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ENZYME

ENZYME entry: EC 4.2.1.121

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.121
Accepted Name
colneleate synthase
Alternative Name(s)
9-DES
9-divinyl ether synthase
CYP74D
CYP74D1
Reaction catalysed
(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O
Comment(s)
  • It catalyzes the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid.
  • It forms also (8E)-9-[(1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy]non-8-enoic acid (i.e. colnelenate) from (9Z,10E,12Z,15Z)-9-hydroperoxy-10,12,15- octadecatrienoate.
  • The corresponding 13-hydroperoxides are poor substrates.
  • The divinyl ethers colneleate and colnelenate have antimicrobial activity.
Cross-references
BRENDA4.2.1.121
EC2PDB4.2.1.121
ExplorEnz4.2.1.121
KEGG Ligand Database for Enzyme Nomenclature4.2.1.121
IUBMB Enzyme Nomenclature4.2.1.121
MEDLINEFind literature relating to 4.2.1.121
MetaCyc4.2.1.121
Rhea expert-curated reactions4.2.1.121
UniProtKB/Swiss-Prot
Q2WE96, CP74_ALLSAQ0PHS9, DES_CAPANQ9FPM6, DES_SOLLC
Q9AVQ1, DES_SOLTUQ8W2N5, DES_TOBAC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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