ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.2.1.111

Accepted Name
1,5-anhydro-D-fructose dehydratase.
Alternative Name(s)
1,5-anhydro-D-arabino-hex-2-ulose dehydratase.
1,5-anhydro-D-fructose 4-dehydratase.
1,5-anhydro-D-fructose hydrolyase.
AF dehydratase.
AFDH.
Reaction catalysed
1,5-anhydro-D-fructose <=> 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H(2)O
Cofactor(s)
Ca(2+) or Na(+) or Mg(2+).
Comment(s)
Catalyzes one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D- fructose. The other enzymes involved in this pathway are EC 4.2.1.110, EC 4.2.2.13 and EC 5.3.2.7. Unlike EC 4.2.1.110 the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity toward aldose-2-uloses such as 2-dehydroglucose; in addition, it is inhibited by its end-product ascopyrone M and it cannot convert the end-product ascopyrone M into microthecin, as can EC 4.2.1.110.
Cross-references
BRENDA	4.2.1.111
EC2PDB	4.2.1.111
ExplorEnz	4.2.1.111
PRIAM enzyme-specific profiles	4.2.1.111
KEGG Ligand Database for Enzyme Nomenclature	4.2.1.111
IUBMB Enzyme Nomenclature	4.2.1.111
IntEnz	4.2.1.111
MEDLINE	Find literature relating to 4.2.1.111
MetaCyc	4.2.1.111