Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.2.1.121

Accepted Name
Colneleate synthase.
Alternative Name(s)
9-DES.
9-divinyl ether synthase.
CYP74D.
CYP74D1.
Reaction catalysed
(9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate <=> (8E)-9-((1E,3Z)-nona-1,3-dien-1-yloxy)non-8-enoate + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • It catalyzes the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid.
  • It forms also (8E)-9-((1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy)non-8-enoic acid (i.e. colnelenate) from (9Z,10E,12Z,15Z)-9-hydroperoxy-10,12,15- octadecatrienoate.
  • The corresponding 13-hydroperoxides are poor substrates.
  • The divinyl ethers colneleate and colnelenate have antimicrobial activity.
Cross-references
BRENDA4.2.1.121
EC2PDB4.2.1.121
ExplorEnz4.2.1.121
PRIAM enzyme-specific profiles4.2.1.121
KEGG Ligand Database for Enzyme Nomenclature4.2.1.121
IUBMB Enzyme Nomenclature4.2.1.121
IntEnz4.2.1.121
MEDLINEFind literature relating to 4.2.1.121
MetaCyc4.2.1.121
UniProtKB/Swiss-Prot
Q0PHS9, DES_CAPAN;  Q9FPM6, DES_SOLLC;  Q9AVQ1, DES_SOLTU;  
Q8W2N5, DES_TOBAC;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-