A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2-(omega-methylthio)alkylmalate dehydratase.
Reaction catalysed
  • A 2-(omega-methylthio)alkylmalate <=> a 2-(omega-methylthio)alkylmaleate + H(2)O
  • A 3-(omega-methylthio)alkylmalate <=> a 2-(omega-methylthio)alkylmaleate + H(2)O
  • The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates.
  • By catalyzing a dehydration of a 2-(omega-methylthio)alkylmaleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates.
  • The enzyme is a heterodimer comprising a large and a small subunits.
  • The large subunit can also bind to an alternative small subunit, forming EC, which participates in L-leucine biosynthesis.
PRIAM enzyme-specific profiles4.2.1.170
KEGG Ligand Database for Enzyme Nomenclature4.2.1.170
IUBMB Enzyme Nomenclature4.2.1.170
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-