ENZYME entry: EC 4.2.1.121
| Accepted Name |
|---|
| Colneleate synthase.
|
| Alternative Name(s) |
|---|
| 9-DES. |
| 9-divinyl ether synthase. |
| CYP74D. |
| CYP74D1. |
| Reaction catalysed |
|---|
| (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate <=> (8E)-9-((1E,3Z)-nona-1,3-dien-1-yloxy)non-8-enoate + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- It catalyzes the selective removal of pro-R hydrogen at C-8 in the
biosynthesis of colneleic acid.
- It forms also (8E)-9-((1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy)non-8-enoic
acid (i.e. colnelenate) from (9Z,10E,12Z,15Z)-9-hydroperoxy-10,12,15-
octadecatrienoate.
- The corresponding 13-hydroperoxides are poor substrates.
- The divinyl ethers colneleate and colnelenate have antimicrobial
activity.
|
| Cross-references |
|---|
| BRENDA | 4.2.1.121 |
| EC2PDB | 4.2.1.121 |
| ExplorEnz | 4.2.1.121 |
| PRIAM enzyme-specific profiles | 4.2.1.121 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.121 |
| IUBMB Enzyme Nomenclature | 4.2.1.121 |
| IntEnz | 4.2.1.121 |
| MEDLINE | Find literature relating to 4.2.1.121 |
| MetaCyc | 4.2.1.121 |
| UniProtKB/Swiss-Prot |
|
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