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ENZYME entry: EC 4.1.3.36

Accepted Name
1,4-dihydroxy-2-naphthoyl-CoA synthase.
Alternative Name(s)
DHNA synthetase.
Dihydroxynaphthoic acid synthetase.
Naphthoate synthase.
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing).
Reaction catalysed
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA <=> 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O
Comment(s)
  • This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments.
  • The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.
Cross-references
PROSITEPDOC00150
BRENDA4.1.3.36
EC2PDB4.1.3.36
ExplorEnz4.1.3.36
PRIAM enzyme-specific profiles4.1.3.36
KEGG Ligand Database for Enzyme Nomenclature4.1.3.36
IUBMB Enzyme Nomenclature4.1.3.36
IntEnz4.1.3.36
MEDLINEFind literature relating to 4.1.3.36
MetaCyc4.1.3.36
UniProtKB/Swiss-Prot
Q8GYN9, MENB_ARATH;  P23966, MENB_BACSU;  Q9TM10, MENB_CYACA;  
P0ABU1, MENB_ECOL6;  P0ABU0, MENB_ECOLI;  P44960, MENB_HAEIN;  
A0QRD3, MENB_MYCS2;  P9WNP4, MENB_MYCTO;  P9WNP5, MENB_MYCTU;  
Q9CLV5, MENB_PASMU;  Q7CQ56, MENB_SALTY;  Q5HH38, MENB_STAAC;  
Q99V48, MENB_STAAM;  Q7A6A9, MENB_STAAN;  Q6GI37, MENB_STAAR;  
Q6GAG7, MENB_STAAS;  Q8NXA0, MENB_STAAW;  Q5HQC3, MENB_STAEQ;  
Q8CPQ4, MENB_STAES;  Q4L549, MENB_STAHJ;  Q49WG8, MENB_STAS1;  

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