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ENZYME

ENZYME entry: EC 4.2.1.79

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.79
Accepted Name
2-methylcitrate dehydratase
Alternative Name(s)
2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase
2-methylcitrate hydro-lyase
Reaction catalysed
(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O
Comment(s)
  • Specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)- methylcitrate.
  • Can also use cis-aconitate as a substrate but more slowly.
  • Both this enzyme and EC 4.2.1.3 are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate.
Cross-references
BRENDA4.2.1.79
EC2PDB4.2.1.79
ExplorEnz4.2.1.79
KEGG Ligand Database for Enzyme Nomenclature4.2.1.79
IUBMB Enzyme Nomenclature4.2.1.79
MEDLINEFind literature relating to 4.2.1.79
MetaCyc4.2.1.79
Rhea expert-curated reactions4.2.1.79
UniProtKB/Swiss-Prot
Q8NSH9, PRPD1_CORGLQ8NSL3, PRPD2_CORGLQ937N6, PRPD_CUPNE
Q54IJ0, PRPD_DICDIQ8X693, PRPD_ECO57P77243, PRPD_ECOLI
H8F0D6, PRPD_MYCTEO06582, PRPD_MYCTUQ8Z903, PRPD_SALTI
P74840, PRPD_SALTYQ6C354, PRPD_YARLIQ12428, PRPD_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-