A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.3.36
Accepted Name |
1,4-dihydroxy-2-naphthoyl-CoA synthase.
|
Alternative Name(s) |
DHNA synthetase. |
Dihydroxynaphthoic acid synthetase. |
Naphthoate synthase. |
o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing). |
Reaction catalysed |
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA <=> 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O |
Comment(s) |
- This enzyme is involved in the synthesis of 1,4-dihydroxy-2-
naphthoate, a branch point metabolite leading to the biosynthesis of
menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1)
in plants), and many plant pigments.
- The coenzyme A group is subsequently removed from the product by
EC 3.1.2.28.
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Cross-references |
PROSITE | PDOC00150 |
BRENDA | 4.1.3.36 |
EC2PDB | 4.1.3.36 |
ExplorEnz | 4.1.3.36 |
PRIAM enzyme-specific profiles | 4.1.3.36 |
KEGG Ligand Database for Enzyme Nomenclature | 4.1.3.36 |
IUBMB Enzyme Nomenclature | 4.1.3.36 |
IntEnz | 4.1.3.36 |
MEDLINE | Find literature relating to 4.1.3.36 |
MetaCyc | 4.1.3.36 |
UniProtKB/Swiss-Prot |
Q8GYN9, MENB_ARATH; | P23966, MENB_BACSU; | Q9TM10, MENB_CYACA; |
P0ABU1, MENB_ECOL6; | P0ABU0, MENB_ECOLI; | P44960, MENB_HAEIN; |
A0QRD3, MENB_MYCS2; | P9WNP4, MENB_MYCTO; | P9WNP5, MENB_MYCTU; |
Q9CLV5, MENB_PASMU; | Q7CQ56, MENB_SALTY; | Q5HH38, MENB_STAAC; |
Q99V48, MENB_STAAM; | Q7A6A9, MENB_STAAN; | Q6GI37, MENB_STAAR; |
Q6GAG7, MENB_STAAS; | Q8NXA0, MENB_STAAW; | Q5HQC3, MENB_STAEQ; |
Q8CPQ4, MENB_STAES; | Q4L549, MENB_STAHJ; | Q49WG8, MENB_STAS1; |
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UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
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