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ENZYME entry: EC 4.2.1.170

Accepted Name
2-(omega-methylthio)alkylmalate dehydratase.
Reaction catalysed
  • A 2-(omega-methylthio)alkylmalate <=> a 2-(omega-methylthio)alkylmaleate + H(2)O
  • A 3-(omega-methylthio)alkylmalate <=> a 2-(omega-methylthio)alkylmaleate + H(2)O
Comment(s)
  • The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates.
  • By catalyzing a dehydration of a 2-(omega- methylsulfanyl)alkylmaleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates.
  • The enzyme is a heterodimer comprising a large and a small subunits.
  • The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, which participates in L-leucine biosynthesis.
Cross-references
BRENDA4.2.1.170
EC2PDB4.2.1.170
ExplorEnz4.2.1.170
PRIAM enzyme-specific profiles4.2.1.170
KEGG Ligand Database for Enzyme Nomenclature4.2.1.170
IUBMB Enzyme Nomenclature4.2.1.170
IntEnz4.2.1.170
MEDLINEFind literature relating to 4.2.1.170
MetaCyc4.2.1.170
Rhea expert-curated reactions4.2.1.170
UniProtKB/Swiss-Prot
Q94AR8, LEUC_ARATH;  Q9ZW84, LEUD1_ARATH;  Q9LYT7, LEUD2_ARATH;  

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