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ENZYME entry: EC 4.2.1.79

Accepted Name
2-methylcitrate dehydratase.
Alternative Name(s)
2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase.
2-methylcitrate hydro-lyase.
Reaction catalysed
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate <=> (Z)-but-2-ene-1,2,3-tricarboxylate + H(2)O
Comment(s)
  • Specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)- methylcitrate.
  • Can also use cis-aconitate as a substrate but more slowly.
  • Both this enzyme and EC 4.2.1.3 are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate.
Cross-references
BRENDA4.2.1.79
EC2PDB4.2.1.79
ExplorEnz4.2.1.79
PRIAM enzyme-specific profiles4.2.1.79
KEGG Ligand Database for Enzyme Nomenclature4.2.1.79
IUBMB Enzyme Nomenclature4.2.1.79
IntEnz4.2.1.79
MEDLINEFind literature relating to 4.2.1.79
MetaCyc4.2.1.79
UniProtKB/Swiss-Prot
Q8NSH9, PRPD1_CORGL;  Q8NSL3, PRPD2_CORGL;  Q937N6, PRPD_CUPNE;  
Q54IJ0, PRPD_DICDI;  Q8X693, PRPD_ECO57;  P77243, PRPD_ECOLI;  
H8F0D6, PRPD_MYCTE;  O06582, PRPD_MYCTU;  Q8Z903, PRPD_SALTI;  
P74840, PRPD_SALTY;  Q6C354, PRPD_YARLI;  Q12428, PRPD_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-