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ENZYME entry: EC 4.2.1.111

Accepted Name
1,5-anhydro-D-fructose dehydratase.
Alternative Name(s)
1,5-anhydro-D-arabino-hex-2-ulose dehydratase.
1,5-anhydro-D-fructose 4-dehydratase.
1,5-anhydro-D-fructose hydrolyase.
AF dehydratase.
AFDH.
Reaction catalysed
1,5-anhydro-D-fructose <=> ascopyrone M + H2O
Comment(s)
  • Catalyzes one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D- fructose.
  • The other enzymes involved in this pathway are EC 4.2.1.110, EC 4.2.2.13 and EC 5.3.2.7.
  • Unlike EC 4.2.1.110 the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity toward aldose-2-uloses such as 2-dehydroglucose; in addition, it is inhibited by its end-product ascopyrone M and it cannot convert the end-product ascopyrone M into microthecin, as can EC 4.2.1.110.
Cross-references
BRENDA4.2.1.111
EC2PDB4.2.1.111
ExplorEnz4.2.1.111
PRIAM enzyme-specific profiles4.2.1.111
KEGG Ligand Database for Enzyme Nomenclature4.2.1.111
IUBMB Enzyme Nomenclature4.2.1.111
IntEnz4.2.1.111
MEDLINEFind literature relating to 4.2.1.111
MetaCyc4.2.1.111
Rhea expert-curated reactions4.2.1.111

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-