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ENZYME

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ENZYME entry: EC 4.1.3.36

Accepted Name
1,4-dihydroxy-2-naphthoyl-CoA synthase
Alternative Name(s)
DHNA synthetase
dihydroxynaphthoic acid synthetase
naphthoate synthase
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing)
Reaction catalysed
2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
Comment(s)
  • This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments.
  • The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.
Cross-references
BRENDA4.1.3.36
EC2PDB4.1.3.36
ExplorEnz4.1.3.36
PRIAM enzyme-specific profiles4.1.3.36
KEGG Ligand Database for Enzyme Nomenclature4.1.3.36
IUBMB Enzyme Nomenclature4.1.3.36
IntEnz4.1.3.36
MEDLINEFind literature relating to 4.1.3.36
MetaCyc4.1.3.36
Rhea expert-curated reactions4.1.3.36
UniProtKB/Swiss-Prot
Q8GYN9, MENB_ARATHP23966, MENB_BACSUQ9TM10, MENB_CYACA
P0ABU1, MENB_ECOL6P0ABU0, MENB_ECOLIP44960, MENB_HAEIN
A0QRD3, MENB_MYCS2P9WNP4, MENB_MYCTOP9WNP5, MENB_MYCTU
Q9CLV5, MENB_PASMUQ7CQ56, MENB_SALTYQ5HH38, MENB_STAAC
Q99V48, MENB_STAAMQ7A6A9, MENB_STAANQ6GI37, MENB_STAAR
Q6GAG7, MENB_STAASQ8NXA0, MENB_STAAWQ5HQC3, MENB_STAEQ
Q8CPQ4, MENB_STAESQ4L549, MENB_STAHJQ49WG8, MENB_STAS1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
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