A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.2.1.80

Accepted Name
2-oxopent-4-enoate hydratase.
Alternative Name(s)
2-keto-4-pentenoate hydratase.
OEH.
Reaction catalysed
(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(2)O
Comment(s)
  • The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds.
  • Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer.
  • The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate.
  • However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate.
  • In some organisms the enzyme forms a complex with EC 4.1.1.77.
Cross-references
BRENDA4.2.1.80
EC2PDB4.2.1.80
ExplorEnz4.2.1.80
PRIAM enzyme-specific profiles4.2.1.80
KEGG Ligand Database for Enzyme Nomenclature4.2.1.80
IUBMB Enzyme Nomenclature4.2.1.80
IntEnz4.2.1.80
MEDLINEFind literature relating to 4.2.1.80
MetaCyc4.2.1.80
UniProtKB/Swiss-Prot
Q9KWS4, AMNF_PSESP;  Q47HM0, MHPD1_DECAR;  Q400K2, MHPD1_PSEPU;  
Q47GC8, MHPD2_DECAR;  Q49KF9, MHPD2_PSEPU;  Q706S1, MHPD3_PSEPU;  
C1DRI8, MHPD_AZOVD;  A4JPX9, MHPD_BURVG;  Q9S156, MHPD_COMTE;  
A7ZI97, MHPD_ECO24;  B7L506, MHPD_ECO55;  Q8XEC1, MHPD_ECO57;  
B5Z2Q5, MHPD_ECO5E;  B7NK05, MHPD_ECO7I;  B7MPB7, MHPD_ECO81;  
B7M2Z8, MHPD_ECO8A;  A7ZWZ7, MHPD_ECOHS;  P77608, MHPD_ECOLI;  
B7N8Q7, MHPD_ECOLU;  B1LIN5, MHPD_ECOSM;  A6TAC6, MHPD_KLEP7;  
B2JQV8, MHPD_PARP8;  Q13VU0, MHPD_PARXL;  Q3Z556, MHPD_SHISS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-