B61, TRPB_PSESM;  P34817, TRPB_PSESY;  Q500R4, TRPB_PSEU2;  
A1STT0, TRPB_PSYIN;  Q8ZV44, TRPB_PYRAE;  A4WKQ9, TRPB_PYRAR;  
O59265, TRPB_PYRHO;  A1RVT1, TRPB_PYRIL;  Q8XXY0, TRPB_RALSO;  
B3PVV2, TRPB_RHIE6;  Q2KE82, TRPB_RHIEC;  Q1MND6, TRPB_RHIL3;  
Q98CN7, TRPB_RHILO;  B5ZV70, TRPB_RHILW;  Q92TC9, TRPB_RHIME;  
Q7UKG9, TRPB_RHOBA;  Q21XI6, TRPB_RHOFT;  Q2J2G4, TRPB_RHOP2;  
Q07UH1, TRPB_RHOP5;  Q6NDN6, TRPB_RHOPA;  Q21CB9, TRPB_RHOPB;  
Q13EQ2, TRPB_RHOPS;  B3Q605, TRPB_RHOPT;  Q161H9, TRPB_ROSDO;  
Q5LV94, TRPB_RUEPO;  Q1GK77, TRPB_RUEST;  A1AXS9, TRPB_RUTMC;  
B5F4M4, TRPB_SALA4;  A9MPY7, TRPB_SALAR;  Q57NT3, TRPB_SALCH;  
B5FU66, TRPB_SALDC;  B5R3P4, TRPB_SALEP;  B5R6M5, TRPB_SALG2;  
B4TJK8, TRPB_SALHS;  B4T6X1, TRPB_SALNS;  Q5PD17, TRPB_SALPA;  
A9MWR4, TRPB_SALPB;  C0Q3N4, TRPB_SALPC;  B5BIC1, TRPB_SALPK;  
B4TX38, TRPB_SALSV;  P0A2K2, TRPB_SALTI;  P0A2K1, TRPB_SALTY;  
A8GF82, TRPB_SERP5;  A1S7I2, TRPB_SHEAM;  A3D630, TRPB_SHEB5;  
A6WPX1, TRPB_SHEB8;  A9KTR7, TRPB_SHEB9;  Q12LE2, TRPB_SHEDO;  
Q084N8, TRPB_SHEFN;  B0TP63, TRPB_SHEHH;  A3QF73, TRPB_SHELP;  
Q8ECV0, TRPB_SHEON;  A8H2X4, TRPB_SHEPA;  A4Y845, TRPB_SHEPC;  
B8CLM6, TRPB_SHEPW;  A0KVD1, TRPB_SHESA;  Q0HK81, TRPB_SHESM;  
Q0HWI3, TRPB_SHESR;  A1RIE3, TRPB_SHESW;  B1KK02, TRPB_SHEWM;  
B2U0F2, TRPB_SHIB3;  Q31ZV4, TRPB_SHIBS;  Q32GS9, TRPB_SHIDS;  
Q0T5D5, TRPB_SHIF8;  P0A880, TRPB_SHIFL;  Q3Z109, TRPB_SHISS;  
C3MB99, TRPB_SINFN;  A6UEI1, TRPB_SINMW;  Q2NT52, TRPB_SODGM;  
A7X238, TRPB_STAA1;  A6U1J4, TRPB_STAA2;  Q2FH64, TRPB_STAA3;  
Q2FYR4, TRPB_STAA8;  A5ISQ4, TRPB_STAA9;  Q2YXX2, TRPB_STAAB;  
Q5HG47, TRPB_STAAC;  A6QGS4, TRPB_STAAE;  P66986, TRPB_STAAM;  
P66987, TRPB_STAAN;  Q6GH33, TRPB_STAAR;  Q6G9I7, TRPB_STAAS;  
A8Z244, TRPB_STAAT;  Q8NWU2, TRPB_STAAW;  Q5HPH0, TRPB_STAEQ;  
Q8CPB1, TRPB_STAES;  Q49XH8, TRPB_STAS1;  Q82A82, TRPB_STRAW;  
O05625, TRPB_STRCO;  B1W0P0, TRPB_STRGG;  B4SQU8, TRPB_STRM5;  
B2FNZ1, TRPB_STRMK;  Q8DVF3, TRPB_STRMU;  Q04IY9, TRPB_STRP2;  
B5E7M3, TRPB_STRP4;  C1C966, TRPB_STRP7;  B1I7S7, TRPB_STRPI;  
B8ZN59, TRPB_STRPJ;  Q97P32, TRPB_STRPN;  B2ISS1, TRPB_STRPS;  
Q8DNM8, TRPB_STRR6;  Q5LYI7, TRPB_STRT1;  Q5M350, TRPB_STRT2;  
Q03JC1, TRPB_STRTD;  C1CG42, TRPB_STRZJ;  C1CMD3, TRPB_STRZP;  
C1CT51, TRPB_STRZT;  B2V8W5, TRPB_SULSY;  Q2JLD7, TRPB_SYNJB;  
A5GP60, TRPB_SYNPW;  Q0I6V1, TRPB_SYNS3;  Q3AW11, TRPB_SYNS9;  
Q3AGY2, TRPB_SYNSC;  Q59992, TRPB_SYNY3;  B7IHA8, TRPB_THEAB;  
Q9HKD2, TRPB_THEAC;  C5A1P4, TRPB_THEGJ;  B6YSU5, TRPB_THEON;  
B0K8T6, TRPB_THEP3;  B0K2T9, TRPB_THEPX;  P16609, TRPB_THET2;  
Q5SJB9, TRPB_THET8;  Q8DG49, TRPB_THEVB;  Q97A51, TRPB_THEVO;  
Q3SHL9, TRPB_THIDA;  C4LC89, TRPB_TOLAT;  Q118P8, TRPB_TRIEI;  
Q3MBV3, TRPB_TRIV2;  A1WSF1, TRPB_VEREI;  A5CVH4, TRPB_VESOH;  
B7VGU7, TRPB_VIBA3;  A5F208, TRPB_VIBC3;  A7MRY0, TRPB_VIBCB;  
Q9KST6, TRPB_VIBCH;  C3LLL6, TRPB_VIBCM;  Q9RCE8, TRPB_VIBME;  
Q8D8B2, TRPB_VIBVU;  Q7MM56, TRPB_VIBVY;  Q8PJ28, TRPB_XANAC;  
Q3BRL3, TRPB_XANC5;  Q4UWD2, TRPB_XANC8;  B0RR84, TRPB_XANCB;  
Q8P7R8, TRPB_XANCP;  Q2P0U2, TRPB_XANOM;  B2SVN7, TRPB_XANOP;  
B2I9J2, TRPB_XYLF2;  Q9PDK4, TRPB_XYLFA;  B0U6K6, TRPB_XYLFM;  
Q87DR9, TRPB_XYLFT;  A1JPX6, TRPB_YERE8;  A7FI33, TRPB_YERP3;  
Q1C7P2, TRPB_YERPA;  B2K3W2, TRPB_YERPB;  Q8ZEG9, TRPB_YERPE;  
Q1CJ28, TRPB_YERPN;  A4TJ67, TRPB_YERPP;  Q66AK4, TRPB_YERPS;  
B1JKS2, TRPB_YERPY;  A8NEP3, TRP_COPC7;  P16578, TRP_COPCI;  
P13228, TRP_NEUCR;  O13831, TRP_SCHPO;  P00931, TRP_YEAST;  

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