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ENZYME entry: EC 4.1.99.2

Accepted Name
tyrosine phenol-lyase.
Alternative Name(s)
beta-tyrosinase.
Reaction catalysed
H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate
Comment(s)
  • The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • The enzyme also slowly catalyzes similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
Cross-references
BRENDA4.1.99.2
EC2PDB4.1.99.2
ExplorEnz4.1.99.2
PRIAM enzyme-specific profiles4.1.99.2
KEGG Ligand Database for Enzyme Nomenclature4.1.99.2
IUBMB Enzyme Nomenclature4.1.99.2
IntEnz4.1.99.2
MEDLINEFind literature relating to 4.1.99.2
MetaCyc4.1.99.2
Rhea expert-curated reactions4.1.99.2
UniProtKB/Swiss-Prot
P31013, TPL_CITFR;  P31012, TPL_CITIN;  Q897C2, TPL_CLOTE;  
P31011, TPL_ENTAG;  Q8RHM6, TPL_FUSNN;  E6SFG5, TPL_INTC7;  
D9R201, TPL_LACSW;  B2J908, TPL_NOSP7;  Q9CMK9, TPL_PASMU;  
O08501, TPL_SYMS1;  Q08897, TPL_SYMTH;  

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